Hyperbaric oxygen therapy (HBOT) settings of gas mixture and pressure are established based on electroencephalography (EEG) readings from a human within a hyperbaric chamber. Specifically, brainwave readings are affected by the HBOT process, which are used to improve the medical benefits achieved through the HBOT therapy regime, especially for treatments of cognitive disorders and neurological conditions detectable via EEG. In embodiments, HBOT settings are altered until a treated human is placed in a healing state, where cognition is enhanced. This healing state is quantitively definable through analysis of Alpha, Beta, Delta, and Theta EEG readings taken while in chamber and while outside the chamber. Once settings are determined to achieve a healing state of positive cognition, HBOT sessions can be conducted at pressure and gas mixture settings to ensure the healing state is achieved for each session. Post treatment analysis can be performed to determine EEG quantifiable improvements achieved.

Apparatus for providing a mixture including nitrous oxide (N.sub.2O) to a subject are disclosed. One apparatus includes a first reservoir for storing a first gas including at least N.sub.2O and a mask connected to the first reservoir in which the mask includes a second reservoir integrated with the mask. The second reservoir is for storing a first additive and the mask is for combining the first gas and the first additive to create a mixture including at least the N.sub.2O and the first additive in the mask and introducing the mixture to the mouth and/or nose of a subject. Another apparatus includes a configuration including separate first and second reservoirs storing at least N.sub.2O and a first additive in which the first reservoir and/or the second reservoir are detachably connected to the mask.

A method for the prevention and/or treatment of post-operative cognitive dysfunction, which entails administering to a human or other mammal an effective amount of one or more compounds selected from the group consisting of N-substituted 2(1H) pyridones, N-substituted 3(1H) pyridones and pharmaceutically-acceptable salts of any one or more of the above pyridones, which are optionally further substituted at various available ring positions.

A method of neurostimulation may include delivering an electrical signal to a plurality of electrodes connected to a patient. The electrical signal may include a plurality of spaced-apart packets of electrical pulses. The method may include modulating at least one of a quantity of the plurality of electrical pulses within ones of the plurality of packets of electrical pulses, a width in time of the plurality of electrical pulses within ones of the plurality of packets of electrical pulses, an amplitude in voltage of the plurality of electrical pulses within ones of the plurality of packets of electrical pulses, a separation in time between adjacent ones of the plurality of electrical pulses within ones of the plurality of packets of electrical pulses, and a separation in time between adjacent ones of the plurality of packets of electrical pulses to modulate the electrical signal.

The present invention relates to compositions, devices and methods of delayed and sustained release of energy molecules for brain function. The composition comprises an energy molecule required for human brain function; wherein the release of the energy molecule is delayed and then sustained over a period of time. The methods comprise administering the composition subject in need thereof immediately prior to going to sleep. The present invention also relates to systems for brain stimulation during sleep and methods of use thereof. The system comprises a brain stimulation module and at least one of a brain energy source, a hypnotic source, or both. The methods involve administering to a subject a brain energy molecule, a hypnotic, or both and providing to the subject during restorative sleep a sensory stimulation.

A method of galvanic vestibular stimulation (GVS) may include delivering an electrical signal via transdermal electrical stimulation using a plurality of electrodes connected to a patient. The electrical signal may include an amplitude and a carrier frequency. The method may include modulating at least one of the amplitude and the carrier frequency based on a modulation waveform to modulate the electrical signal, the modulation waveform may include a modulation frequency that is less than the carrier frequency.

A wearable intranasal device that dispenses concentrated oils, specifically Aromatherapy and Cannabidiol or CBD, allowing each to evaporate naturally through the nasal cavity providing temporary relief of a variety of symptoms these products have been positively found to impact. The device is a single unit consisting of two barrels on both ends joined by a bridging center arch and which will hug the septum of the user ergonomically not causing any irritation to the user. Each barrel receives a cotton wick which will hold the concentrated oil(s).

A method of neurostimulation may include delivering a modulated electrical signal to a patient through galvanic vestibular stimulation (GVS) and delivering a time varying thermal waveform to the patient through caloric vestibular stimulation (CVS) simultaneous with the delivery of the modulated electrical signal through GVS.

Disclosed are methods of treating depression, mania, post-traumatic stress disorder (PTSD), and various other neurologic conditions using synaptic pathway training. Methods of synaptic pathway training include, generally, achieving a favorable treatment result by activating a synaptic pathway using a pharmacologic agent, such as treating refractory symptoms of depression with ketamine, following by potentiation of the favorable result by repeatedly stimulating the activated pathway. Stimulation of a synaptic pathway may be achieved by intrinsic means, such as performance of cognitive exercised, or extrinsic means, such as by delivery of a sensory stimulus to the patient, placing a potential voltage difference across the brain or a brain region, or by placing the brain or a brain region in a magnetic field.

A method of neurostimulation may include delivering an electrical signal to a plurality of electrodes connected to a patient. The electrical signal may include a plurality of spaced-apart packets of electrical pulses. The method may include modulating at least one of a quantity of the plurality of electrical pulses within ones of the plurality of packets of electrical pulses, a width in time of the plurality of electrical pulses within ones of the plurality of packets of electrical pulses, an amplitude in voltage of the plurality of electrical pulses within ones of the plurality of packets of electrical pulses, a separation in time between adjacent ones of the plurality of electrical pulses within ones of the plurality of packets of electrical pulses, and a separation in time between adjacent ones of the plurality of packets of electrical pulses to modulate the electrical signal.