The present invention relates to a gene delivery stent using titanium oxide thin film coating and a method for fabricating the gene delivery stent. The gene delivery stent according to the present invention may be loaded with a drug having anti-inflammatory and anti-thrombotic effects and simultaneously deliver a gene capable of inhibiting proliferation of vascular smooth muscle cells. Accordingly, late thrombosis and metal allergy may be reduced, and vascular restenosis in the stent region may be prevented, thereby making it possible to increase treatment effects of the bare metal stent.

This present invention concerns a new combination of balloon catheters and formulations containing active substances that adhere to the surface of the balloon membrane. Furthermore the present invention concerns coating processes for the manufacture of these balloon catheters as well as their use in the treatment and prophylaxis of vascular diseases.

Devices for preventing and/or otherwise inhibiting biofilm formation include a lumen and/or cavity coupled with a wall configured for holding oils, which leach through the wall of the device to the surface, the oil at the surface creating a smooth surface coating.

The present invention includes compositions and methods useful for removing microorganisms and/or biofilm-embedded microorganisms from the surface of a medical device or subject's body. The present invention further includes compositions and methods useful for coating medical devices. The present invention further includes compositions and methods useful for preventing or reducing the growth or proliferation of microorganisms and/or biofilm-embedded microorganisms on the surface of a medical device or subject's body.

A microneedle patch includes a substrate and a plurality of microneedles disposed on the substrate, each of the plurality of microneedles including: (i) one or more polymers dissolvable in human skin layer, (ii) a plurality of lipid nanoparticles, and (iii) a nucleic acid drug encapsulated by the plurality of lipid nanoparticles; each of the plurality of microneedles being defined with a tip end portion that enables dermal penetration, and the microneedle patch being adapted to be stored at room temperature.

The subject invention provides topical therapeutic compositions and methods of their use for enhanced healing of wounds, including burns, and scars of the skin. Specifically, in one embodiment, the subject invention provides materials and methods for reducing the healing time of skin wounds and for reducing the appearance of scars. The subject invention utilizes topical compositions comprising microbial growth by-products and, optionally, a topically-acceptable carrier. In specific embodiments, the microbial growth by-products are biosurfactants.

Fatty acid-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.

Provided is a malleable implant configured to fit at or near a bone defect site to promote bone growth, the malleable implant comprising: a biodegradable polymer, mineral particles, and an oxysterol, the implant configured to become moldable upon being wetted with a fluid. Methods of making and use are further provided.

The present invention relates to a lipiodol-based composite embolic agent of active metal microspheres or nano-hydrides, a preparation method therefor, and applications thereof. It belongs to the technical field of medicines. The composite embolic agent of the present invention is composed of lipiodol and active metal microspheres or nano-hydrides, wherein the lipiodol serves as a dispersant and a protectant that can decrease the reaction rate of the active metal microspheres or nano-hydrides with water. Methods for preparing the active metal microspheres and the nano-hydrides involved in the present invention are simple, and can be used for mass preparation in a short time. The composite embolic agent prepared in the present invention is locally delivered to liver tumor tissues by interventional operation to allow deposition of lipiodol on the liver tumor tissue to induce embolization; in addition, active metal microspheres or hydrides release hydrogen in situ to induce hydrogen treatment, thereby amplifying the embolization effect. The composite embolic agent as defined in the present invention regulates tumor microenvironment by in situ release of hydrogen, hydroxide, or the like from the active metal microspheres or hydrides, showing a better combined embolization effect than simple lipiodol embolization.

Methods for applying a sphingolipid aggregate coating to a surface of a substrate for inhibition and prevention of biofilm growth, methods for inhibiting and preventing biofilms, biofilm-inhibiting coatings and coated devices are provided. Coating processes include suspending an amount of sphingolipid in a medium-to-fast-evaporating organic solvent; b) applying energy to the suspension sufficient to create a colloidal dispersion of sphingolipid in the solvent; c) heating the dispersion sufficient to create a solution; and d) coating the surface of the substrate with at least one application of solution, each application followed directly by a complete solvent evaporation period. The resulting coatings exhibit aggregate architectures particularly effective for inhibition and prevention of biofilms.