Disclosed herein are compositions (e.g., sprays, paints, etc.) that comprise antimicrobial zeolite nanoparticles. Also provided are hemostatic compositions comprising zeolite nanoparticles, dryer sheets comprising zeolite nanoparticles, and textiles comprising zeolite nanoparticles. Also disclosed are compositions (e.g., sprays) that include a binder polymer to improve coating adherence. In some cases, the zeolite nanoparticles can further comprise an optical tracer (e.g., a fluorophore) associated with the zeolite nanoparticles. The optical tracer can be interrogated to confirm presence of the zeolite nanoparticles (or a coating comprising the zeolite nanoparticles) on a surface. Also provided are methods of forming viricidal coatings using compositions that comprise zeolite nanoparticles dispersed in a carrier.

A hemostatic colloid and method of forming a hemostatic colloid for dispensing into a wound site to control bleeding is provided. The hemostatic colloid is comprised of collagen in microfibril, crystalline, powder or granular form and is mixed with a liquid thrombin solution to form a flowable collagen/thrombin hemostatic colloid.

A hemostatic composition is provided. The hemostatic composition includes a hemostatically effective amount of a hemostatic agent that includes a nanoparticle and a polyphosphate polymer attached to the nanoparticle. Also provided are medical devices and methods of use to promote blood clotting.

Disclosed herein are methods relating to manufacturing an embolizing agent precursor. Manufacture of the embolizing agent precursor may involve mixing a first component contained within a first container with a second component contained within a second container, the first component including a plurality of negatively charged gaseous components and a first stabilizer, the second component comprising a plurality of positively charged oil components, a second stabilizer, and a cationic surfactant. Further steps may include mixing the first component with the second component such that the first and second component are held together as a single agglomerated entity.

The present inventors have developed printable collagen bioinks using unmodified type I collagen with mechanical and structural properties that facilitate application to tissue in a structured form. In particular, the compositions of the present invention may be used to apply collagen gels to tissue (e.g. eye) using two- or three-dimensional (extrusion) bioprinting techniques.

A sheet structure comprising two joined extracellular matrix (ECM) tissue or sheet layers and a physiological sensor disposed therebetween; the ECM tissue being derived from a mammalian tissue source that includes small intestine submucosa (SIS), urinary bladder submucosa (UBS), stomach submucosa (SS), urinary basement membrane (UBM), liver basement membrane (LBM), amniotic membrane, mesothelial tissue, placental tissue and cardiac tissue.

Hemostatic devices for promoting blood clotting can include a substrate (e.g., gauze, textile, sponge, sponge matrix, one or more fibers, etc.), a hemostatic material disposed thereon such as kaolin clay, and a binder material such as crosslinked calcium alginate with a high guluronate monomer molar percentage disposed on the substrate to substantially retain the hemostatic material material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood to accelerate clotting. Moreover, when exposed to blood, the binder has low solubility and retains a majority of the clay material on the gauze. A bandage that can be applied to a bleeding wound to promote blood clotting includes a flexible substrate and a gauze substrate mounted thereon.

The purpose of the present invention is to provide an injectable sol into a body, suited for delivery through a catheter, and usable for tissue perforation closure, ulcer protection, or vascular embolization. Provided are a sol for tissue perforation closure, a sol for ulcer protection, and a sol for vascular embolization, each containing from 0.6 mass % to 3 mass % of a collagen, water, from 200 mM to 330 mM sodium chloride, and a buffer and having a pH from 6.0 to 9.0.

In various aspects, the present disclosure pertains to methods of treating or preventing bleeding at a tissue site comprising applying a chitosan powder composition to the tissue site. In various aspects, the present disclosure pertains to chitosan powder compositions for application to a tissue site, where the powder compositions comprise a chitosan salt, a crosslinked chitosan, a derivatized chitosan, or a combination thereof. In various aspects, the disclosure pertains to catheter assemblies, which are preloaded with a chitosan powder composition and which are configured to deliver the chitosan powder composition a tissue site.

The present disclosure provides a wound dressing assembly comprising (i) a blood-clotting mold device with a mold cavity for forming a molded blood clot for use in dressing a wound. Prior to extraction, the molded blood clot is pushed towards the mold cavity's interior, which causes the molded blood clot to disassociate from the cavity walls and thereafter it can be removed with none or only minimal damage to its integrity.