A medical device may include a body and a photosensitizer integrated with the body. The medical device may passively resist colonization of bacteria under ambient light. The medical device may also actively resist colonization of bacteria by releasing reactive oxidative species (ROS) in response to administration of a light dose in a range of 0.5 J/cm.sup.2 to 320 J/cm.sup.2, for a duration between 1 second and 1 hour. The body may be formed by a base resin. The photosensitizer may be compounded with the base resin. The photosensitizer may be imbibed into the base resin. The medical device may include a coating disposed on a surface of the body. The photosensitizer may be disposed within the coating. The medical device may include a catheter adapter and a catheter extending distally from the catheter adapter. The catheter may be co-extruded with the photosensitizer and another material.

Provided are formulations and related methods, for coating or impregnating a medical device, as well as a coated or impregnated medical device, for example, a device that is a catheter or cannula, where a different formulation may be used for interior surface of device and for exterior surface of the device.

The present invention relates to a compression bandage for treating wounds comprised of a linear elastic compression wrap and a sterilized polymer foam layer containing a plurality of antimicrobial dyes with at least one dye being gram positive and at least one other dye being gram negative and a biofilm reduction agent and wherein said foam is secured to said linear elastic compression wrap.

A therapeutic bandage includes a bandage matrix and an array of microneedles extending from the bandage matrix. Each of the microneedles includes a first layer that encapsulates a first immunomodulatory compound and a second layer that encapsulates a second immunomodulatory compound. The array of microneedles is configured to guide foreign agents affected by the first immunomodulatory compound, the second immunomodulatory compound, or the first and second immunomodulatory compounds from one or more skin layers of a user to the bandage matrix such that the bandage matrix absorbs and captures the foreign agents.

A formulation for manufacturing an antimicrobial article, said formulation comprising 25 to 75 weight parts of a PVC resin; 20 to 40 weight parts of a plasticizer; 10 to 30 weight parts of a solvent diluent; 0.001 tol % by weight, and preferably 0.001 to 0.3% by weight of a singlet oxygen generating dye.

A therapeutic bandage includes a bandage matrix and an array of microneedles extending from the bandage matrix. Each of the microneedles includes a first layer that encapsulates a first immunomodulatory compound and a second layer that encapsulates a second immunomodulatory compound. The array of microneedles is configured to guide foreign agents affected by the first immunomodulatory compound, the second immunomodulatory compound, or the first and second immunomodulatory compounds from one or more skin layers of a user to the bandage matrix such that the bandage matrix absorbs and captures the foreign agents.

A method for embolization of a blood vessel in a body, wherein at least one gelling component is biocompatible, biodegradable, with radiopaque capability and in liquid form to be supplied to a blood vessel by means of a single or multi lumen microcatheter and forming once in contact with a gelling agent in situ a deformable solid matrix in the body. The microcatheter may be provided with a first lumen disposed inside a second lumen. The gelling agent may be supplied to the blood vessel before the gelling component. Therapeutic compositions may be supplied to the blood vessel through the microcatheter.

Disclosed are adjustable intraocular lenses and methods of adjusting intraocular lenses post-operatively. In one embodiment, an adjustable intraocular lens can comprise an optic portion and a peripheral portion. The peripheral portion can comprise a composite material comprising an energy absorbing constituent and a plurality of expandable components. A base power of the optic portion can be configured to change in response to an external energy directed at the composite material.

Provided herein are methods for making foam materials and foam material products having a polyurethane foam matrix defining a plurality of pores, a hydrophilic agent retained within at least a portion of the pores for improving an absorption of the foam material, a salt retained within at least a portion of the pores in an amount sufficient to render the foam material isotonic, a surfactant retained within at least a portion of the pores in an amount sufficient to be released upon contact with a moist surface. Also provided herein are methods for making a multilayer foam by casting a second foam layer on a first foam layer substrate and compressing the second foam layer before the second layer is fully cured to form an interface layer in situ.

A photocurable composition for 3D printing includes a) at least one photocurable prepolymer chosen from the group consisting of functionalized gelatin bearing a first functional group and functionalized decellularized extracellular matrix bearing a second functional group; b) at least one solvent, the solvent being formamide; and c) at least one photoinitiator.