This application discloses methods and tools for the treatment of chronic fatigue syndrome (CFS) and fibromyalgia and the use of retinal nerve fiber layer thinning as a biomarker for the treatment.

A control system and method for automatically adjusting the height of an external ventricular drain from a patient. The height of a pole supporting the bag into which the fluid is drained can be varied, increased or decreased, as driven by a motor. A drip chamber and collection bag that receive the fluid from the patient are attached to the height variable pole. An external fluid pressure tube is coupled to the patient at one end and to a pressure sensor at the other. The pressure sensor is coupled to the height variable pole. The system includes a feedback loop that adjusts the height of the external ventricular drain (EVD) to match the height of the patient's head. As the patient's head moves up or down, the variable height pole moves up and down a corresponding distance to maintain the patient's intracranial or intraspinal pressure, and therefore the cerebrospinal fluid (CSF) drainage rate, at a preset value.

A method for treatment of a brain and/or spinal cord includes inserting a flexible catheter into a cerebrospinal fluid space, the flexible catheter including two lumens adapted to allow a fluid to circulate therein in a closed loop within the flexible catheter and the flexible catheter being adapted to be connected to a device for cooling and circulating the fluid. The cerebrospinal fluid in the cerebrospinal fluid space is cooled with the flexible catheter to enable selective central nervous system cooling. The functional status of the brain and/or spinal cord is monitored, and the treatment of the brain and/or spinal cord is modified to adjust for any change in the functional status of the brain and/or spinal cord.

In one embodiment, the present application discloses, in part, a balloon catheter assembly comprising: a) a balloon catheter comprising a proximal end, a distal end; and b) a connecting line comprising a proximal end and a distal end, wherein the proximal end comprises a first terminal magnetic connector for forming a water tight connection with the magnetic click connector on the port panel.

Cerebrospinal fluid (CSF) and other fluid amelioration systems completely or partially implantable within a mammalian subject and associated methods include a substrate and an agent for amelioration of a toxic biomolecule present in the CSF or fluid, wherein the agent is disposed on or within the substrate.

A shunt including an implantable housing having a proximal end and a distal end. A pressure sensitive valve is contained within the housing at a position between the proximal end and the distal end, and the pressure sensitive valve is capable of controlling a flow of fluid between the fluid inlet port and the fluid outlet port. The shunt further including a sensor assembly fluidly coupled to the pressure sensitive valve, wherein the sensor assembly is mechanically actuated and capable of detecting the flow of fluid through the pressure sensitive valve. A condition of the shunt can be detected by detecting a flow of fluid through the shunt and generating a signal indicative of a period of fluid flow through the implantable shunt based on the detecting. The signal can be output to an external device capable of determining, from the signal, whether the shunt is malfunctioning.

The disclosure relates generally to an extended use systems and devices for management of bladder function for people with urinary dysfunction. The system includes a catheter and a valve that can control fluid flow. The catheter can be placed inside the bladder using devices that facilitate insertion and extraction. The placement of the catheter can be done by a trained individual such as a patient, as well as a clinician, a nurse, or a caretaker. Once placed inside the bladder, the catheter can be fully-internal, meaning no portion of the catheter is visible from outside of the patient's body.

An innovative medical device that permits rapid, minimally invasive restoration of blood flow across a vascular blockage. A system allowing for lysis or removal of said blockage. Said device creates a temporary bypass using longitudinal structure configured for insertion into the blood vessel and adapted to deliver a side hole to a target area. The side hole defines a distal first segment and a proximal second segment with a lumen to allow blood flow therethrough to the distal end hole. In an alternate embodiment, a slidable outer sheath can cover the side hole to permit reversal of blood flow from the distal end hole to a proximal end hole located outside a patient's body by means of an aspiration controller. Alternate embodiments include an optional anchoring balloon, a macerating stent or wires, perforations for fluid delivery, and an backflow valve.

A method for treatment of a brain and/or spinal cord includes inserting a flexible catheter into a cerebrospinal fluid space, the flexible catheter including two lumens adapted to allow a fluid to circulate therein in a closed loop within the flexible catheter and the flexible catheter being adapted to be connected to a device for cooling and circulating the fluid. The cerebrospinal fluid in the cerebrospinal fluid space is cooled with the flexible catheter to enable selective central nervous system cooling. The functional status of the brain and/or spinal cord is monitored, and the treatment of the brain and/or spinal cord is modified to adjust for any change in the functional status of the brain and/or spinal cord.

In one embodiment, a system for evacuating subdural hematomas includes an inlet configured to be placed in fluid communication with a subdural space, an irrigation reservoir in fluid communication with the inlet and configured to supply irrigation fluid to the inlet and the subdural space, an outlet separate from the inlet and also configured to be placed in fluid communication with the subdural space, and a pump in fluid communication with the outlet and configured to create negative pressure within the subdural space and evacuate fluid from the subdural space.