Certain embodiments provide a cannula system with a retention mechanism comprising a cannula, a hub coupled to the cannula, wherein a distal end of the cannula is configured to be inserted into a body part up to the hub, and a retention mechanism configured to create resistance for retaining the cannula inside the body part in response to force exerted on the cannula for pulling the cannula out of the body part. The retention mechanism may include retention elements coupled to a bottom surface of the hub, and by rotating the hub in a first direction, the one or more retention elements that are parallel to a surface of the body part are configured to penetrate the body part. In other embodiments, the retention mechanism may include halfpipe elements that pivot on fulcrum points to hold or release the hub and cannula from the body part.

An example catheter assembly includes a first catheter body portion defining a first lumen and a plurality of sidewall openings open to the lumen and configured to at least one of introduce fluid into a patient or remove fluid from the patient. The catheter assembly further includes a second catheter body portion defining a second lumen, a first cuff proximal to a distal end of the first catheter body portion, a second cuff distal to a proximal end of the second catheter body portion, and a connector configured to mechanically connect the first and second catheter body portions between the first and second cuffs and to fluidically connect the first and second lumens. A distance between the first and second cuffs is modifiable by at least modifying one of a length of the first catheter body portion or a length of the second catheter body portion.

An indwelling pleural catheter system comprises an indwelling catheter device (2) comprising a catheter tube (7) with a fenestrated distal end (7A) configured to reside in the pleural cavity of a subject and a connection hub (10) fluidically coupled to a proximal end (7B) of the catheter tube, a skin anchoring member (3) to anchor the connection hub (10) to the skin of the subject, and optionally a detachable ambulatory suction module (4) configured for detachable attachment to the connection hub (10). The suction module (4) comprises a fluid inlet (19) configured for fluidic coupling to the catheter tube (7) through the connection hub (10) and a fluid outlet (20) configured for detachable fluidic coupling to a pleural fluid drainage system (5) to drain pleural fluid through the detachable ambulatory suction module. The detachable ambulatory suction module is configured to exert a negative pressure in the catheter tube upon detachment of the pleural fluid drainage system from the suction module. Treatment of pleural effusion using the system of the invention is described. An indwelling catheter system for draining fluid from the peritoneal cavity, and methods of treating ascites, is also described.

An indwelling pleural catheter system comprises an indwelling catheter device (2) comprising a catheter tube (7) with a fenestrated distal end (7A) configured to reside in the pleural cavity of a subject and a connection hub (10) fluidically coupled to a proximal end (7B) of the catheter tube, a skin anchoring member (3) to anchor the connection hub (10) to the skin of the subject, and optionally a detachable ambulatory suction module (4) configured for detachable attachment to the connection hub (10). The suction module (4) comprises a fluid inlet (19) configured for fluidic coupling to the catheter tube (7) through the connection hub (10) and a fluid outlet (20) configured for detachable fluidic coupling to a pleural fluid drainage system (5) to drain pleural fluid through the detachable ambulatory suction module. The detachable ambulatory suction module is configured to exert a negative pressure in the catheter tube upon detachment of the pleural fluid drainage system from the suction module. Treatment of pleural effusion using the system of the invention is described. An indwelling catheter system for draining fluid from the peritoneal cavity, and methods of treating ascites, is also described.

Provided herein is a bridging device including, in some embodiments, a piece of tubing including a securement loop, a first connector at a first end of the piece of tubing, and a second connector at a second end of the piece of tubing. Also provided herein is a male external catheter (“MEC”) kit including, in some embodiments, an MEC; a drainage bag for the MEC; and the bridging device for fluidly connecting the MEC to the drainage bag. The securement loop of the piece of tubing is configured for securing the bridging device in a securement device optionally included in the MEC kit. The first connector is configured to connect to the MEC. The second connector is configured to connect to the drainage bag for the MEC. Methods for making and using the foregoing bridging device and MEC kit are also provided.

Provided herein is a bridging device including, in some embodiments, a piece of tubing including a securement loop, a first connector at a first end of the piece of tubing, and a second connector at a second end of the piece of tubing. Also provided herein is a male external catheter (“MEC”) kit including, in some embodiments, an MEC; a drainage bag for the MEC; and the bridging device for fluidly connecting the MEC to the drainage bag. The securement loop of the piece of tubing is configured for securing the bridging device in a securement device optionally included in the MEC kit. The first connector is configured to connect to the MEC. The second connector is configured to connect to the drainage bag for the MEC. Methods for making and using the foregoing bridging device and MEC kit are also provided.

Medical fluid extension set systems are disclosed that can include a tubing anchor coupled to tubing and a fluid coupling device, and can be anchored to a patient to resist unintended separation of the tubing anchor or a catheter coupled to the tubing, from a patient, and to permit separation or disconnection of a fluid pathway between the tubing and another device coupled to thereto upon exceeding a pulling force on the fluid coupling device, and where disconnection includes separation of first and second valve assemblies such that a fluid pathway of the first and second valve assemblies is obstructed upon disconnection of the fluid coupling device.

Medical fluid extension set systems are disclosed that can include a tubing anchor coupled to tubing and a fluid coupling device, and can be anchored to a patient to resist unintended separation of the tubing anchor or a catheter coupled to the tubing, from a patient, and to permit separation or disconnection of a fluid pathway between the tubing and another device coupled to thereto upon exceeding a pulling force on the fluid coupling device, and where disconnection includes separation of first and second valve assemblies such that a fluid pathway of the first and second valve assemblies is obstructed upon disconnection of the fluid coupling device.

Provided herein is a catheter assembly, including a catheter adapter having a proximal end, a distal end, and a lumen extending along a first longitudinal axis therebetween, a catheter extending from the distal end of the catheter adapter, a dressing comprising a proximal end, a distal end, and first and second sides extending therebetween, the dressing defining a second longitudinal axis and configured to cover at least a portion of the catheter adapter at a site of penetration into a patient's vasculature, the dressing further comprising an upper surface and a lower surface, the lower surface configured to contact skin of a patient, and a tourniquet configured to apply a radially-inward pressure to a limb of a patient near the site of penetration, the tourniquet configured to couple with the dressing.

Provided herein is a catheter assembly, including a catheter adapter having a proximal end, a distal end, and a lumen extending along a first longitudinal axis therebetween, a catheter extending from the distal end of the catheter adapter, a dressing comprising a proximal end, a distal end, and first and second sides extending therebetween, the dressing defining a second longitudinal axis and configured to cover at least a portion of the catheter adapter at a site of penetration into a patient's vasculature, the dressing further comprising an upper surface and a lower surface, the lower surface configured to contact skin of a patient, and a tourniquet configured to apply a radially-inward pressure to a limb of a patient near the site of penetration, the tourniquet configured to couple with the dressing.