A formulation of foam thermosensitive hydrogel includes a thermosensitive hydrogel including synthetic polymeric material. The thermosensitive hydrogel has properties of changing phase from liquid to solid in high temperature and changing phase from solid to liquid in low temperature. The foam thermosensitive hydrogel having a predetermined surface tension is formed after mixing the thermosensitive hydrogel with air. The foam thermosensitive hydrogel has properties of increased volume and being semisolid. After injecting the foam thermosensitive hydrogel into a human body, the foam thermosensitive hydrogel changes phase form liquid to solid after temperature rises above LCST. The foam thermosensitive hydrogel injected into the human body becomes a solid, physical barrier between an injured site and surrounding tissue, thereby preventing adhesion from forming in the human body. A method of manufacturing foam thermosensitive hydrogel is also provided.

Aspects of the invention relate to a metal material and product made from the metal material having biological properties, such as antibiotic properties.

A surface coating structure of a surgical prosthesis according to an exemplary embodiment of the present disclosure may include: a first coating layer formed on the surface of the surgical prosthesis and including an amino compound for surface adhesion; a second coating layer formed on one side of the first coating layer and including a fluorine compound conferring hydrophobicity to the surface coating structure of the surgical prosthesis; and a third coating layer formed on one side of the second coating layer and including a lubricant component for preventing adhesion of a biomaterial existing in a subject into which the surgical prosthesis is inserted.

The inventive subject matter provides compositions and methods for transiently or permanently treating or managing an injury. Contemplated compositions are polymerizable in situ over short time periods, even in the presence of blood, without undue exothermic heat. Contemplated compositions may further comprise an anesthetic, an antiseptic, an adhesion promoter, and/or a vasoconstrictor.

One aspect of the invention provides a method of preventing or reducing stenosis in a subject. The method includes implanting a passivated graft comprising vein into an artery. The implanting of the graft replaces and/or bypasses a diseased segment of the artery. The passivated graft including vein is prepared by exposing the exterior surface of the passivated graft comprising vein to a tissue structure stabilizing agent (“TSSA”) under conditions sufficient to promote cross-linking of proteins within the vein.

A biodegradable mesh implant for use in soft tissue repair, in particular surgical hernia, chronic wound healing or fistula repair, within the body of a patient is disclosed. The mesh implant includes a porous, hydrophilic biodegradable polymeric carrier mesh and fibroblasts on or within the polymeric carrier mesh. The carrier mesh includes a sponge-like structure with interconnected pores of different sizes, has a water contact angle of less than 75° and is made of at least a first polymer comprising polylactic acid as a main component.

Medical hydrogel systems for providing improved properties for certain medical applications are described. The hydrogel systems are effective for forming a space filling hydrogel in a body cavity and for the prevention of adhesion formation between tissues within the body cavity following a surgical procedure. Hydrogel delivery systems for transcervical delivery of a premixed precursor solution and an accelerator solution are described. Methods for transcervical installation of intrauterine hydrogels with distended fill are also described. The hydrogel systems, hydrogel delivery systems, and associated methods can be useful for providing degradable hydrogel in the uterine cavity, including the cervical canal, for the prevention of adhesions following intrauterine procedures.

Implantable medical product, comprising a basic body and an imidazole derivative in the form of its free base; wherein said basic body has on its polymeric surface a layer containing the imidazole derivative as an active ingredient, which displays an antithrombogenic, antiproliferative, anti-inflammatory or antiadhesive effect, or a combination thereof.

The purpose of the present invention is to inhibit and prevent the formation of adhesions, i.e., bonds between a wound and its surrounding tissues or between organs that are originally separated.

The anti-adhesion material of the present invention is characterized in that at least a part of the anti-adhesion material is made of a non-biodegradable material and a contact angle of a surface to water is less than 7 degrees or more than 90 degrees.

Provided is a self-assembling peptide, a preparation method, the self-assembling peptide formulations and use, and it is related to the field of biotechnology. The self-assembling peptide provided by the present disclosure has a general formula as shown in AC-Pro-X1-X3-X2-X3-X1-X3-X2-Pro-amide. Through experiments, the inventors of the present disclosure found that the self-assembling peptide provided by the present disclosure, because solubility is high and difficulty of synthesis and purification is less compared with a traditional self-assembling peptide, is more feasible for industrial production, and even cheaper to produce. In mass synthesis and purification, the number of purification decreases, the single purification amount increases, the purity of a crude peptide can reach 90% or more, and the cost is greatly reduced.