Nested piston apparatus is disclosed for making free pistons used to provide multi-chamber mixing and sequential delivery syringes within conventional syringe barrels. Each such syringe comprising one or more free pistons made according to the instant invention whereby syringe contents are selectively kept disparate until acted upon by forced displacement of an associated plunger rod. As well, nested piston apparatus is disclosed for using nested piston apparatus as multiple free pistons for making triple chamber syringes.

Proposed is a syringe for dermis regeneration, the syringe including: an injection unit having a first space therein and being open at a rear end portion, the first space being filled with a liquid or a gas and communicating with the outside; a needle combined with a front end portion of the injection unit and having a space therein, the space communicating with the first space; a liquid supply unit having a first end portion removably combined with the rear end portion, having a second end portion through which a piston moves, and having a space therein, the space being filled with the liquid and communicating with the first space, and the piston being inserted into the liquid supply unit; and a gas injection port passing through a sidewall of the injection unit and communicating with the first space to allow the first space to be filled with the gas.

An infusion set check valve assembly includes a self-contained housing that defines inlet ports and an outlet port. The assembly also includes at least one check valve disposed within the self-contained housing between the outlet channel and at least one of the inlet ports. The at least one check valve is configured to open for a first fluid to flow from a first inlet to a patient line via an outlet channel while a second fluid also flows from a second inlet to the patient line via the outlet channel. The at least one check valve closes to prevent the first fluid from flowing to the patient line via the outlet channel while the second fluid flows to the patient line.

A medication delivery device is disclosed. The medication delivery device comprises a housing, a drug container holder arranged at least partly within the housing, wherein the drug container holder is configured to receive a plurality of single dose drug containers each of which is configured to contain a liquid, and an actuator element configured to separately administer a single dose of the liquid from each of the plurality of single dose drug containers. Further, a medication delivery assembly, a method for manufacturing a medication delivery device and a method for administration a single dose of a liquid using a medication delivery device are disclosed.

Systems and methods of micro-infusion of medical fluids are disclosed. Micro-infusion systems may include a pump, a patient interface, tubing between the pump and the interface, and a micro-infusion device along the tubing. A first portion of the tubing above the micro-infusion device is longer than a second portion of the tubing below the device. The micro-infusion device may include a chamber in-line with the tubing, a first valve between the chamber and the first portion of the tubing, a second valve between the chamber and the second portion of the tubing and a third valve between the chamber and a dump chamber. The second valve may be slidably disposed within the chamber. A medical fluid may be provided into the chamber that slides the second valve displacing another fluid in the chamber through the third valve into the dump chamber.

Embodiments of a syringe-based device for delivering fluid include a housing, a port, the port being positioned at about the distal end of the housing, a plunger assembly, the plunger assembly including, a plunger seal, a valve, and a cannula, a first fluid reservoir, where the first fluid reservoir retains a first type of fluid, a syringe including a syringe body, a syringe port, a plunger, and a second fluid reservoir, the second fluid retaining a second type of fluid, and where the syringe transitions from a first configuration in which a first portion of the first fluid type is delivered through the port, to a second configuration in which the second type of fluid in the second fluid reservoir is delivered through the port, to a third configuration in which a second portion of the first fluid type is delivered through the port.

An infusion apparatus including a body having an infusion reservoir and one end of the body adapted to receive a pierceable end of a vial, a barrel rotatably disposed in an opposing end of the body and having an internal fluid chamber, and a plunger received in one end of the barrel, wherein the barrel rotates relative to the body between a first position allowing bi-directional fluid flow between the barrel and the vial, and a second position allowing bi-directional fluid flow between the barrel and the infusion reservoir, and wherein the plunger is movable relative to the barrel to control the bi-directional fluid flow between the barrel and the vial and the bi-directional fluid flow between the barrel and the infusion reservoir.

In one aspect, a connector assembly includes a delivery conduit defining a conduit lumen and a securable connector configured to secure the delivery conduit to a medical device hub defining a medical device hub lumen. The conduit lumen includes a constant diameter region along a portion of the delivery conduit and a transition region extending from the delivery conduit to the distal end. A transition region diameter of the transition region gradually increases from the constant diameter region to a distal end of the delivery conduit. The securable connector is coupled to an outer surface of the delivery conduit and is slidable along a portion thereof. The securable connector is configured to receive the medical device hub. The securable connector is secured relative to the delivery conduit so as to fluidically couple the conduit lumen with the medical device hub lumen.

A syringe-based device includes a housing, the housing including a port, and an actuator mechanism including a first member and a second member configured to be movably disposed within the housing. The first member includes a syringe body and a plunger movably disposed within the syringe body and including a first plunger seal. The second member includes a second plunger seal defining a channel and a valve fluidically coupled with the channel of the second plunger seal. The device also includes a first fluid reservoir and a second fluid reservoir. The device transitions from a first configuration to a second configuration in which a first type of fluid in the first fluid reservoir is delivered through a port, to a third configuration in which a second type of fluid within the second fluid reservoir is delivered through the port.

A system for serially injecting liquids includes a syringe body, proximal and distal stopper members disposed in the syringe body, a first liquid in a distal chamber, a second liquid in a proximal chamber, a plunger member, and a needle hub assembly coupled to a distal needle interface of the syringe body. The plunger member includes a needle retention feature disposed in a plunger interior, an energy-storage member disposed in the plunger interior, and an energy-storage member latching member disposed in the plunger interior. The needle assembly includes a needle having a needle proximal end feature, a hub, and a needle latching member configured to couple the needle to the hub. Manipulating the plunger member to insert the proximal stopper member distally relative to the syringe body initially expels the first liquid, then the second liquid. The needle is at least partially retractable into plunger interior.