The present technology relates to a hemostasis sealing device having a device enclosure with a first seal portion for a medical device and a second seal portion for guide wire sealing. The device enclosure can be generally configured for compressive communication with a housing. The second seal portion can define a split that is in compressive communication with structural elements of the hemostasis sealing device, which can simultaneously provide sealing functionality and allow passage of relatively large-bore devices.

A catheter for radial artery access to the contralateral subclavian artery and internal mammary artery is disclosed. The catheter includes a preformed tubular hook element configured for aligning coaxially within the subclavian artery from a radial access. The tubular hook element includes a first arm connected to a second arm via a curved element, and a second arm connected, via a second curved element, to an elongated tubular body. Each curved element has an angle between approximately 90-130 degrees. The catheter can receive a second catheter and guide it to further advance the subclavian artery. The second catheter then extends past distal end of the catheter and advances into the internal mammary arteries for selective angiography and intervention. The two-catheter system allows angiography and intervention of the entire right and left upper extremities to be performed depending on the access from the left or right radial artery, respectively.

A catheter for radial artery access to the contralateral subclavian artery and internal mammary artery is disclosed. The catheter includes a preformed tubular hook element configured for aligning coaxially within the subclavian artery from a radial access. The tubular hook element includes a first arm connected to a second arm via a curved element, and a second arm connected, via a second curved element, to an elongated tubular body. Each curved element has an angle between approximately 90-130 degrees. The catheter can receive a second catheter and guide it to further advance the subclavian artery. The second catheter then extends past distal end of the catheter and advances into the internal mammary arteries for selective angiography and intervention. The two-catheter system allows angiography and intervention of the entire right and left upper extremities to be performed depending on the access from the left or right radial artery, respectively.

Three groups of guidewire embodiments are described with particularly suitable structures for navigating circuitous vessels, especially blood vessels of the brain. Some of the guidewires have a hyperbolic taper that provides desired flexibility. In some embodiments, an integrated guide structure provides for extension in the blood vessel of a corewire to provide for extended reach of the guidewire. In further embodiments, the guidewire has a flexible tip that can be guided directly by the flow in the vessel.

Three groups of guidewire embodiments are described with particularly suitable structures for navigating circuitous vessels, especially blood vessels of the brain. Some of the guidewires have a hyperbolic taper that provides desired flexibility. In some embodiments, an integrated guide structure provides for extension in the blood vessel of a corewire to provide for extended reach of the guidewire. In further embodiments, the guidewire has a flexible tip that can be guided directly by the flow in the vessel.

Apparatuses, systems, and methods for controlling the sampling of tissue using a guidewire. In an illustrative embodiment, an apparatus includes a handle, a flexible dual lumen catheter couplable to the handle, and a guidewire guide disposed at a distal end of the flexible dual lumen catheter.

An elongated catheter assembly defines a catheter lumen configured to receive the distal guidewire section of the guidewire, and also defines an axial portal and a radial portal. A guidewire deflector is mounted to the elongated catheter assembly. The guidewire deflector is configured to selectively deflect urged axial movement of the distal guidewire section of the guidewire away from the axial portal and radially toward the radial portal.

An elongated catheter assembly defines a catheter lumen configured to receive the distal guidewire section of the guidewire, and also defines an axial portal and a radial portal. A guidewire deflector is mounted to the elongated catheter assembly. The guidewire deflector is configured to selectively deflect urged axial movement of the distal guidewire section of the guidewire away from the axial portal and radially toward the radial portal.

An endoscopic treatment tool, includes an elongated member having a distal end and a proximal end; a braid disposed between the distal end and the proximal end of the elongated member; a distal indicator disposed on the elongated member between a distal end and a proximal end of the braid, the distal indicator extending along a longitudinal axis of the elongated member; a proximal indicator disposed between the distal end and the proximal end of the braid on the elongated member at a more proximal side of the elongated member than the distal indicator, the proximal indicator extending along the longitudinal axis; and a pre-curved shape portion formed in a curved shape, wherein each of the distal indicator and the proximal indicator has a width less than half of an outer circumferential surface of the elongated member in a circumferential direction of the elongated member, respectively.

An endoscopic treatment tool, includes an elongated member having a distal end and a proximal end; a braid disposed between the distal end and the proximal end of the elongated member; a distal indicator disposed on the elongated member between a distal end and a proximal end of the braid, the distal indicator extending along a longitudinal axis of the elongated member; a proximal indicator disposed between the distal end and the proximal end of the braid on the elongated member at a more proximal side of the elongated member than the distal indicator, the proximal indicator extending along the longitudinal axis; and a pre-curved shape portion formed in a curved shape, wherein each of the distal indicator and the proximal indicator has a width less than half of an outer circumferential surface of the elongated member in a circumferential direction of the elongated member, respectively.