The present invention provides compositions for extended release of one or more active ingredients, comprising a lipid-saturated matrix formed from a non-biodegradable polymer or a block-co-polymers comprising a non-biodegradable polymer and a biodegradable polymer. The present invention also provides methods of producing the matrix compositions and methods for using the matrix compositions to provide controlled release of an active ingredient in the body of a subject in need thereof.

[Objective]

To provide a pressure-sensitive adhesive agent for skin containing a pressure-sensitive adhesive agent for skin that has favorable shape retention properties and skin-follow up properties without being adversely affected by moisture from excrement or the like even when adhered to the skin over a long period of time and yet leaves no adhesive residue after separation and a pressure-sensitive adhesive sheet for skin contains a base material and a layer of the pressure-sensitive adhesive agent for skin.

[Means to Achieve Objectives]

A pressure-sensitive adhesive agent for skin contains 2 to 35% by weight of a thermoplastic elastomer, 25 to 60% by weight of a hydrophilic polymer compound, 16 to 40% by weight of a softener, and 0.01 to 4.8% by weight of a physiologically active agent; and has a water absorption 3 hours after of 55 to 240% and a water absorption 24 hours after of 240 to 450%. A pressure-sensitive adhesive sheet for skin contains a base material and a layer of a pressure-sensitive adhesive agent for skin that contains 2 to 35% by weight of a thermoplastic elastomer, 25 to 60% by weight of a hydrophilic polymer compound, 16 to 40% by weight of a softener, and 0.01 to 4.8% by weight of a physiologically active agent and is formed on one side of the base material; and has a water absorption 3 hours after of 55 to 240% and a water absorption 24 hours after of 240 to 450%.

The invention relates to a suture thread material comprising at least one polymer and at least one eutectic mixture. The polymer can be a biocompatible polymer such as polycaprolactone or PLGA. The eutectic mixture may comprise maleic acid and an antibiotic such as metronidazole. Other eutectic mixtures can be used in suture thread materials to reduce SSis and/or to decrease pain and/or to increase lubricity of sutures. The invention also provides a method for the production of sutures with drug loadings, the method comprising the use of therapeutic deep eutectic solvent (THEDES) technology to significantly increase drug content in suture matrices.

An antimicrobial surface treatment method comprising the step of contacting a stainless-steel surface with an aqueous dispersion of at least one functional-lipid construct where the lipid moiety is a phosphatidylethanolamine and the functional moiety confers the antimicrobial activity.

Described herein are therapeutic compositions comprising a rhamnolipid impregnated within an electrospun support, and methods of using the same. Exemplary therapeutic compositions may be used for wound treatment.

The present disclosure relates to methods and compositions for suppressing pathogenic bacterial growth, fungal growth, or microbial growth in or on a selected area of skin or open wound. An area of the skin or open wound having pathogenic bacterial growth, fungal growth, or microbial growth is selected for the suppression of the growth. A suppressing material comprising punicic acid is applied to the selected area of the skin and the pathogenic bacterial growth, fungal growth, or microbial growth is suppressed. Methods of making and using the suppressing material comprising punicic acid are also presently provided.

[Objective] To provide a pressure-sensitive adhesive agent for skin containing a pressure-sensitive adhesive agent for skin that has favorable shape retention properties and skin-follow up properties without being adversely affected by moisture from excrement or the like even when adhered to the skin over a long period of time and yet leaves no adhesive residue after separation and a pressure-sensitive adhesive sheet for skin contains a base material and a layer of the pressure-sensitive adhesive agent for skin. [Means to Achieve Objectives] A pressure-sensitive adhesive agent for skin contains 2 to 35% by weight of a thermoplastic elastomer, 25 to 60% by weight of a hydrophilic polymer compound, 16 to 40% by weight of a softener, and 0.01 to 4.8% by weight of a physiologically active agent; and has a water absorption 3 hours after of 55 to 240% and a water absorption 24 hours after of 240 to 450%. A pressure-sensitive adhesive sheet for skin contains a base material and a layer of a pressure-sensitive adhesive agent for skin that contains 2 to 35% by weight of a thermoplastic elastomer, 25 to 60% by weight of a hydrophilic polymer compound, 16 to 40% by weight of a softener, and 0.01 to 4.8% by weight of a physiologically active agent and is formed on one side of the base material; and has a water absorption 3 hours after of 55 to 240% and a water absorption 24 hours after of 240 to 450%.

Disclosed herein is the correlation of chemical properties of oils with the physical properties of a resulting cured oil composition. Also disclosed are biocompatible materials and coatings for medical devices prepared using enriched oils and methods for enhancing or modifying the physical and chemical characteristics of cured oils by enriching such oils with fatty acid alkyl esters. Methods of tailoring the properties of biocompatible materials and coatings to deliver one or more therapeutic agents are also provided.

The present disclosure relates to a medical device having irregular and/or curved silicone surfaces, wherein at least a part of the irregular and/or curved silicone surfaces is coated with rhamnolipids. The present disclosure also relates to a method of coating a medical device having irregular and/or curved silicone surfaces with rhamnolipids, wherein the method comprises the steps of 1) activating the silicone surfaces that are to be coated by introducing free amino-groups; and 2) covalently attaching rhamnolipids to said silicone surfaces. The present disclosure also relates to a voice prosthesis, for mounting in a fistula between trachea and esophagus, wherein at least a part of the voice prosthesis comprises silicone and at least a part of said silicone being coated with rhamnolipids.

The present invention relates to an adhesive for a stoma and an adhesive tape for a stoma comprising the same. Specifically, the present invention relates to: an adhesive for a stoma, which can be attached to an affected part, having high adhesion, and has improved functionality for easy detachment from the skin; and an adhesive tape for a stoma comprising the same.