Exemplary embodiments provide wearable automatic injection devices for subcutaneously injecting a therapeutic agent into a patient's body at controlled rates, for example, in a single bolus. Exemplary embodiments provide methods for assembling wearable automatic injection devices for subcutaneously injecting a therapeutic agent into a patient's body at controlled rates. Exemplary embodiments provide methods for using wearable automatic injection devices for subcutaneously injecting a therapeutic agent into a patient's body at controlled rates.

Devices, systems and methods for controlling, regulating, altering, transforming or otherwise modulating the delivery of a substance to a delivery site. The devices, systems and methods optimize the delivery of the substance to an intended site, such as a vessel, vascular bed, organ and/or other corporeal structures, while reducing inadvertent introduction or reflux substance to other vessels, vascular beds, organs, and/or other structures, including systemic introduction.

A dispensing device which disperses medicate through a needle across a zone within a body. The device includes a needle which is, during use, becomes encapsulated within a tubular needle-receiving member, a reservoir in fluid communication with the needle, positioned within the housing, and in communication with the needle, a second reservoir, a reservoir-connecting conduit in communication with the reservoir, a fluid drive in communication with the fluid in the second reservoir and in communication with the reservoir-connecting conduit, and a linear drive attached to the needle or to the needle-receiving member. The fluid drive impel fluids from the second reservoir to the reservoir-connecting conduit and thus drives the therapeutic agent from the reservoir during the linear displacement of the needle towards the housing. Fluid communication from the therapeutic agent reservoir to the needle is maintained by the tubing during operation of the linear drive.

In an aspect, the present invention is directed to a ball lock assembly comprising a retention pin for use with an injection device. The ball lock assembly includes a ball lock frame and a ball lock core housed within the ball lock frame that includes a longitudinal opening within which a portion of the pin is positioned. In other aspect, the present invention is directed to an injection device that includes the ball lock assembly of the present invention and a method of using the same.

The present invention provides a method for generating an immune response in a subject, comprising administering to the subject's skin an immunizing composition from a SARS-CoV-2 pathogen, wherein the composition is administered with a microneedle delivery device.

A system and method for monitoring the pressure of an injection site, utilizing a fluid operating in the laminar regime flowing through a calibrated tube, and measuring a pressure at one end of the calibrated tube with a pressure sensor, as well as a fluid velocity with a flow sensor, such as an elastic filament velocimeter, that comprises a nano-scale sensing element. Additional elements may be utilized, including the use of data acquisition units, processors, user interfaces, pumps, syringes, and control loops.

A controller assembly of a fluid delivery apparatus includes a body component and a plunger component slidably coupled to the body component. The plunger is positionable between a first position in which the plunger is nearest to the body component, and a second position in which the plunger component is furthest from the body component. A bias assembly positioned between the body component and the plunger component applies a two stage force profile to the plunger component. The bias assembly includes a first and a second biasing member. In the first position, the first and second biasing members apply first and second forces profiles, respectively, to the plunger component. In the second position, the first biasing member is prevented from applying the first force profile to the plunger component, and the second biasing member applies the second force profile to the plunger component.

An irrigation system for anal or stomal irrigation includes a tubing system attachable between a reservoir and a catheter. The tubing system has a proximal portion attachable to the reservoir and a distal portion including a distal end that is attachable to the catheter, with the tubing system providing an irrigation flow path from the proximal portion attachable to the reservoir through the distal end attachable to the catheter. A pump is operable to move the liquid through the irrigation flow path to provide the anal or stomal irrigation out of the catheter. A pressure control device is attachable to the distal portion of the tubing system and communicates with the catheter. The pressure control device has a valve that is adapted to limit an irrigation pressure for the anal or stomal irrigation out of the catheter to a value less than a pre-determined pressure threshold.

The present invention discloses a pump for measuring a pressure of fluid to be transferred, a fluid transport system using the same, and a method for operating the system. The pump includes a pumping portion alternately generating a positive pressure and a negative pressure; a first diaphragm which is provided on one side of the pumping portion and of which a shape is changed as the positive pressure and the negative pressure are alternately generated; a transport chamber which sucks and discharges a transport target fluid corresponding to the deformation of the first diaphragm; a second diaphragm which is provided on the other side of the pumping portion; a monitoring chamber which is provided on one side of the second diaphragm and of which a pressure changes corresponding to the deformation of the second diaphragm; and a pressure measuring portion measuring a pressure change of the monitoring chamber.

Syringe for dispensing medical foam having a substantially cylindrical barrel with a nozzle at its forward end and a plunger with a substantially cylindrical shaft disposed within the barrel. A flexible annular flange is provided on the inner surface of the barrel which extends toward the nozzle to contact the shaft and form a seal between the barrel and the plunger.