The present disclosure provides systems and methods for delivering a gel to a surface. In one embodiment, the system may have a first vessel with a first low viscosity aqueous solution comprising a binder/crosslinking agent; and a second vessel with a second low viscosity aqueous solution comprising a gelling component. The separate first and second low viscosity aqueous solutions are sprayed onto a surface where the solutions mix forming a gel.

The present disclosure provides systems and methods for disrupting the outer membrane of an oocyst in solution and delivering the solution to an animal. The system includes a vessel containing unbroken oocysts in solution, an oocyst processing chamber, and a delivery outlet. The unbroken oocysts are moved from the vessel through the processing chamber and a portion of the oocyst membranes are disrupted releasing sporocysts, the resulting solution is moved from the processing chamber into the delivery outlet where the solution is delivered to an animal. Methods of vaccination, including vaccination against an Eimeria infection, are also provided.

A portable halotherapy device includes a housing, a grinding chamber with a grinding blade that breaks apart dry granular salt into salt particles small enough for halotherapy, an air duct routing air to the chamber, a fluid conduit, and a high-speed exhaust fan. Ambient air flows through the air ducts into the grinding chamber to produce a first air current. Air is diverted from the first air current upward, in a second air current, through the fluid conduit and the fan. The first air current helps move dry granular salt around and against the grinding chamber, breaking it into small salt particles. The second air current is arranged relative to the first air current such that small salt particles, but not larger pieces, are carried as salt aerosol upward through the fluid conduit and fan for distribution to the environment, thereby facilitating a halotherapy session.

An electronic smoking article includes an aerosol generator and a mouth end insert. The mouth end insert includes a mechanical aerosol converter surface having the capacity to improve characteristics of aerosol produced by the aerosol generator, including sensory attributes.

Methods are provided for acutely treating migraine headache with or without aura. The methods comprise administering to a subject with migraine headache an effective dose of a liquid pharmaceutical composition comprising dihydroergotamine (DHE) or a salt thereof, wherein the dose is administered by an intranasal delivery device that provides, following intranasal administration, (a) a mean peak plasma DHE concentration (C.sub.max) of at least 750 pg/ml, (b) with a mean time to C.sub.max (T.sub.max) of DHE of less than 45 minutes, and (c) a mean plasma AUC.sub.0-inf of DHE of at least 2500 pg*hr/ml. Also provided are kits for acutely treating migraine with or without aura in which a liquid pharmaceutical composition comprising DHE or DHE salt is contained within a sealed vial that is attachable to a precision intranasal olfactory delivery device packaged therewith.

A device for generating a condensation aerosol includes (a) vaporization chamber having an upstream first inlet and a downstream outlet; (b) a heater element in the vaporization chamber between the upstream first inlet and the downstream outlet; (c) an airflow path in fluid communication with the vaporization chamber, wherein the airflow path comprises a second inlet configured to permit a substantially laminar flow of air into the airflow path, wherein the second inlet is downstream of the heater element; and (d) the device having components or apparatus on or in the device for changing air flow in the vaporization chamber. Changing the air flow in the vaporization chamber may be used to change the particle size of a condensation aerosol produced in the vaporization chamber, and/or to change the amount of visible vapor emitted from the device.

A supplemental oxygen delivery system is described in which Aerosol is delivered into a housing 10, 20, which sits in the circuit from the supplemental oxygen supply and optional humidifier. The supplemental oxygen passes through this chamber 10, 20 in which the aerosol is located, and collects the aerosol transporting it to a patient via a nasal cannula 3 or a face mask 4. An aerosol generator 9 is mounted to the housing 10, 20 and delivers aerosol into an oxygen stream 13 flowing between an inlet 14 and an outlet 15 of the housing 10. The housing 10 also has a removable plug 16 in the base 17 thereof for draining any liquid that accumulates in the housing 10. There is no disruption of oxygen delivery to patients using nasal cannulas who currently have to use a separate face-mask when receiving nebulized medication.

Nasal medication or drug delivery devices and methods for delivering adjustable or variable metered volumetric doses of medication or drugs to a nasal passageway of a user or patient. Relative movement between portions of a reservoir establish a set volume of medication for delivery. The delivery device may include a nosepiece for fitting into the nostril of the user or patient, a medication or drug reservoir or dosing chamber, and an external reservoir adapter for providing the medication from an external reservoir.

An aerosol generator for an aerosol dispenser is presented where, the aerosol generator has a housing having an inlet part comprising a liquid inlet configured to guide a liquid jet (L) into the housing and an air inlet configured to guide an air flow into the housing. The housing further having an outlet part having an aerosol outlet configured to guide an aerosol (C) of liquid mixed with air out of the housing. The air inlet is configured such that at least part of the air flow entering the housing through the air inlet is obstructed at a distance from the liquid jet (L) entering the housing through the liquid inlet, thereby creating a source of turbulence in the housing to interact with droplets of the liquid jet (L) to prevent coalescence of the droplets.

A method for forming a changeable mist of an aromatherapy machine and the aromatherapy machine are provided. A mist storage cavity with an upward opening is disposed on the aromatherapy machine, and a mist outlet of the aromatherapy machine communicates with an inner space of the mist storage cavity. When the aromatherapy machine generates an atomized vapor in an atomization chamber, the atomization chamber is provided with an internal air pressure higher than an atmospheric pressure, so that the atomized vapor is ejected outward at a different speed state based on a different internal air pressure, so as to form a different mist retention state. In a first configuration solution, the internal air pressure is controlled to be slightly higher than an external atmospheric pressure, so that the atomized vapor floats out in a slow surge manner, and that the atomized vapor is accumulated as a haze in the inner space.