An implantable cranial medical device includes a first fluid flow path, a second fluid flow path, and upper flange portion, and a lower portion. The upper flange portion is configured to rest on a skull of a subject about a burr hole. The lower portion is configured to be placed within the burr hole. The first fluid flow path may extend from a first opening in the upper flange portion to a first opening in the lower portion. The second fluid flow path may extend from a second opening in the upper flange portion to a second opening in the lower portion.

An implantable cranial medical device includes a first fluid flow path, a second fluid flow path, and upper flange portion, and a lower portion. The upper flange portion is configured to rest on a skull of a subject about a burr hole. The lower portion is configured to be placed within the burr hole. The first fluid flow path may extend from a first opening in the upper flange portion to a first opening in the lower portion. The second fluid flow path may extend from a second opening in the upper flange portion to a second opening in the lower portion.

A delivery device for delivering medicament, such as insulin, to a patient includes a housing and a base enclosing an inner cavity. Enclosed within the housing is a reservoir for containing a medicament, a delivery mechanism for delivering the medicament to the patient, and a pump in fluid communication with the reservoir and delivery mechanism. The base has an integrally formed fluid channel in fluid communication with the reservoir and the delivery mechanism and a filter media containing an adsorbent positioned in the fluid channel to contact the medicament and remove at least a portion of a stabilizing compound from the medicament carried through the fluid channel.

Modular intravenous (IV) assemblies are provided. The modular IV assembly includes a drip chamber having a body and an inlet connector, a base housing coupled directly to a base portion of the drip chamber, the base housing having an inlet port in fluid connection with the drip chamber and a flow path cavity in fluid connection with the inlet port and a flow control assembly coupled directly to a first portion of the base housing. Any of a filter assembly, an anti-run dry member, a check valve and an air vent assembly may be included in the modular IV assembly. IV sets and methods of use are also provided.

Modular intravenous (IV) assemblies are provided. The modular IV assembly includes a drip chamber having a body and an inlet connector, a base housing coupled directly to a base portion of the drip chamber, the base housing having an inlet port in fluid connection with the drip chamber and a flow path cavity in fluid connection with the inlet port and a flow control assembly coupled directly to a first portion of the base housing. Any of a filter assembly, an anti-run dry member, a check valve and an air vent assembly may be included in the modular IV assembly. IV sets and methods of use are also provided.

IV filters are described herein. An IV filter includes a filter housing, a filter media, a filter channel, a priming channel, and a disk valve. The filter housing defines an inlet and an outlet. The filter media is disposed within the filter housing. The filter channel is disposed within the filter housing. The filter channel is in fluid communication with the inlet and the filter media, and the filter media permits flow from the filter channel to the outlet and captures particulate from the flow. The priming channel is disposed within the filter housing. The priming channel is in fluid communication with the inlet and the outlet. The disk valve is coupled to the filter housing. The disk valve is moveable to direct flow from the inlet to the priming channel in a first position and to direct flow from the inlet to the filter channel in a second position.

IV filters are described herein. An IV filter includes a filter housing, a filter media, a filter channel, a priming channel, and a disk valve. The filter housing defines an inlet and an outlet. The filter media is disposed within the filter housing. The filter channel is disposed within the filter housing. The filter channel is in fluid communication with the inlet and the filter media, and the filter media permits flow from the filter channel to the outlet and captures particulate from the flow. The priming channel is disposed within the filter housing. The priming channel is in fluid communication with the inlet and the outlet. The disk valve is coupled to the filter housing. The disk valve is moveable to direct flow from the inlet to the priming channel in a first position and to direct flow from the inlet to the filter channel in a second position.

Hydrophilic flat-sheet membrane based on a hydrophobic first polymer from the group consisting of aromatic sulfone polymers and a hydrophilic second polymer, wherein the membrane has a thickness in the range between 30 and 200 μm, a first and a second surface and a supporting layer having a three-dimensional sponge-like network structure, wherein the supporting layer has a first cover layer on the side thereof facing the first surface and a second cover layer on the side thereof facing the second surface, which cover layers are formed integrally with the supporting layer, and wherein the first and second surfaces have approximately oval or circular openings which penetrate the first and second cover layers, respectively, and are connected to the supporting layer, wherein the average diameter of the openings in the surfaces differ by a factor of less than 2, wherein the three-dimensional network structure of the supporting layer is made up of thick branches and a continuous pore system, and the predominant proportion of the branches have a diameter of at least 0.5 μm at the thinnest point thereof and wherein the pores in the supporting layer are larger than the openings in the surfaces.

Hydrophilic flat-sheet membrane based on a hydrophobic first polymer from the group consisting of aromatic sulfone polymers and a hydrophilic second polymer, wherein the membrane has a thickness in the range between 30 and 200 μm, a first and a second surface and a supporting layer having a three-dimensional sponge-like network structure, wherein the supporting layer has a first cover layer on the side thereof facing the first surface and a second cover layer on the side thereof facing the second surface, which cover layers are formed integrally with the supporting layer, and wherein the first and second surfaces have approximately oval or circular openings which penetrate the first and second cover layers, respectively, and are connected to the supporting layer, wherein the average diameter of the openings in the surfaces differ by a factor of less than 2, wherein the three-dimensional network structure of the supporting layer is made up of thick branches and a continuous pore system, and the predominant proportion of the branches have a diameter of at least 0.5 μm at the thinnest point thereof and wherein the pores in the supporting layer are larger than the openings in the surfaces.

A composite media includes a stack with 20 or more layers, each layer including a substrate with a first major surface and an opposing second major surface; and a fiber layer deposited onto the first major surface of the substrate and including polymeric fibers with a diameter of 100 nm to 1.5 μm. Each fiber layer independently has a thickness of 5 μm to 100 μm, and each layer independently has a pore size of 0.1 μm to 10 μm. A filter may include a housing and the composite media disposed within the housing. The filter may be a syringe filter.