The present disclosure is directed to a device for delivering an antimicrobial composition into an infusion device. The disclosure provides a method for preventing infection and microbial ingress in medical device connections. The device includes a male connector with a distal tip and a recess at the distal tip. The surface of the recess includes an antimicrobial composition. In certain implementations a male luer comprises a tapered sealing member further comprising a recess containing chlorhexidine acetate.

The present invention concerns a three-dimensional bipolymeric matrix deploying biological and biomechanical activity, able to neutralize the various physiopathological parameters involved in the development and worsening of skin lesions and/or sores, combining: a first polymeric network comprising first colloids (Col-1) bonded non-covalently to an unsulfated crosslinked polysaccharide; and a second polymeric network comprising second colloids (Col-2) bonded covalently or non-covalently to a sulfated polysaccharide.

A collagen scaffold for the delivery of bioactive agents such as antimicrobials comprising a first collagen matrix layer and a second collagen matrix layer in which the first collagen matrix layer comprises a first bioactive agent physically entrapped in the first collagen matrix layer and the second collagen matrix layer comprises a second bioactive agent chemically attached to the second collagen matrix layer for an initial high concentration elution of antimicrobial from the first collagen matrix layer followed by a sustained release from the second collagen matrix layer to prevent re-infection.

The present subject matter relates to a polyurethane composition comprising a polyurethane with at least one free acid group salted with a biguanide free base.

Technologies for fibers with nanotechnology is disclosed. In the illustrative embodiment, a preform is 3D printed with one or more sacrificial cores and one or more hollow channels. The preform is drawn into a fiber, and one or more metal core(s) is inserted into the hollow channel during the fiber draw. The fiber is then heated, breaking up the sacrificial cores into balls through capillary action. The fiber can be etched, exposing the balls made up of the sacrificial cores. The balls can be selectively etched, exposing the metal core(s) of the fiber. Additional embodiments are disclosed.

The invention provides novel compounds and polymers, degradable hydrogel compositions, medical devices and implants, as well as methods thereof, that allow on-demand release and controlled delivery of antimicrobial agents.

Disclosed herein is a composite material suitable for inhibiting biofilm growth, the composite material comprising a substrate material and a random copolymeric material covalently bonded to a surface of the substrate material. The random copolymer contains repeating units having at least one functional group bearing a cationic charge and repeating units having at least one functional group bearing an anionic charge, where the repeating units are derived from compatible monomers that belong to different monomer classes having differing polymerisation kinetics. Specifically, the random copolymeric material is poly(AMPTMA-ran-SPM), wherein AMPTMA is (3-acrylamidopropyl) trimethylammonium chloride and SPM is 3-sulfopropyl methacrylate potassium. Also disclosed are methods of manufacturing said material and applications thereof.

The present invention provides methods for the prevention, control, disruption and treatment of bacterial biofilms with lysin, particularly lysin having capability to kill Staphlococcal bacteria, including drug resistant Staphylococcus aureus, particularly the lysin PlySs2. The invention also provides compositions and methods for use in treatment or modulation of bacterial biofilm(s) and biofilm formation.

Durable, anti-fouling, crosslinked zwitterionic coatings that are grafted to the surface of a substrate through covalent bonding are disclosed. When exposed to a light source, zwitterionic monomers react with a crosslinker and with activated radicals at the surface of the substrate, simultaneously forming the crosslinked zwitterionic coating and anchoring it to the surface of the substrate. Photomasking techniques can be used to micropattern the zwitterionic coatings. The zwitterionic coatings can be applied to a variety of substrates, including medical devices and systems.

Systems and methods for biofilm inoculation including a feeding tube having a distal end for placement in the gut of a patient, and a biofilm coated or otherwise provided on the distal end of the feeding tube for introducing the biofilm to the gut of the patient. In example embodiments, the biofilm can be colostrum, breast milk or one or more probiotics.