The disclosure provides for an isovolumetric pump system for the removal of a thrombus and a method of use thereof. The isovolumetric pump system includes at least one inflow container connected to an output of the treatment region, at least one outflow container connected to an input of the treatment region, and a drawbar connecting the inflow container and the outflow container. As the drawbar is drawn back, the same quantity of fluid is drawn from the treatment region into the inflow container and injected into the treatment region from the outflow container.

A medical device is adapted for use in assisting with mechanical thrombectomy. The medical device may include a housing that is adapted to be held within a user's hand and a pump that is secured within the housing. A fluid inlet is adapted to receive fluid that is pulled towards the pump and is fluidly coupled with the pump. A fluid outlet is adapted to expel fluid away from the pump and is fluidly coupled with the pump. As the pump is operated by the user, fluid is alternatively pulled into the fluid inlet and expelled through the fluid outlet. In some cases, the fluid may be blood or other bodily fluids.

A suction device configured to simultaneously draw in fluid and expel fluid. The suction device may comprise a barrel defining a cavity and extending from a first end to a second end. A first fluid inlet may be adjacent the first end of the barrel and a second fluid inlet adjacent the second end of the barrel and a first fluid outlet may be adjacent the first end of the barrel and a second fluid outlet adjacent the second end of the barrel. A plunger may be slideably disposed within the cavity of the barrel with a handle assembly operably coupled thereto. A actuation of the handle assembly may be configured to move the plunger within the cavity between the first end and the second end of the barrel.

A suction device configured to simultaneously draw in fluid and expel fluid. The suction device may comprise a barrel defining a cavity and extending from a first end to a second end. A first fluid inlet may be adjacent the first end of the barrel and a second fluid inlet adjacent the second end of the barrel and a first fluid outlet may be adjacent the first end of the barrel and a second fluid outlet adjacent the second end of the barrel. A plunger may be slideably disposed within the cavity of the barrel with a handle assembly operably coupled thereto. A actuation of the handle assembly may be configured to move the plunger within the cavity between the first end and the second end of the barrel.

Compositions and methods are provided for metabolically degrading ADMA. In one embodiment a device is provided for reducing a patients ADMA levels in their blood wherein the device comprises a biologically active dimethylarginine dimethylaminohydrolase (DDAH) polypeptide covalently linked to a solid support. In one embodiment a method for reducing ADMA levels in a patients blood comprises the step of contacting the patients blood or a blood fraction with an immobilized biologically active DDAH polypeptide, wherein contact of the patients blood with said DDAH polypeptide results in degradation of ADMA present in the patients blood.

Compositions and methods are provided for metabolically degrading ADMA. In one embodiment a device is provided for reducing a patients ADMA levels in their blood wherein the device comprises a biologically active dimethylarginine dimethylaminohydrolase (DDAH) polypeptide covalently linked to a solid support. In one embodiment a method for reducing ADMA levels in a patients blood comprises the step of contacting the patients blood or a blood fraction with an immobilized biologically active DDAH polypeptide, wherein contact of the patients blood with said DDAH polypeptide results in degradation of ADMA present in the patients blood.

A device for extracting arterial and pulmonary embolisms is described herein. The device comprises a suction catheter and a return catheter attached to a reservoir. The reservoir comprises two filters that filter out any unwanted material from the blood. The device may be controlled by a console with a pedal. Blood containing unwanted material is suctioned out of a patient, is filtered in the reservoir, and is returned to the patient. The device prevents blood loss from the patient by returning the blood back to the patient after it is filtered. Furthermore, the filtration system is designed to also remove air from the blood as it is suctioned from the patient.

A pump cassette is disclosed. The pump cassette includes a housing having at least one fluid inlet line and at least one fluid outlet line. The cassette also includes at least one reciprocating pressure displacement membrane pump within the housing. The pressure pump pumps a fluid from the fluid inlet line to the fluid outlet line. A hollow spike is also included on the housing as well as at least one metering pump. The metering pump is fluidly connected to the hollow spike on the housing and to a metering pump fluid line. The metering pump fluid line is fluidly connected to the fluid outlet line.

Described is a cannula (110, O1 to O3, I1 to I3) comprising: —a lumen portion (LP) that extends axially between a proximal part of the cannula (110, O1 to O3, I1 to I3) and at least one distal part of the cannula (110, O1 to O3, I1 to I3), and —an expandable arrangement (114) at the at least one distal part of the lumen portion, wherein the expandable arrangement (114) is adapted to have an expanded state and a non-expanded state, wherein in the expanded state a volume defined by the expandable arrangement (114) is greater than the volume defined by the expandable arrangement (114) in the non-expanded state.

An exemplary apparatus, can include, for example, a circulating tumor cell (CTC) treatment arrangement, a pump arrangement configured to circulate a fluid through the CTC treatment arrangement, and an electric field generator electrically connected to the CTC treatment arrangement, and configured to apply an electric field to the fluid circulating through the CTC treatment arrangement. The pump arrangement can be a peristaltic pump, which can be configured to continuously circulate the fluid through the CTC treatment arrangement. According to another exemplary embodiment of the present disclosure, method, system and computer-accessible medium can be provided for killing at least one circulating tumor cell (CTC). Using such exemplary embodiment, blood can be pumped from a body of a patient to an electroporation chamber inside of a CTC treatment arrangement. An electric field can be applied to the blood located in the electroporation chamber in order to kill the CTC. The electric field-applied blood can be pumped back into the body.