The present invention relates to skin care additive which comprises a diester skin care additive which is the reaction product of a fatty alkoxylated ester and a straight, branched or aromatic polyol or poly acid, where the skin care additive provides improved wet lubricancy and/or reduced skin irritancy. More especially, there is provided a personal hygiene product treated with the skin care additive, as such the invention also relates to providing the care additive as a coating on a personal hygiene product. The present invention may also provide use of such a personal hygiene product comprising said skin care additive to prevent or alleviate dermatitis, and in particular nappy rash.

Magnesium-infused and menthol-infused kinesiology tape is disclosed. The tape comprises an absorbent fabric substrate with adhesive on one side of the substrate to be applied to a person's skin and includes magnesium salt and menthol for promoting pain relief while the tape adheres to the person's skin.

The invention relates to antimicrobial and/or antiviral fabric compositions comprising ascorbic acid, citric acid, sodium hypophosphite, or a mixture thereof. The ascorbic acid may be covalently attached to at least one cellulosic portion of the fabric composition. The invention also relates to methods for preparing such fabric compositions.

A drug-releasing polymer composition is disclosed. It may include a major component, which may be ethylene vinyl acetate, and may further include at least one or two release-modifying materials, and may further include at least one or two drugs. The release-modifying materials may be polyethylene glycol and polycaprolactone. The drugs may be minocycline and rifampin. There may be an interaction such that in the presence of two different release-modifying materials, drug release may be greater than with either release-modifying material alone. There may be an interaction such that in the presence of two drugs, drug release may be greater than with either drug alone, and antibacterial performance may be enhanced. Release durations as long as two months are possible. In addition, the composition can be provided on a medical device that is configured for implanting in body tissue for an extended time period.

The present invention relates to a medical device suitable for being inserted into the lumen of an anatomic structure of a subject, said medical device comprising means for administration of TRPC6 inhibitor, wherein said means comprises the TRPC6 inhibitor. The present invention further concerns a method of manufacturing a medical device suitable for being inserted into the lumen of an anatomic structure of a subject. Also, the invention relates to a TRPC6 inhibitor for use in the treatment or prevention of a disease associated with neointimal hyperplasia associated with the migration of smooth muscular cells. The invention also relates to a method of treating or preventing a disease associated with neointimal hyperplasia, said method comprising administering a TRPC6 inhibitor to a subject in need thereof. Also envisaged is a method of inhibiting migration of smooth muscle cells. The invention additionally relates to an in vitro test kit comprising: (a) small muscle cells (SMCs); (b) a surface suitable for SMC cultivation coated with a TRPC6 inhibitor. Also concerned is a pharmaceutical composition comprising a TRPC6 inhibitor and a pharmaceutically acceptable carrier.

The present invention relates to methods and compositions for rendering a surface resistant to bio-film formation by a combination of an antimicrobial agent, an organic hydroxy acid, lubricious biomedical polymer and solvent. The invention provides for compositions which may be used to render surfaces bio-film resistant, articles having bio-film resistant surfaces, and methods for their preparation. The present invention may be advantageously applied to medical articles as well as articles used in non-medical contexts, such as child care or food preparation.

Described here are systems and methods for delivering an active agent to target tissues of the ear, nose, or throat using an expandable member having drug crystals layered thereon, and methods for manufacturing such systems. The expandable member can be delivered to the target tissues in a low-profile configuration and expanded to contact and/or dilate surrounding tissue. Expansion of the expandable member transfers the drug crystals to the target tissues, which then act as an in situ depot that enables maintenance of a therapeutic level of an active agent for a desired time period after removal of the expandable member. Multiple expansions of a single expandable member can be employed during treatment. For example, the systems and methods can be useful when it is desired to treat multiple paranasal sinuses with a single expandable member.

The present disclosure provides a biomaterial and a method for promoting tissue regeneration by using the biomaterial.

The invention relates to a wound dressing or other wound contact medium containing an acetyl donor compound, and being free from peroxide compounds which is activatable by a means of applying hydrogen peroxide. The wound dressing or other wound contact medium is suitable for use in the prevention and/or treatment of wound infection in a patient comprising applying the wound dressing or other wound contact medium to a wound of the patient, and subjecting the wound dressing or other wound contact medium to a means of applying hydrogen peroxide so that the acetyl donor compound of the wound dressing or other wound contact medium is activated by the hydrogen peroxide to produce peracetic acid.

A method for the treatment of a local pigmentation disorder comprises applying to skin affected by the disorder a transdermal therapeutic system which comprises 4-n-butylresorcinol as an active ingredient.