A negative-balanced isolated pelvic perfusion method, in which a drug is administered into the closed pelvis while keeping the volume of suction from the vein larger than that of injection into the artery, does not require allogeneic blood transfusion. A perfusion device is for recovering a liquid containing a drug and/or blood from a tube connecting to the inferior vena cava and for injecting the liquid obtained into a tube connecting to the artery, provided with a unit for closing the inside of the pelvis by including a unit for blocking the artery from the heart to the pelvis, a unit for blocking the inferior vena cava from the pelvis to the heart, and a unit for blocking a blood flow from the pelvis to the lower limbs. The perfusion device is provided with a pelvic perfusion unit equipped with a reservoir, an autotransfusion unit, and a dialysis unit.

Provided is a blood processing filter comprising a container having two spouts serving as an inlet for a liquid to be processed and an outlet for the processed liquid, and a filtration medium contained in the container, the filtration medium comprising a filter material having different CWST values for one surface A and the other surface B.

A method for washing a suspension of cells including a suspension fluid and a plurality of cells is provided. The method includes using centripetal force to generate a layer of wash solution against a cylindrical wall and to generate a cell suspension layer adjacent to the layer of wash solution. The method also includes forcing the cells through the layer of wash solution to generate a layer of clean cells. Devices for performing the method are also provided.

A filter assembly for filtering a body fluid comprising a filter system and a filter holder is disclosed, wherein the filter system consists of at least two layers. The first layer is a defoaming layer made of a monofilament woven open mesh fabric and with an embossed three dimensional structure configured for entrapping foam built up in the body fluid. The second layer is a mesh filter layer, and is arranged downstream of the defoaming layer. A container for collecting a body fluid comprising such a filter assembly is also disclosed.

A system for processing fluids and filling a container with a product includes a disposable fluid circuit and reusable hardware configured to accept the disposable fluid circuit. The disposable fluid circuit includes a spinning membrane separator, first and second syringes, and a flow control cassette. The reusable hardware includes a drive coupled to the spinning membrane separator, first and second syringe pumps, the first and second syringes coupled to the first and second syringe pumps respectively, and a controller. The system also includes a syringe pump for filling low-volume containers, which syringe pump may be one of the first and second syringe pumps, or may be a third syringe pump. The syringe pump for filling low-volume containers may include a filtered vacuum/pressure source and a position detector.

System and method for pathogen inactivation with UV-C light (employed by itself or in addition to filtering out particulates rom the flow of air reaching the user) by delivering, into a lightguide portion of the air inactivation chamber of the system, a dose of ultraviolet radiation sufficient for at least one log reduction level of the pathogen while, at the same time, multiply reflecting the light inside the chamber to increase the irradiance of inactivating light several fold (up to 5×, or even up to 8.6×) as compared to that delivered to the chamber.

A biological component treatment system includes a biological component kit, and a biological component treatment device in which the biological component kit is set. The biological component kit includes tubes and a biological component cassette. The biological component cassette includes a cassette main body having flow paths in the interior of the cassette main body, and the cassette main body includes flow path opening/closing units which are capable of switching between opening and closing of the flow paths. The flow path opening/closing units include cutouts provided at positions adjacent to the flow paths.

Methods and systems for priming a disposable fluid circuit for the processing of a biological fluid are disclosed. The methods and systems allow for variable and configurable priming of the flow path(s) leading to one or more biological fluid source containers.

A system for washing red blood cells, comprising a separator configured to separate a quantity of blood into concentrated red blood cells having a hematocrit of at least 60% and a volume of 150-250 mL, and a supernatant component. The system comprises a flow controller configured to remove the supernatant component to provide an initial red blood cell concentrate; combine 50-500 mL of an additive solution with the red blood cell concentrate to provide an intermediate red blood cell product intended for storage for 42 days or less; and wash the intermediate red blood cell product with a washing solution.

Apparatus and methods for concentrating platelet-rich plasma is described herein. One variation may generally comprise a tube having a length and defining a channel within and one or more ports located at a proximal end of the tube and in fluid communication with the channel. A plunger may slidably translatable within the channel while forming a seal against an inner surface of the channel and a float may have a pre-selected density and defining a concave interface surface, wherein the float is slidably contained within the channel such that the concave interface surface is in apposition to the one or more ports.