Systems and methods of an electronic drug delivery system for use in a treatment program (e.g., a smoking cessation program). The delivery system can include a mobile platform and a hand-held inhalation delivery device having a controller circuit coupled to a power source, sensors, aerosolizer drivers, and a rescue button, and a pod removably coupled to the delivery device. The delivery system generates an aerosol mixture from substances in the pod in accordance with the treatment program, and delivers the aerosol mixture for inhalation by a user. The controller circuit individually and dynamically controls the aerosolizer drivers to generate signals that drive a plurality of thermal, or non-thermal, aerosolizers of the pod to generate individually tailored aerosol mixtures from multiple substances in the aerosolizer pod. The generated aerosol mixtures can have various percentages of the substances, and have different aerosol droplet sizes during different portions of the treatment program.

The present invention provides new devices, systems, and methods for delivering enriched oxygen to recipients (e.g., chronically ill patients, such as COPD patients). One aspect is a more efficient portable oxygen concentrator that is configured to deliver an enriched oxygen airflow having a significantly lower overall oxygen concentration and greater overall volume administered as compared to currently marketed or known portable oxygen concentrators. Administering the lower oxygen concentration at higher volumes allows for the present portable oxygen concentrators to deliver an equivalent number of moles of oxygen as administered by traditional portable concentrators while increasing the efficiency of the system and the ability of the system to maintain the therapeutic level of oxygen concentration for a longer period.

A system for detecting manual ventilation and selectively delivering a high flow of oxygen. The system comprises a source of compressed oxygen coupled to a first lumen of a nasal cannula, with an oxygen flow control valve coupled to a processor to control the flow of oxygen to the nasal cannula. A second lumen of the nasal cannula is in connection with a pressure sensor and the pressure sensor in connection with the processor. The processor may receive the pressure values and be programmed to determine when manual ventilation has occurred, and send a signal to the oxygen flow control valve to send a high flow of oxygen in response to manual ventilation.

An oxygen delivery apparatus wearable by user includes a frame including nose pads connected to a bridge portion, an oxygen inlet defined by one of the nose pads, an oxygen inlet defined by the frame, and a hollow channel contained by the frame. The oxygen inlet and oxygen outlet are in fluid communication via the hollow channel. The frame can be formed as a monolithic structure using additive manufacturing. A nasal prong can be connected to the oxygen outlet such that a prong outlet of the prong is in fluid communication with the hollow channel. The prong outlet is positioned within a nostril of the user during use of the apparatus. A method of fabricating the frame includes obtaining measurement information for at least one of a head feature or facial characteristic of the user and generating a digital model of the oxygen delivery apparatus using the measurement information.

A pressure safety device is used with a bag valve mask (BVM) for preventing over-pressurization. The BVM includes a bag assembly having a bag connector for detachably mating to a mask connector on a patient mask. The pressure safety device has a housing with a bag port, a mask fitting, and a flow path from the bag port to the mask fitting. The bag port detachably connects to the bag connector on the BVM, and the mask fitting detachably connects to the mask connector on the BVM. The pressure safety device includes an automatic flow reduction valve located on the flow path in the housing and impedes flow when pressure on a bag connector side of the valve exceeds a maximum threshold value.

A system that enables remote adjustment of oxygen flow from an oxygen source includes a gas source device fluidly coupled to a gas source, a remote delivery device with an outlet for providing gas to a user and an inlet fluidly coupled to an outlet of the gas source device, wherein the gas source device has a control system. The control system determines a current control setting of the remote delivery device based on pneumatic feedback from the remote delivery device and modifies a pressure of gas flowing from the gas source device to the remote delivery device based on the current control setting of the remote delivery device, so that a target flow volume of supply gas associated with the current control setting is delivered to the inlet.

A system that enables remote adjustment of oxygen flow from an oxygen source includes a gas source device fluidly coupled to a gas source, a remote delivery device with an outlet for providing gas to a user and an inlet fluidly coupled to an outlet of the gas source device, wherein the gas source device has a control system. The control system determines a current control setting of the remote delivery device based on pneumatic feedback from the remote delivery device and modifies a pressure of gas flowing from the gas source device to the remote delivery device based on the current control setting of the remote delivery device, so that a target flow volume of supply gas associated with the current control setting is delivered to the inlet.

A respiratory assistance apparatus includes a conduit connecting a flow generator and an outlet. The conduit includes a venture formation. The apparatus further includes an oxygen inlet in fluid communication or selective fluid communication with an oxygen outlet. The oxygen outlet is directed into the conduit and toward a mouth of the venture formation. The flow generator provides a flow path for air to enter the conduit when the flow generator is not operating.

System for gas treatment of cellular implants. The system enhances the viability and function of cellular implants, particularly those with high cellular density, for use in human or veterinary medicine. The system utilizes a miniaturized electrochemical gas generator subsystem that continuously supplies oxygen and/or hydrogen to cells within an implantable and immunoisolated cell containment subsystem to facilitate cell viability and function at high cellular density while minimizing overall implant size. The cell containment subsystem is equipped with features to allow gas delivery through porous tubing or gas-only permeable internal gas compartments within the implantable cell containment subsystem. Furthermore, the gas generator subsystem includes components that allow access to water for electrolysis while implanted, thereby promoting long-term implantability of the gas generator subsystem. An application of the system is a pancreatic islet (or pancreatic islet analogue) implant for treatment of Type 1 diabetes (T1D) that would be considered a bio-artificial pancreas.

A system and method for video assisted percutaneous needle cricothyrotomy and tracheostomy to assist physicians in quickly intubating patients suffering from respiratory distress when oral or nasal intubation is not possible or contraindicated. The system and method includes a display monitor, a percutaneous needle assembly including a connection hub having a syringe port for removably attaching a syringe, a needle port for attaching a hollow needle, and a stylet port in communication with the needle port for receiving a fiber optic stylet that extends through the hollow needle. The fiber optic stylet includes one or more illuminators, and a camera for capturing and transmitting anatomical images for display on the display monitor to visually assist physicians in locating a patient's trachea lumen. The fiber optic stylet is positioned within the trachea lumen, and used as a guide wire to insert a dilator and cannula for ventilating the patient.