An antiseptic composition suitable for use on skin and wounds comprising a source of an antimicrobial agent and an agent which disrupts biofilms. More, particularly the invention relates to a composition capable of providing effective antimicrobial activity while at the same time avoiding wound and skin irritation and retardation of wound healing.

A wound dressing system that includes a conformal cover and an infusion pump is provided. The cover includes a fluid port and an oxygen catalyst. The infusion pump is configured to deliver a bioactive liquid to the cover via the fluid port. The liquid includes an oxygen precursor. Upon combination, the oxygen catalyst and precursor react to form oxygen. A method of applying a wound dressing system including a bioactive powder, a bioactive liquid, and a conformal cover to a wound site is also provided. The method includes applying the powder to the wound site; securing the cover around the wound site, where the cover includes an oxygen catalyst and a fluid port; and delivering the bioactive liquid to at least an inner layer of the cover via the fluid port, where the bioactive liquid includes an oxygen precursor.

An embodiment includes a wound dressing comprising: a shape memory polymer (SMP) foam, including open cells, having first and second states; and a hydrogel (HG) included within the cells; wherein (a) in a first position a composite, including the SMP foam and the HG, is configured to be located proximate a hemorrhagic tissue with the SMP foam in the first state; (b) in a second position the composite is configured to be expanded to the second state against the hemorrhagic tissue when the SMP foam is plasticized at 37 C. depressing a glass transition temperature (T.sub.g) of the SMP foam to below 25 C. Other embodiments are described herein.

The invention provides an antimicrobial wound dressing comprising a wound dressing substrate comprising at least one species of Formula (I), wherein X is a halogen, and wherein the species is complexed with a non-polymeric counterion and/or complexed with the wound dressing substrate.

[IIX].sup.Formula (I)

Methods and compositions for treating various indications by lessening oxidative stress in a patient are provided. A pharmaceutical composition comprises between about 0.001% to about 10.0%, or more specifically between about 0.015% to about 5%, sodium iodide or catalase by weight. The iodine ion or the catalase dissociates hydrogen peroxide into water and molecular oxygen to interrupt biological events that result in negative side effects. The pharmaceutical composition further comprises in some cases a reducing agent or various carrier materials. The pharmaceutical composition is in some cases formulated for a variety of delivery methods.

Adhesive wound dressing that comprises an absorbent matrix (A) adhering to the central portion of a polyurethane backing (B) having an adhesive layer for the skin, said matrix (A) comprising: a. a breathable and porous polyethylene film at the end designed to come into contact with the wound; b. an absorbent layer made of non-woven fabric adjacent to film a), said absorbent layer consisting of: i. 60-65% viscose ii. 25-30% polyester iii. 5-15% polypropylene; c. a layer of polyethylene inserted between layer b) and a layer d. of hydrophobic polystyrene, the latter being in contact with the central portion of polyurethane backing (B); wherein matrix (A) is impregnated with a solution of one or more polysaccharides or the salts thereof.

Compositions comprising starch-acrylic polymers combined with elemental iodine are disclosed. The SAP-I compositions release non-toxic amounts of iodophor iodine in a sustained, controlled manner. Methods of formation and use of the compositions along with methods of creation and use of devices incorporating the compositions in a variety of healthcare and non-healthcare settings are set forth in detail herein.

A catheter system for draining a fluid from a bladder. The system includes a catheter combined with an amount of chlorine dioxide adapted to reduce infection in catheter associate urinary tract infections. The chlorine dioxide is adapted for use with at least one of a hydrophilic coating on an outer surface of the catheter, a wetting fluid that interacts with the hydrophilic coating and a lubricant in contact with the outer surface of the catheter.

The present disclosure relates generally to materials and medical devices impregnated with antimicrobial compounds. More specifically, the materials are medical matrix materials comprising nanopores or nanochannels in which the antimicrobial compounds are disposed. In other embodiments, medical matrix materials comprises nanomaterials and antimicrobials distributed throughout the material. The materials described herein are useful for a broad spectrum of medical devices and consumer products. The present disclosure further provides methods of making the antimicrobial materials and medical devices disclosed herein.

The invention provides a reusable urinary catheter kit comprising a container comprising: a urinary catheter; and a medium comprising at least one species independently chosen from: hypochlorous acid, at least one hypochlorite salt, chlorine dioxide, and combinations thereof. The invention further provides a method of sterilising and/or lubricating a reusable urinary catheter using at least one species independently chosen from: hypochlorous acid, at least one hypochlorite salt, chlorine dioxide, and combinations thereof.