The present invention pertains to inter alia methods for purifying extracellular vesicles including exposing a sample comprising at least one extracellular vesicle to ultrafiltration; and exposing the sample following the ultrafiltration in step (i) to size exclusion liquid chromatography.

A pump includes a pump housing including an inlet for the fluid on a low-pressure side, an outlet for the fluid on a high-pressure side, a circumferential wall facing faces axially away from the delivery chamber and on which the outlet emerges; a spring structure arranged on the outer end face of the end wall; a delivery member movable within the delivery chamber for delivering the fluid from the low-pressure side to the high-pressure side; and a securing device for axial securing the pump housing. The securing device includes a female holding element having an axially extending cavity and a male holding element in a joining engagement, exposable to an axial tensile load, with the female holding element in the cavity. The spring structure and/or the end wall is/are held on the pump housing by one of the holding elements by the joining engagement.

A vane cell pump, including: a rotor and a plurality of vanes rotatable with the rotor, wherein the rotor includes a sub-vane chamber for each vane, and each vane forms a shifting wall of the sub-vane chamber assigned to it; first and second end-facing walls adjoining the rotor on end-facing sides and which, in order to control pressure to the sub-vane chamber, include sub-vane cavities which extend in the circumferential direction of the rotor and include control edges as viewed in the circumferential direction; wherein the control edge of the sub-vane cavity of the first end-facing wall, and the control edge of the sub-vane cavity of the second end-facing wall which is similar to it, are arranged angularly offset about the rotational axis as the apex with respect to each other.

A multi-stage vacuum pump comprising a stator defining multiple pumping chambers is discussed. The stator comprises a plurality of transfer channels for providing a fluid passage from an outlet port of one of the plurality of pumping chambers to an inlet port of a subsequent pumping chamber. Some of the transfer channels comprise two side channel sections on opposing sides of the stator. One of the transfer channels comprises a single side channel section on one side of the stator. The vacuum pump further comprises a gas ballast inlet channel arranged on an other side of the stator to the one side of the stator.

A multi-stage vacuum pump comprising a stator defining multiple pumping chambers is discussed. The stator comprises a plurality of transfer channels for providing a fluid passage from an outlet port of one of the plurality of pumping chambers to an inlet port of a subsequent pumping chamber. Some of the transfer channels comprise two side channel sections on opposing sides of the stator. One of the transfer channels comprises a single side channel section on one side of the stator. The vacuum pump further comprises a gas ballast inlet channel arranged on an other side of the stator to the one side of the stator.

Disclosed are a main bearing seat for a scroll compressor, and a scroll compressor. The main bearing seat comprises substantially ring-shaped thrust parts for supporting a compressing mechanism of the scroll compressor, and a main part body provided with a bearing to support a driving shaft of the scroll compressor, wherein multiple suspension parts extending in a radial direction of the scroll compressor are provided in the thrust parts, and the suspension parts are arranged in an axial direction of the scroll compressor. The main bearing seat can adjust the stiffness of the thrust parts to better achieve stiffness matching and deformation coordination with a bottom face of a movable vortex, thereby increasing the effective contact area on a contact side of a thrust surface to achieve more uniform contact stress distribution and reduce the wear, and providing an appropriate gap on a non-contact side to facilitate lubrication

A vane pump includes: a rotor; vanes freely slidably received in the rotor; a cam ring having a cam face with which the vanes come into sliding contact; a side member having a sliding contact surface with which side surfaces of the rotor and the vanes come into sliding contact; pump chambers; and a discharge port configured to guide working fluid discharged from the pump chambers. The side member has a guide surface that is provided on an end portion side of the opening portion, the guide surface being configured to push the end portions of the vanes upward and guide them toward the sliding contact surface of the side member as the rotor is rotated in the reverse rotation direction.

A rotational engine system comprises a rotational engine and a propulsion system. The rotational engine includes an outer ring enclosure, an inner ring component, and a drive gear. The inner ring component includes a piston and a drive gear engagement portion. The piston is configured to travel within the outer ring enclosure along a circumference of the outer ring enclosure. The drive gear engagement portion is configured to rotate as the piston travels along the circumference of the circular shape of the outer ring enclosure. The drive gear is coupled to the drive gear engagement portion of the inner ring component such that rotation of the drive gear engagement portion rotationally drives the drive gear. The propulsion system is configured to deliver propulsive energy to propel the piston along the circumference of the outer ring enclosure.

A rotational engine system comprises a rotational engine and a propulsion system. The rotational engine includes an outer ring enclosure, an inner ring component, and a drive gear. The inner ring component includes a piston and a drive gear engagement portion. The piston is configured to travel within the outer ring enclosure along a circumference of the outer ring enclosure. The drive gear engagement portion is configured to rotate as the piston travels along the circumference of the circular shape of the outer ring enclosure. The drive gear is coupled to the drive gear engagement portion of the inner ring component such that rotation of the drive gear engagement portion rotationally drives the drive gear. The propulsion system is configured to deliver propulsive energy to propel the piston along the circumference of the outer ring enclosure.

The present invention pertains to inter alia methods for purifying extracellular vesicles including exposing a sample comprising at least one extracellular vesicle to ultrafiltration; and exposing the sample following the ultrafiltration in step (i) to size exclusion liquid chromatography.