A dual lumen cannula is provided for conveying a fluid into an injection site through an inner lumen of the cannula. Fluid pressure is relieved from the injection site via a plurality of egress ports located along an outer lumen of the cannula.

A method for readying a fluid sensor associated with a medical device includes attaching a flow restrictor to a fluid outlet of the fluid sensor. The fluid sensor includes a fluid channel, a fluid inlet at a first end of the fluid channel configured to couple to an outlet of an administrable fluid source, and the fluid outlet at a second end of the fluid channel. Fluid is delivered from the administrable fluid source to the fluid channel through the fluid inlet. A syringe actuation device including a force limiting device may be used to deliver the fluid. The fluid is pressurized in the fluid channel between the fluid inlet and the flow restrictor to wet an interior surface of the fluid channel with the fluid. The flow restrictor is removed from the fluid outlet.

An injection device (10) for administering a liquid has a barrel (12) with an outlet (20) for the liquid, and a piston (14) arranged in the barrel (12). The piston is designed to force the liquid out from the outlet (20) by displacement into the barrel (12). The injection device (10) has an overpressure protection with a sensor (24) and with an actuator (26). The sensor (24) detects the pressure of the liquid in the barrel (12) directly or indirectly. The actuator (26) prevents a further increase in the pressure of the liquid.

A method of bariatric embolization includes deploying an intravascular pressure modulating device at a target location, operating the pressure modulating device to reduce pressure within the fundus, and infusing an embolizing agent into the fundus. Use of the pressure modulating device prevents delivery of the embolizing agent into proximal and distal non-target vessels. The method takes advantage of unique flow and pressure dynamics of the arterial vessels in the stomach.

A method of harvesting bone marrow, including percutaneously introducing a multi-lumen cannula into a cancellous bone, applying suction through a first passage defined in a first lumen of the cannula, injecting a thick flowable material into the bone from a second passage in a second lumen of the cannula, extruding the thick flowable material through a distal end of the cannula into the cancellous bone in order to displace the bone marrow and other bone fluids, the suction applied through the first passage providing a hydraulic force guiding the displaced bone marrow and collecting the displaced bone marrow for a therapeutic or diagnostic purpose. A thick flowable material for use in harvesting bone marrow in the cancellous portion of a bone and a method for percutaneously preparing a bone with a multi-lumen cannula and an inflatable device are also discussed.

A system includes a tubing set and a drive assembly. The tubing set includes inlet tubing couplable to a source of fluid, a valve coupled to the inlet tubing, a syringe coupled to the inlet tubing via the valve, and outlet tubing coupled to the valve. The valve is configured to allow fluid to be drawn from the source of fluid via the inlet tubing into a syringe body of the syringe and to be expelled from the syringe body and through the outlet tubing, and to prevent fluid from being drawn from the outlet tubing into the syringe body and to prevent fluid expelled from the syringe body from flowing through the inlet tubing. The drive assembly is configured to reversibly receive the tubing set such that a drive mechanism is engaged with a plunger of the syringe to reciprocally translate the plunger relative to the syringe body.

Apparatuses, systems and methods are provided that characterize a rear sub-assembly for an autoinjector (AI). Apparatuses, systems and methods are also provided that generate injection time (IT) models for autoinjectors (AIs). Autoinjectors (AIs) (e.g., mechanical AIs, spring-loaded AIs, etc.), components for use within AIs (e.g., prefilled syringes (PFS), rear sub-assemblies (RSAs), etc.), and related methods may utilize mathematical modeling along with design for six sigma (DFSS) and design for reliability and manufacturability (DRM) to establish upstream controls that ensure injection time (IT) robustness of mechanical autoinjectors (AIs). For example, break-loose and extrusion (BLE) alert limit, rear sub-assembly (RSA) area under the curve (AUC), and RSA minimum force.

The present invention relates to methods and systems for accurately measuring the injection pressure of a filler into the arterial vessels of the body for functional and/or cosmetic procedures, and maintaining this injection pressure below a desired pressure. For example, the injection pressure may be kept below a specific patient's diastolic blood pressure, hence reducing or negating the incidence of function-threatening embolism into a subsequent artery due to retrograde substance injection. A pressure transducer may be desirable to intrinsically control the injection pressure in response to the applied pressure on the syringe (e.g. via a plunger or other actuator). Ideally, a device (e.g. specifically tailored with properties to a specific material being injected) which consistently limits the injection pressure to being lower than an intended value is desirable, such as through intrinsic response by a pressure transducer.

An infusion device includes a housing with an interior chamber sized and configured to hold at least a flange and plunger of a syringe, a trigger held by the housing, and a lever in communication with the trigger and including an upwardly extending cam with a cam path having an upper end. The cam is in communication with the flange of the syringe. In response to actuation of the trigger to dispense fluid from the syringe, the upper end of the cam travels upward above the syringe and longitudinally toward a dispensing end of the syringe to linearly translate the plunger of the syringe in a first direction to dispense fluid from the syringe. To refill fluid into the syringe, the upper end of the cam travels downward and longitudinally away from the dispensing end of the syringe to linearly translate the plunger in a second direction to intake fluid.

A free-jet dosing system for administering a fluid into or under the skin having a micropump and a nozzle arranged on the outlet side. The micropump has an inlet and an outlet and is configured to transport a fluid from the inlet to the outlet and to generate a blocking pressure of at least 20 bar at the outlet. The nozzle is configured to output the fluid output at the outlet as a free jet at a fluid pressure so that the fluid of the free jet may be injected into the skin.