Discloses is a method of manufacturing a micro-needle. The method includes a step of preparing a medicinal solution, a step of forming a plurality of tips with the medicinal solution, and a step of forming a cavity in each of the tips. In accordance with such a configuration, a micro-needle in which cavities are formed is provided, whereby it is possible to administer a fixed amount of medicine in a short time.

Disclosed are composite microneedles arrays including microneedles and a film overlaying the microneedles. The film includes a plurality of nano-sized structures fabricated thereon. Devices may be utilized for interacting with a component of the dermal connective tissue. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. Devices may be beneficially utilized for delivery of an agent to a cell or tissue. Devices may be utilized to directly or indirectly alter cell behavior through the interaction of a fabricated nanotopography with the plasma membrane of a cell and/or with an extracellular matrix component.

The present invention concerns delivery of agents through the skin. Methods for delivering agents such as bioactive agents are contemplated by the present invention. Specifically, methods for the targeted delivery of agents to one or more areas of the epidermis and thereby, to one or more cancer tumors are described.

A multi-type microneedle is proposed. The multi-type microneedle includes: a substrate part; a plurality of needle holes provided in the substrate part; a plurality of needle parts provided at a predetermined distance from each other along a circumferential direction of each of the needle holes on an area of the substrate part partitioning each of the needle holes; and a patch in contact with a user's skin while in contact with one surface of the substrate part, wherein since the needle parts is provided in a certain pattern around one needle hole by further having a drug injection part or a drug storage part capable of additionally supplying a drug, the needle parts are inserted into a predetermined area of the skin so that the drug to be delivered into the body may be rapidly diffused or permeated subcutaneously, and also an amount of the drug delivered is controlled.

A derma roller apparatus has a head, which has a cylindrical member and a plurality of needles situated around the cylindrical member. The width of the cylindrical member may be in a range of four to twelve inches. Furthermore, each of the plurality of needles may have a length of at least five tenths millimeters. In addition, the derma roller apparatus has a swivel, a connector, and a handle. The connector connects to a first endpoint of the head and a second endpoint of the head. Furthermore, the handle is operably attached to the connector via the swivel. The handle is configured to move along a yaw axis with respect to a collinear plane that is collinear with the head and the handle. Finally, the first endpoint and the second endpoint of the head are transverse to the collinear plane. As an alternative, the handle may be telescopic.

A high-density microneedle of the present disclosure includes: a sheet portion attached to skin; a substrate portion arranged on the sheet portion; and a plurality of insertion pieces arranged on the substrate portion, wherein the substrate portion is arranged on the sheet portion while having a plurality of layers formed therein.

A microneedle includes a base having a support surface, and a projection that protrudes from the support surface, the projection having a through hole that penetrates the projection in an extending direction of the projection. The projection includes a flow path expansion section which is configured to expand a communication path that communicates between an inner space of the through hole and a space surrounding the projection in response to an increase in pressure of a fluid flowing in the through hole.

Methods for mass production of new microfluidic devices are described. The microfluidic devices may include an array of micro-needles with open channels in fluid communication with multiple reservoirs located within a substrate that supports the micro-needles. The micro-needles are configured so as to sufficiently penetrate the skin in order to collect or sample bodily fluids and transfer the fluids to the reservoirs. The micro-needles may also deliver medicaments into or below the skin.

Disclosed are medical devices that incorporate siRNA. In addition to one or more siRNA constructs, devices include nanostructures fabricated on a surface to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. Microneedles may be incorporated on devices. The pattern including nanostructures may be formed on the surface of the microneedles.

The present invention concerns delivery of agents to the skin. Methods for delivering agents such as bioactive agents are contemplated by the present invention. Specifically, methods for delivering an agent to one or more areas of the epidermis and, thereby, to the lymphatic system are described.