A perfusion system includes a fluid reservoir configured to hold a portion of fluid, the portion of fluid having a volume, the fluid reservoir having a total capacity that is greater than the volume; an imaging device, the imaging device configured to obtain image data corresponding to the fluid reservoir; and a controller. The controller is configured to receive the image data from the imaging device; determine the volume based on the image data; and facilitate control, in response to at least one of a user input and the determined volume of the portion of fluid, of an operating parameter corresponding to the fluid reservoir to facilitate changing or maintaining the volume of the portion of the fluid.

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

A bidirectional vascular cannula device includes a tube and a moving mechanism having a through hole. The tube includes a tubular wall which defines therein a passage having opposite proximal and distal opened ends. The tubular wall has a secondary opening formed therethrough. Oxygenated blood infused into the passage from the proximal opened end is delivered to one end of the blood vessel from the distal opened end, and a part of the blood is delivered to the other end of the blood vessel through the secondary opening and the through hole so as to obviate ischemic caused by cannula occlusion. The moving mechanism is operable to be moved to permit a part of the moving mechanism to project outwardly and to be attached to the inner wall of the blood vessel for positioning the cannula device.

The invention relates to a device for extracorporeal blood treatment, comprising a blood treatment unit 1 that comprises at least one compartment 4. The invention further relates to a method for determining a hemodynamic parameter during an extracorporeal blood treatment by means of an extracorporeal blood treatment device. In order to determine the hemodynamic parameter, the conveying direction of the blood pump 10 is reversed from a “normal” blood flow to a “reversed” blood flow. In practice, it has been found that reversing the conveying direction of the blood pump for a measurement for determining a hemodynamic parameter carries the risk of blood clots reaching the patient, despite the dialyser holding back blood clots. The blood treatment device comprises an input unit 23 for inputting a time interval which can be specified by the user, taking into account the patient-specific and system-specific factors. The control and evaluation unit 12 of the blood treatment device is configured such that the operation of the blood pump 10 in the operating mode involving a reversed blood flow is only enabled during the time interval input by means of the input unit, the start of the time interval being determined from the point at which the blood treatment starts.

A dialysis system includes a dialysis apparatus, a measurement apparatus, and a control apparatus. The dialysis apparatus performs hemodialysis on a dialysis subject. The measurement apparatus measures a cerebral regional oxygen saturation of the dialysis subject. The control apparatus adjusts a hemodialysis operating condition by the dialysis apparatus so as to suppress decrease in the cerebral rSO2 based on the cerebral rSO2 of the dialysis subject measured by the measurement apparatus during operation of the hemodialysis by the dialysis apparatus.

A method is provided for the real time calibration of a pump that is part of a reusable hardware component having a programmable controller during a blood separation procedure where fluid is flowed through a tubing in a tubing set by action of the pump. The method comprises programming the controller with a continuous function defining a relationship between pump inlet pressure and pump stroke volume; commencing the fluid processing procedure to operate the pump to draw fluid through the tubing; measuring fluid pressure in the tubing at the inlet of the pump; calculating a current pump stroke volume with the controller based on the continuous function and the pump rotational rate; and adjusting the pump rotational rate utilized by the controller to control the procedure to achieve a target fluid flow rate. The continuous function defining the relationship between pump inlet pressure and the pump stroke volume may be empirically determined over a predetermined range of inlet pressures.

A control system controlling blood gas values in blood processed by an oxygenator, wherein the oxygenator generates arterial blood by exposing venous blood to oxygen from an oxygenation gas supply, comprises a monitoring arrangement to determine a level of the blood gas values in the arterial blood and a controller that is responsive to the monitoring arrangement and configured to control parameters of the oxygenation gas supply to the oxygenator. This allows the blood gas values to be adjusted toward a pre-determined level.

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

A method of collecting plasma includes receiving donor parameters at a controller of a plasma collection device electronically from a donor management system. The method includes storing a target volume for raw plasma which is based at least in part on donor height and weight used to calculate total donor blood volume, the target volume for raw plasma based on the total donor blood volume. The method includes setting the target volume for raw plasma and controlling the plasma collection device to operate draw and return phases to withdraw whole blood from a donor and separate the whole blood into the plasma product and a second blood component comprising red blood cells and to return the second blood component to the donor. The controller operates the draw and return phases until a volume of raw plasma in the collection container equals the target volume of raw plasma.

A system for controlling the position of a diaphragm in a diaphragm-containing pressure pod, is provided. The system can include a peristaltic pump, a pressure pod having a flow-through fluid side and a gas side that are separated by a diaphragm, and a pressure sensor operatively connected to the gas side. The pressure sensor is configured to sense pulses of pressure resulting from movement of the diaphragm and caused by the action of the peristaltic pump. A gas source and a valve can be in fluid communication with the gas side of the pressure pod and can be configured to provide gas to, or vent gas from, the gas side. A controller receives pressure signals from the pressure sensor and controls the valve in response, and in so doing, controls the position of the diaphragm. Methods for positioning the diaphragm are also included.