An implant includes a cannula. The cannula defines an axial drainage bore and a plurality of radial openings providing a path of fluid communication between an exterior of the cannula and the axial drainage bore to drain fluid. The implant also includes a first sensor positioned at least partially in the cannula. The first sensor is configured to measure a biomarker in the fluid. The implant also includes a second sensor positioned at least partially in the cannula. The second sensor is configured to measure a pressure of the fluid. The implant also includes a third sensor positioned at least partially in the cannula. The third sensor is configured to measure a temperature of the fluid.

Systems, catheters, and methods for accessing and treating along the central nervous system are disclosed. An example method may manage inflammation of the patient to treat a condition of the patient by processing values related to one or more physiological parameters of a patent, identifying when an inflammation condition of the patient has reached a treatment condition based on the processed values, and automatically providing an indication that the inflammation condition has reached the treatment condition. An example indication may include actuation of a treatment protocol. The example method may be performed with an inflammation management system.

A filtering device for removing particles from a fluid of a patient is provided. The filtering device being implantable in the patient's body and comprising a cassette comprising a revolving member, said revolving member having at least two segments each holding a respective filter. The device further comprises a tube forming a fluid passageway through one of the filters in said cassette, wherein the cassette is adapted to, upon revolution of the revolving cylinder, change the filter positioned in the fluid passageway from a first one of said filters to a second one of said filters, thereby allowing particles present on the first filter to be moved away from the fluid passageway, while at the same time changing the filter positioned in the fluid passageway.

Provided are body fluid management systems for patient care that include, in operable combination, a control system assembly comprising a fluid flow detection and control subassembly, a user data interface, a patient interface assembly comprising a wearable pressure sensor subassembly having a pressure sensor in the path of said body fluid for attaching directly to a patient proximate to an anatomical marker and an orientation sensor to monitor and/or control the pressure and/or flowrate of a body fluid such as cerebrospinal fluid, blood, or urine.

A device for use in pressure sensing has a housing enclosing a chamber and having at least one port that communicates with the chamber. A pressure sensor receives fluid pressure from the chamber. The chamber has a compliance that exhibits a marked change in volumetric stiffness repeatably at a fixed pressure.

A blood clot removal method for removing blood clots from the vascular system of a patient, the blood clot removal method carried out on an implantable device in the patient's body and comprising: allowing a blood flow through a passageway between a first side wall and a second side wall, filtering blood clots with a filter provided in the blood flow passageway, and cleaning the filter with a cleaning device, wherein the cleaning device is moved from the first side wall towards the second side wall to move blood clots away from the blood flow passageway.

An externally programmable shunt valve assembly that includes a magnetic rotor that is operable in response to an externally applied magnetic field and configured to increase or decrease the working pressure of the shunt valve assembly in finite increments.

Implantable shunt devices and methods for draining cerebrospinal fluid from a patient's subarachnoid space include a shunt having opposed first and second ends, the second end being constructed to penetrate a wall of a sigmoid, transverse, straight, or sagittal sinus of the patient, a one-way valve, a hollow passageway extending between the second end and the one-way valve such that cerebrospinal fluid can be drained through the second end and out through the valve, and a mechanism coupled to the shunt and configured to anchor the shunt at a desired location proximal to the subarachnoid space.

Disclosed is a system that includes pressure sensors to assist in monitoring pressure at a selected location. Pressure sensors may be applied to or incorporated into catheters and/or shunts positioned within a patient. A monitoring system may then receive signals from the pressure sensors to monitor pressure at the location over time.

An apparatus for minimally-invasive, including non-invasive, prevention and/or treatment of hydrocephalus and method for use of the same are disclosed. In one embodiment of the apparatus, a housing is sized for superjacent contact with a skull having a fontanel. Within the housing, a compartment includes a pressure applicator, such as a fluid-filled bladder, under the control of a pressure regulator. The pressure applicator is configured to selectively apply an external pressure to the fontanel. The compartment includes a pressure sensor configured to measure intracranial pulse pressure of the fontanel. Further, in one embodiment, the apparatus can cause pulse pressure modulation by adjusting the intracranial pulse pressure via the pressure applicator. This enables a non-invasive measurement of the pulse pressure and modulation thereof in infants, for example.