A blood bag system includes one clamp. The clamp includes a base formed with an insertion hole through which a second tube and a third tube are inserted. A first slit for pressing the outer circumferential surface of the second tube inward such that a second flow channel is closed, and a second slit for pressing the outer circumferential surface of the third tube inward such that a third flow channel is closed, are provided in a wall section forming the insertion hole.

Provided is a method for producing platelets, in which damage to platelets is suppressed compared with a method in which platelets are separated using a filter from a megakaryocyte culture, and then the platelets are concentrated using a hollow fiber membrane and are further washed using the hollow fiber membrane, and purified platelets can be produced in a shorter period of time compared with the time that is taken to perform the above-described method so as to reduce damage to platelets. The method for producing purified platelets of the present invention includes a concentrating step of concentrating a megakaryocyte culture, and a centrifuging step of centrifuging platelets from an obtained concentrate.

Embodiments are described for treating a fluid, e.g., a biological fluid. The embodiments may include systems, apparatuses, and methods. Embodiments may provide for a flow cell, with a plurality of manipulation elements, through which a fluid is flowed. The fluid may be treated (e.g., exposed to energy) as it moves through the flow cell. In embodiments, the flow cell may be used to inactivate pathogens in the fluid.

A method (and a system for implementing such method) for creating a plurality of fluid products each having a minimum content of a fluid component includes providing a plurality of intermediate fluid volumes each having a known content of a fluid component. The intermediate fluid volumes are grouped by fluid component content, followed by a determination of whether two of the intermediate fluid volumes may be pooled to achieve the minimum content for a final fluid product. The method proceeds with creating combinations of three and then more intermediate fluid volumes achieving the minimum content for a final fluid product, followed by creating combinations of intermediate fluid volumes exceeding the minimum content. Each intermediate fluid volume is assigned to only one of the combinations, with the intermediate fluid volumes being assigned to the combinations so as to maximize the number of combinations and, thus, the number of final fluid products.

A separation assembly for an apheresis system includes a first media bag, a second media mag, a vessel, and a separation set. The first media bag contains a first fluid medium. The second media bag contains a second fluid medium. The vessel is configured to contain a third fluid medium. The separation set includes a first tube and a second tube. The first tube has a first fitting that is configured to be coupled to the first media bag. The first tube defines a first length. The second tube has a second fitting that is configured to be coupled to the second media bag. The second tube defines a second length different from the first length. The separation set may further includes a third tube is configured to be coupled to the vessel.

A blood component sampling cassette which can be more efficiently manufactured at lower cost as compared to a typical cassette, a blood sampling circuit set, and a blood component sampling system. A blood component sampling cassette (22) includes a cassette main body (23) made of a soft material to which heat sterilization is applicable. The cassette main body (23) is provided with a retransfusion line (44). The retransfusion line (44) is provided with a reservoir (47) configured to temporarily store a blood component to be returned to a blood donor. The reservoir (47) is pressed by a retransfusion pump (49) to discharge the blood component from the reservoir (47).

Described is a method for controlling fluid volume balance. A controller is configured with a first set of inputs comprising a hematocrit, a total blood volume, and an ACD ratio. A maximum extracorporeal RBC amount during the procedure is estimated based on the first set of inputs. A fluid circuit is primed with a priming fluid. Whole blood is drawn from a blood source and separated into a RBC component, a target cell component, and a plasma component. The target cell component is directed to a product container. The product container comprising the target cell component is treated. A treated target cell component, a portion of the RBC component remaining in the fluid circuit, and/or a portion of the plasma component remaining in the fluid circuit are returned to the blood source. A first response action is provided if the maximum extracorporeal RBC amount estimated is above a programmed limit.

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

Method consists of placing a flexible container within a rigid frame and expanding the container by pneumatic or hydraulic pressure such that the walls of the container conform to the inside walls of the rigid frame thus forming a well-defined chamber. The system has the capability of reducing the volume of the chamber by adjusting the distance between the walls of the rigid container. The methods and systems so described are applicable to closed sterile systems that employ immunomagnetic isolation or purging of components from blood products. By providing a fixed volume and at least one surface upon which targeted entities can be magnetically deposited, target cells in the case of positive isolations can be magnetically held, flushed with wash buffers over them to remove entrapped cells and finally the recovery of product of extremely high purities and at high yields.

Provided is a medical bag hanger that hangs a plurality of bags of a blood sampling line set. The medical bag hanger includes a hanger main body that is hangable on a blood component separation device. The hanger main body includes a hook unit on which the plurality of bags is hooked, and a base plate on the surface of which the plurality of bags of the blood sampling line set are arranged side by side.