Embodiments of the disclosure include methods and compositions related to repair of weakenings or openings in a tissue of an individual, including at least a muscular wall, for example. In specific cases, a mesh comprising phosphate crosslinked poly(vinyl alcohol) polymer (PVA-P) is utilized for such methods, including for hernia repair of any kind. In particular embodiments, one side of the mesh comprises decellularized gel matrix to provide for enhanced tissue healing.

Disclosed are a bifunctional peptide having the capability to reduce inflammation and the capability to facilitate differentiation of stem cells into chondrocytes and the use thereof. Advantageously, the bifunctional peptide is useful for the prevention or treatment of arthritis accompanied by inflammation and damage of cartilage tissue due to excellent effects of reducing inflammation and facilitating differentiation of stem cells into chondrocytes, can be easily applied to various surgical regenerative treatments including orthopedic treatments, and can shorten the treatment period.

Monomer(s) based on a 3,4-dihydro-2H-1,3-benzoxazine derivative. Alternatively, a composition comprising a mixture of the monomer(s) and of a second benzoxazine derivative selected from the group consisting of monofunctional amines bridged with diphenolic compounds, monophenolic compounds bridged with diamines and diamines bridged by diphenolic compounds, or a mixture thereof. These compounds are suited for the preparation of benzoxazine derivative heterogeneous polymers, for example having the shape of coatings or films, exhibiting enhanced anti-inflammatory and/or anti-oxidant properties. A material with a coated substrate with the heterogeneous polymer may be a part of implantable materials, such as implantable metallic apparatus such as a catheter, a metallic implant, or a metallic prosthesis, biologically compatible. These implantable materials may be safely used because they are preventing any inflammatory and/or oxidative reaction(s) from a host into which the coated substrate is grafted or implanted.

In an embodiment, a drug delivery system and method of use thereof to treat inflammation and bacterial pathogens including multi-drug resistant pathogens, such as MDR-Pseudomonas aeruginosa, or reactive oxygen species in a subject is provided. In some embodiments, the drug delivery system includes a polymeric material, an excepient, an antioxidant agent, and an anti-inflammatory and antimicrobial agent. In some embodiments, the anti-inflammatory and antimicrobial agent is a salt of an anti-inflammatory agent and an antimicrobial agent formulated to provide a combination of antimicrobial and anti-inflammatory action from a single molecule. In some embodiments, the combined anti-inflammatory and antimicrobial agent is a silver salt of ibuprofen. In other embodiments, the combined anti-inflammatory and antimicrobial agent is unmodified, native ibuprofen.

Drug delivery systems and wearable articles including the drug delivery systems are provided. The drug delivery systems may include a substrate coated with at least one polymer and at least one active compound. The substrate is operable to include yarns, yarn precursors, threads, filaments, fibers, and/or other suitable substrates. Methods for manufacturing drug delivery systems are also provided. The methods are operable to include disposing a solution including a monomer and an active compound on the substrate. The methods are also operable to include exposing the solution and the substrate to UV light to initiate polymerization of the solution.

Described herein is a multifunctional polymer-nanoparticle composition for use in wound care applications. Methods of manufacturing the described compositions are also disclosed herein.

Disclosed are nasal dressings and nasal stents comprising a collagen foam. Also disclosed are methods of making and using such nasal dressings and nasal stents. In an embodiment, a nasal dressing or nasal stent is formed by a method comprising the steps of: forming an aqueous mixture of from 5 to 25 wt % of acid-soluble collagen and from 75 to 95 wt % of collagen fibers, both based on the total solids content of the aqueous mixture, placing the aqueous mixture into a mold, freeze-drying the aqueous mixture while in the mold, thereby forming a collagen foam, and cross-linking the collagen foam.

The present disclosure describes a treatment composition comprising a nanoparticle composition comprising nanoparticles functionalized with surface amine groups and a crosslinking composition comprising genipin. The disclosure also describes a kit comprising the treatment composition, and instructions for using the kit to crosslink the nanoparticles to a tissue graft. The treatment composition and kit can be used to crosslink nanoparticles to a tissue graft, and the resulting tissue graft can be used to replace defective tissue in a subject in need thereof.

The present invention provides for a method of improving the release of non-steroidal anti-inflammatory drugs (NSAIDs) from a plaster or bandage comprising an adhesive layer with a pharmaceutically acceptable NSAID together with heparin or a heparinoid. The invention also provides for methods of reducing muscle hyperalgesia in subjects without spontaneous pain.

Therapeutic hydrogels in nonsurgical techniques to promote healing and regeneration of tissues whose structure and functions have been diminished due to chronic inflammatory disorders. More particularly, providing therapeutic and regenerative hydrogel compositions and their nonsurgical delivery to periodontal treatment sites to treat periodontal and peri-implant diseases. One delivery technique involves the injection of a sterile therapeutic biomimetic hyaluronic acid hydrogel tethered to at least one host modulating agent, such as tetrahydrocurcuminoids, THC, and at least one additional tissue regenerative agent, into the gingival connective tissue proper. The host modulating agent potentiates the periodontal tissue regeneration at the periodontal treatment site, while the biomimetic hyaluronic acid hydrogel serves in a dual capacity as a drug, a tissue regenerative agent carrier and as a biodegradable matrix around which the new connective tissue regenerates. Oral care gel and paste compositions may be used in a synergistic home-based oral care regimen.