A dry powder inhaler includes a powder storage element configured to hold a powdered medicament and an inlet channel receives, powdered medicament from the powder storage element that is entrained in an airflow. The inlet channel has a first diameter and defines an opening. The inhaler includes a dispersion chamber that receives the airflow and the powdered medicament from the opening. The dispersion chamber has a second diameter. The inhaler includes an actuator housed within the dispersion chamber. The actuator oscillates within the dispersion chamber when exposed to the airflow to deaggregate the powdered medicament entrained by the airflow passing through the dispersion chamber. A ratio between the first diameter and the second diameter is between about 0.40 and 0.60 such that an audible sound is produced as the actuator oscillates. The inhaler includes an outlet channel through which the airflow and powdered medicament exit the inhaler.

Exemplary dry powder inhaler devices may include a housing body having a medicine capsule recess therein, a pair of air inlets each fluidically connecting to the recess, and an outlet body coupled to the housing body. Each inlet may have a width no greater than 1.17 mm. The outlet body may have a channel fluidically connecting the recess to an opening and configured to allow a user to draw air through the opening, thereby allowing an airstream to be drawn through the air inlets, into the housing body recess where it causes the capsule to spin and eject its contents into the airstream, and through the outlet body channel and opening to deliver the substance into the user's lungs. Dry powder respirable drug blend formulations, methods of manufacturing the formulations and drug/device combinations are also provided.

A device for delivering a predetermined amount of at least one substance to a body orifice of a subject includes a) a container for containing said at least one substance; b) a delivery end for placement in proximity to the orifice, the delivery end being in fluid communication with the container; c) a valve mechanically connectable to said container, characterized by at least two configurations: (i) an ACTIVE CONFIGURATION in which said valve enables delivery of predetermined amount of said substance from said container to said body orifice via said delivery end; and, (ii) an INACTIVE CONFIGURATION, in which said valve prevents delivery of said predetermined amount of said substance from said container to said body orifice; d) a trigger mechanism adapted to reconfigure said valve from said INACTIVE CONFIGURATION to said ACTIVE CONFIGURATION, and vice versa; and e) a fluid tight chamber.

An inhaler article (150) includes a body extending along a longitudinal axis from a mouthpiece end (154) to a distal end (156), a capsule cavity (155) defined within the body and a capsule disposed within the capsule cavity. The capsule cavity is bounded downstream by a filter element and bounded upstream and distally by a deformable element (158) the deformable element deforms to expose an open distal end and allow the inhaler article to receive swirling or rotational inhalation airflow during consumption.

A dry powder inhaler for a capsule containing dry powder, the inhaler comprising a housing having a capsule receptacle, two actuator buttons arranged on opposing sides of the housing and two perforation needles, each needle being fixedly connected to an actuator button and movable relative to the housing towards each other from a normal position to a perforation position along an actuation direction to perforate a capsule arranged in the capsule receptacle, wherein a first end of each actuator button is connected to the housing at a lower portion of the housing and in that a second free end of each actuator button is movable into the perforation position such that the perforation needle is moved along a circular line.

An inhaler article (110) comprises a body (112) extending along a longitudinal axis (A) from a mouthpiece end (113) to a distal end (114), a capsule cavity (116) defined within the body, and a distal end element (118) disposed at the distal end and extending to the capsule cavity. The distal end element comprises an element distal end (120), an element inner end (122), a solid core portion (124), and at least two grooves (126). The solid core portion extends from the element distal end to the element inner end. The at least two grooves are helical grooves that rotate about solid core portion along the longitudinal axis from the element distal end to the element inner end. The at least two helical grooves extend along an outer surface (128) of the distal end element.

An inhaler article (150) includes a body (151) extending along a longitudinal axis of the inhaler article from a mouthpiece end (154) to a distal end (156), a capsule cavity (155) and a capsule (160) retained within the capsule cavity. The capsule cavity is defined within the body and bounded downstream by a filter element (157) and bounded upstream by a tubular element (153) defining a central passage (152) in fluid communication with the capsule cavity. The central passage forms an air inlet aperture extending along the longitudinal axis of the inhaler article from the distal end of the body towards the capsule cavity, wherein the tubular element has a central passage inner diameter in a range from about 50% to about 90% of an inner diameter of the capsule cavity. The inhaler article is configured to receive a swirling inhalation airflow into the central passage.

A holder for an inhaler article includes a housing comprising a housing cavity for receiving an inhaler article a sleeve configured to retain an inhaler article within the housing cavity. The sleeve includes a sleeve cavity and is movable within the housing cavity along a longitudinal axis of the housing. The sleeve includes a first open end and a second opposing end. The first open end is configured to receive an inhaler article and the second opposing end of the sleeve is configured to allow air to enter the sleeve cavity. The second opposing end of the sleeve is configured to induce a swirl on the air entering the sleeve cavity.

The present invention provides a particulate delivery device with an automatic activation mechanism that pierces or cuts a composition capsule when a cap is removed. The cap cannot be replaced once the device is activated for use. The device allows for gas flow through the device from a gas inlet to a gas outlet through a composition receptacle and dispersion chamber to deliver particulate to the airway of a subject.

The present invention relates to an aerosol-generating device (1) for generating an aerosol by dispersing an aerosol-forming powder (31) into an airflow. The device comprises a device housing (2) which comprises an airflow passage therethrough and which is configured to receive a capsule (30) that contains the aerosol-forming powder to be discharged into the airflow passage. The device further comprises a magnetic actuator (40) which is configured to generate a movement of the capsule when being received in the device housing for de-agglomerating the aerosol-forming powder within the capsule. The invention further relates to an aerosol-generating system comprising an aerosol-generating device according to the invention and an aerosol-forming powder containing capsule for use with the aerosol-generating device.