A hollow fiber membrane for separating blood plasma from blood, comprising a blood contact layer and a support layer each comprising a hydrophobic polymer, a hydrophilic polymer and vitamin E, and a method for producing said hollow fiber membrane to provide a hollow fiber membrane is described. The hollow fiber membrane is characterized by a reduced hemolysis activity so that the hollow fiber membrane can be advantageously used in plasmapheresis methods.

A blood filtration system can reduce the amount of plasma constituents (e.g., water and/or electrolytes) in the blood of the patient, and accordingly increase the hematocrit value of the patient. The blood filtration system (e.g., a controller, or the like) can determine a hematocrit value of a patient. The blood filtration system can determine a venous pressure of vasculature of a patient. The blood filtration system can compensate for pressure head in a component of a blood circuit (e.g., a withdrawal line of a catheter), for example to improve the accuracy of the venous pressure determination. The blood filtration system can determine one or more resistance characteristics of a blood circuit for the blood filtration system. The resistance characteristics can correspond to a resistance to a flow of blood through a component of the blood circuit.

Materials and methods for improving immunotherapy are provided herein. In some cases, the materials and methods can be used in the treatment of cancers.

An apheresis system includes a chamber configured to receive a centrifuge assembly and a moving loop holder. The moving loop holder includes a loop holder that has a loop connection that is configured to interact with a flexible loop received by the centrifuge assembly. The moving loop holder is configured to move between a first position and a second position, where in the first position, the moving loop holder is a first distance from the centrifuge assembly, and in the second position, the moving loop holder is a second distance from the centrifuge assembly. The centrifuge assembly is prevented from moving from an operating state to a loading state when the moving loop holder is in the first position, and the centrifuge assembly is allowed to move from the operating state to the loading state when the moving loop holder is in the second position.

The invention provides apheresis devices and their use for removal of substantially all types of cell free DNA (cfDNA) in patients' blood, including nucleosome-bound cfDNA, exosome-bound cfDNA and unbound cfDNA (including double stranded DNA (dsDNA), single stranded DNA (ssDNA) and oligonucleotides), to limit the negative effects of the circulating cfDNA and to treat various diseases.

A load cell assembly includes a load cell and a deflection portion. The load cell includes a fixed end and a free end. The free end is configured to receive a force in a first direction. The deflection portion includes a first component and a second component. The first component is coupled to the free end of the load cell. The first component defines a first cam surface. The second component is configured to support the vessel. The second component defines a second cam surface. The second cam surface is configured to engage the first cam surface. In an engaged state, the second cam surface is in continuous direct contact with the first cam surface. In a disengaged state, at least a portion of the second cam surface is disengaged from the first cam surface. The load cell assembly includes a central axis.

A collection bottle includes a lid and a canister. The canister has a closed end and an opened end and defines an interior space. The lid includes a lid body having a first side and a second side, a shield handle, and one or more ports. The first side of the lid body is configured to be coupled to the open end of the body to close the interior space. The shield handle and the one or more ports extend from the second side of the lid body. The shield handle extends a first distance from the second side of the lid body. The one or more ports extend a second distance from the second side of the lid body. The first distance is greater than the first distance.

A method includes receiving, with an apheresis system, data associated with a donor; determining, based on the data associated with a donor, an identification of the donor; receiving, with the apheresis system, data associated with a blood component collection set; receiving, with the apheresis system, data associated with a plasma collection bottle; and performing, with the apheresis system, a plasma donation process based on the identification of the donor, the data associated with the blood component set, and the data associated with the plasma collection bottle. Receiving the data associated with the donor may include scanning, with a scanner, an image. The scanner is disposed on the apheresis system and the image may include one of a one-dimensional barcode or a two-dimensional barcode. The data associated with the donor may be displayed on a user device.

An apheresis system may include an assembly for separating a component from a multi-component fluid, a processor, and a memory storing data for processing by the processor. The data, when processed, may cause the processor to run a calibration test on one or more instruments of the assembly and, based the one or more instruments failing the calibration test, calibrate the one or more instruments or lock the apheresis system for non-use. The apheresis system may include a pump configured to generate a calibration pressure at a test port and a pressure sensor configured to sense a pressure at the test port. The calibration test may include comparing the calibration pressure at the test port to the sensed pressure by the pressure sensor at the test port.

A soft cassette includes a body including a flexible material and first and second component. The body defines first and second lumens and first and second chambers. The first lumen extends between first and second ends. The first chamber is in the first lumen such that fluid passing through the first lumen passes through the first chamber. The second lumen is fluidly connected to the first lumen at a first junction between the first end and the first chamber and a second junction between the second end and the first chamber such that fluid passing through the second lumen bypasses the first chamber. The second chamber is in the second lumen. The first component is on a first side of the second chamber and includes a first ferromagnetic metal or magnet. The second component is on a second side of the second chamber and includes a second ferromagnetic metal magnet.