An assembly of the present invention for a syringe is composed of a barrel, made of cyclic polyolefin, which has a barrel body having a distal end part and a piercing needle which has a piercing needle tip at its distal end and is fixed to a piercing needle fixing portion of the barrel and a seal cap mounted on the barrel. The seal cap is formed of a thermoplastic elastomer composition containing as its main component a mixture of a styrene-based thermoplastic elastomer and a softener, for hydrocarbon-based rubber, which has a kinematic viscosity of 1 to 5,000 mm.sup.2s.sup.1 at 100 degrees C. and a naphthenic carbon ratio (% CN) of not more than 20% when said naphthenic carbon ratio is measured by ring analysis.

A substance delivery device that includes a hypodermic needle with a tube for receiving and containing a volume of a substance. The substance delivery device includes a rod, a portion of which is of a size and shape to fit within the tube of the hypodermic needle. The rod can be displaced into and within the tube to contact and apply a force to a volume of substance contained within the tube to cause, at least in part, the volume of substance to be discharged out of the tube. The substance delivery device includes a rod displacement mechanism that applies a force to the rod to cause the rod to be displaced into and within the tube. The substance delivery device also includes a needle retraction mechanism that is configured to apply a force to the hypodermic needle to cause the hypodermic needle to retract from within a patient.

Disclosed in some forms is a process of limiting the impact of surgery on a nerve, the process comprising applying a therapeutic substance to the nerve during surgery. In some aspects, disclosed is a formulation for reducing nerve trauma comprising an active pharmacological ingredient adapted to intervene in the activation of pathways of cellular degradation within the nerve and a carrier adapted to reduce dissemination of the active pharmacological ingredient beyond the site at which its effect is intended.

An assembly of the present invention for a syringe is composed of a barrel, made of cyclic polyolefin, which has a barrel body having a distal end part and a piercing needle which has a piercing needle tip at its distal end and is fixed to a piercing needle fixing portion of the barrel and a seal cap mounted on the barrel. The seal cap is formed of a thermoplastic elastomer composition containing as its main component a mixture of a styrene-based thermoplastic elastomer and a softener, for hydrocarbon-based rubber, which has a kinematic viscosity of 1 to 5,000 mm.sup.2s.sup.1 at 100 degrees C. and a naphthenic carbon ratio (% CN) of not more than 20% when said naphthenic carbon ratio is measured by ring analysis.

Apparatus and methods for inserting a medicament into a body cavity are described. The apparatus comprises an elongate tube with a plunger rod therein. The plunger rod has at least one projection which cooperatively interacts or engages with at least one discontinuity on the inside of the elongate tube so that proximal movement of the plunger rod with respect to the elongate tube expels the medicament into the body cavity.

Disclosed in some forms is a delivery device for delivering a gel or liquid pharmaceutical to a treatment site, the delivery device including a body extending from a delivery tip, the body defining a cavity for retaining a pharmaceutical or a pre-assembled cartridge holding the pharmaceutical; and a driver for mechanically discharging the pharmaceutical from the cartridge to the delivery tip. In some forms the driver is adapted to release a consistent flow of the pharmaceutical. In some forms the delivery device is biased into a release configuration.

An injection device kit for the self-administration of an injection of solution that includes a body portion configured for engagement with a cartridge containing the solution and an injection needle where the body portion includes an injection component having an actuation mechanism for inserting the injection needle of the cartridge and for injecting the solution in the cartridge and a safety mechanism on the body portion and configured to prevent injection unless released.

A substance delivery device that includes a hypodermic needle with a tube for receiving and containing a volume of a substance. The substance delivery device includes a rod, a portion of which is of a size and shape to fit within the tube of the hypodermic needle. The rod can be displaced into and within the tube to contact and apply a force to a volume of substance contained within the tube to cause, at least in part, the volume of substance to be discharged out of the tube. The substance delivery device includes a rod displacement mechanism that applies a force to the rod to cause the rod to be displaced into and within the tube. The substance delivery device also includes a needle retraction mechanism that is configured to apply a force to the hypodermic needle to cause the hypodermic needle to retract from within a patient.

A. An injection device kit for the self-administration of an injection of solution that includes a body portion configured for engagement with a cartridge containing the solution and an injection needle where the body portion includes an injection component having an actuation mechanism for inserting the injection needle of the cartridge and for injecting the solution in the cartridge and a safety mechanism on the body portion and configured to prevent injection unless released.

The invention provides for a delivery system including a delivery assembly configured to allow delivery of a single dose of a therapeutic agent (e.g., vaccine, drug, medicament, etc.) from a Blow-Fill-Seal (BFS) vial to a patient.