A method may include accessing a terminal branch of an ophthalmic artery through a face of a subject. Additionally, the method may include positioning a device within the ophthalmic artery of the subject and treating at least one of a blockage, a stenosis, a lesion, plaque or other physiology in at least one of the ophthalmic artery or a junction between an internal carotid artery and the ophthalmic artery.

In some examples, a catheter may include an elongate body and a push assembly. The elongate body may include an inner liner defining an entry port into a lumen, and an outer jacket. The push assembly may an elongate member extending from a proximal portion to a distal portion, where a cross-section of the distal portion is D-shaped and tapers in a distal direction. Distal to a proximal end of the elongate body, a first portion of the elongate member may be positioned between a portion of the inner liner and a portion of the outer jacket, and proximal to the proximal end of the elongate body, a second portion of the elongate member may be positioned outside of the outer jacket and the inner liner.

An intravascular device comprises an elongated outer catheter body having a proximal catheter end, a distal catheter end, and an inner catheter lumen extending between the proximal catheter end and the distal catheter end. The intravascular device further comprises an elongated inner articulating member slidably disposed within the inner catheter lumen. The inner articulating member has a proximal member end and an articulatable distal member end. The intravascular device further comprises a control assembly mechanically coupled to the proximal catheter end and the proximal member end. The control assembly is configured for distally translating the outer catheter body over the inner articulating member, and for articulating the distal member end.

An intravascular device comprises an elongated outer catheter body having a proximal catheter end, a distal catheter end, and an inner catheter lumen extending between the proximal catheter end and the distal catheter end. The intravascular device further comprises an elongated inner articulating member slidably disposed within the inner catheter lumen. The inner articulating member has a proximal member end and an articulatable distal member end. The intravascular device further comprises a control assembly mechanically coupled to the proximal catheter end and the proximal member end. The control assembly is configured for distally translating the outer catheter body over the inner articulating member, and for articulating the distal member end.

An introducer includes a dilator received in a lumen defined by an introducer sheath and including a dilation end extending distally beyond a distal end of the introducer sheath. The introducer sheath includes a flat wire reinforcement having a hollow cylindrical shape sandwiched between an inner PTFE tube and an outer nylon tube. The outer nylon tube includes a distal segment that extends distally beyond the PTFE tube, which extends distally beyond the PTFE tube, which extends distally beyond the flat wire reinforcement. A withdrawal support wire has a distal end attached to a distal end turn of the flat wire reinforcement and extends in a proximal direction in parallel with a longitudinal axis between an outer surface of the nylon tube and an inner surface of the PTFE tube. The withdrawal support wire is configured to be in tension when the sheath is placed in tension to inhibit distal stretch separation breakage.

System for monitoring and regulating plant productivity comprising: a memory for storing instructions; a processor for executing the instructions to cause a method of monitoring and regulating plant productivity to be performed, the method comprising: receiving field data from monitoring sensors; computing, by the at least one processor executing a machine learning algorithm, a predicted value for a variable associated with the production environment condition of a crop field, the machine learning algorithm having been trained based on a training set comprising one or both of (a) the field data from the monitoring sensors, and (b) a generated feature derived from the field data; and determining, based on a threshold associated with the variable, that the predicted value for the variable indicates that an intervention in the crop field is to be initiated; and in response to the determining, causing a controllable device to vary the production environment condition.

An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall. A method can involve injection/infusion of the ablative fluid over an extended time period of at least 10 seconds or with two injections at two different penetration depths to reduce or eliminate patient pain during ablation.

System for monitoring and regulating plant productivity comprising: a memory for storing instructions; a processor for executing the instructions to cause a method of monitoring and regulating plant productivity to be performed, the method comprising: receiving field data from monitoring sensors; computing, by the at least one processor executing a machine learning algorithm, a predicted value for a variable associated with the production environment condition of a crop field, the machine learning algorithm having been trained based on a training set comprising one or both of (a) the field data from the monitoring sensors, and (b) a generated feature derived from the field data; and determining, based on a threshold associated with the variable, that the predicted value for the variable indicates that an intervention in the crop field is to be initiated; and in response to the determining, causing a controllable device to vary the production environment condition.

A method may include accessing an artery in communication with an ophthalmic artery of a subject, and advancing a microcatheter along the accessed artery so as to align a distal end of the microcatheter with an ostium of the ophthalmic artery, wherein the microcatheter includes a lumen having a guidewire positioned therein. In addition, the method includes proximally withdrawing the guidewire relative to the microcatheter so as to enable a distal portion of the microcatheter to assume a curved relaxed configuration, and cannulating the ostium with the distal portion of the microcatheter when the distal portion is in the curved relaxed configuration.

A dilation apparatus includes a handle assembly, a dilator, a guidewire, and a steering assembly. The dilator is connected to the handle assembly and is configured to transition between an unexpanded state and an expanded state. The guidewire is longitudinally fixed relative to the dilator. The steering assembly is configured to laterally deflect at least a portion of the guidewire relative to the handle assembly. The steering assembly includes an actuator coupled with the handle assembly and a pull wire extending between the actuator and guidewire. A portion of the pull wire is attached to the guidewire. The actuator is configured to move the pull wire relative to the handle assembly in order to laterally deflect the at least a portion of the guidewire.