A conduit with a collapsible portion, and a nasal interface for providing a flow of gases to a user, is described. The interface comprises a manifold and at least one nasal prong or an outlet extending from the manifold to be received by a user's nare. A side member extends from each side of the manifold, each side member comprising a collapsible portion comprising a lumen. In an open configuration the lumen remains open and in a closed configuration the collapsible portion is pinched or flattened to occlude or substantially occlude the lumen. At least one of the side members is a conduit for a flow of gases from an inlet of the patient interface to the manifold.

The present invention provides a device for delivering a predetermined amount of at least one substance to a body orifice of a subject; comprising: a. a container for containing said at least one substance; b. a delivery end for placement in proximity to said orifice, said delivery end being in fluid communication with said container; c. a valve mechanically connectable to said container, characterized by at least two configurations: (i) an ACTIVE CONFIGURATION in which said valve enables delivery of predetermined amount of said substance from said container to said body orifice via said delivery end; and, (ii) an INACTIVE CONFIGURATION, in which said valve prevents delivery of said predetermined amount of said substance from said container to said body orifice; d. a trigger mechanism adapted to reconfigure said valve from said INACTIVE CONFIGURATION to said ACTIVE CONFIGURATION, and vice versa; e. a fluid tight chamber.

This invention provides ventilators that provide superior air-oxygen mixing and gas delivery. The ventilators that supply a gas mixture to the lungs of a subject. The gas mixture comprises a first gas (e.g. oxygen) and a second gas (e.g. ambient air). The ventilators comprise a first gas inlet, a second gas inlet, flow modulator of the first gas, a flow modulator of the second gas, a junction configured to mix the first gas and the second gas, a patient interface configured to deliver the gas mixture to a subject, a pressure sensor, a plurality of flow sensors comprising at least a first flow sensor and a second flow sensor, and at least one controller configured for obtaining data from the pressure sensor and flow sensors and controlling the flow modulators to provide a gas mixture having a target pressure and a target oxygen content.

Methods and devices for delivering one or more substances within at least one body cavity are provided. The device includes at least one nosepiece including at least one capsule having a volume V.sub.sub of the substances; at least one base in communication with the nosepiece, the base including at least one chamber configured to confine pressurized fluid at volume V.sub.PF and pressure P.sub.PF; and at least one hollow puncturing member. The hollow puncturing member includes at least one end in fluid communication with the nosepiece and a second end in fluid communication with the base. The first and second ends are fluidly interconnected by a hollow tube. The fluid inlet port of the capsule is configured in terms of size and shape to interface in a sealable manner with the one end of the at least one puncturing member.

Disclosed herein are portable gas delivery systems and therapeutic methods of use. More specifically, the portable gas delivery systems herein include a regulator having an inhalation device, such as a mouthpiece, and is configured to operably couple with removable sealed gas cartridges that comprise a therapeutic gas mixture of either one or more noble gases or nitrous oxide.

A method for controlling gas composition in a surgical cavity during an endoscopic surgical procedure includes monitoring for a plurality of gas species in a gas flow from a surgical cavity of a patient. The method includes measuring the plurality of gas species in the gas flow from the surgical cavity and determining if the gas species measured in the gas flow from the surgical cavity are each present and/or within a respective desired range. The method includes adding gas into the surgical cavity if one or more gas species in the plurality of gas species is outside of the respective desired range so as to bring a composition of gas species in the surgical cavity within the respective desired range.

Described here are closed-circuit breathing devices and methods for their use. In general, the closed-circuit breathing device is configured to achieve a steady-state equilibrium, whereby therapeutic gas is introduced into the breathing circuit in small, controlled volumes until a steady state concentration of the therapeutic gas is reached. During this time, the closed-circuit breathing device is operated in a true closed circuit, such that the therapeutic gas is not lost to the atmosphere. Safety measures are built into the closed-circuit breathing device so that a hypoxic mixture is not delivered to the subject. The therapeutic gas may be xenon.

Described here are closed-circuit breathing devices and methods for their use. In general, the closed-circuit breathing device is configured to achieve a steady-state equilibrium, whereby therapeutic gas is introduced into the breathing circuit in small, controlled volumes until a steady state concentration of the therapeutic gas is reached. During this time, the closed-circuit breathing device is operated in a true closed circuit, such that the therapeutic gas is not lost to the atmosphere. Safety measures are built into the closed-circuit breathing device so that a hypoxic mixture is not delivered to the subject. The therapeutic gas may be xenon.

A method for the extraction of xenon gas bound to a filter material using supercritical CO.sub.2 to form a mixture in which both CO.sub.2 and xenon are in a supercritical state.

A method for the extraction of xenon gas bound to a filter material using supercritical CO.sub.2 to form a mixture in which both CO.sub.2 and xenon are in a supercritical state.