A ventilator is configured to supply a gas mixture to the lungs of a subject. The gas mixture comprises a first gas (e.g. oxygen) and a second gas (e.g. ambient air). The ventilator comprise a first gas inlet, a second gas inlet, flow modulator of the first gas, a flow modulator of the second gas, a junction configured to mix the first gas and the second gas, a patient interface configured to deliver the gas mixture to a subject, a pressure sensor, a plurality of flow sensors comprising at least a first flow sensor and a second flow sensor, and at least one controller configured for obtaining data from the pressure sensor and flow sensors and controlling the flow modulators to provide a gas mixture having a target pressure and a target oxygen content.

The present invention relates generally to the fields of treating psychiatric disorders, in particular, anxiety disorders including post-traumatic stress disorder (PTSD) in subjects, e.g., human subjects, by administering a xenon and/or argon containing composition. Treatments can also employ psychotherapy in combination with administration of xenon and/or argon, alone or in combination with additional psychotherapeutic medications to treat the anxiety disorder and reduce a symptom of the anxiety disorder in the subject.

The present invention relates generally to the fields of treating psychiatric disorders, in particular, anxiety disorders including post-traumatic stress disorder (PTSD) in subjects, e.g., human subjects, by administering a xenon and/or argon containing composition. Treatments can also employ psychotherapy in combination with administration of xenon and/or argon, alone or in combination with additional psychotherapeutic medications to treat the anxiety disorder and reduce a symptom of the anxiety disorder in the subject.

A system, method, and device for preserving blood and its components is described. The system and method generally include a device having a body defining a chamber, the chamber being configured to receive at least one bag containing blood or its components, the at least one bag being permeable to gas, for example, xenon. A cover is hermetically sealable to the body. An inlet is in fluid communication with the chamber. A pressure indicator is configured to indicate pressure in the chamber, the pressure indicator including a conduit containing a liquid. A portion of the conduit is transparent such that the liquid is visible. A source of pressurized gas, such as xenon, is provided to provide the pressurized gas to the chamber.

An intubation device is provided. An intubation device comprises a movable guide configured to guide an insertion of an endotracheal tube into a trachea of a patient, the guide having a guide extension and a guide tip; an external trachea identifier source external to the trachea and disposed on the patient during an intubation, wherein the trachea identifier source generates and transmits a signal; at least one trachea condition sensor disposed on the guide tip to detect the signal generated by the trachea identifier source; and a guide control device operatively coupled to the guide, the guide control device configured to move the guide into the trachea in response to the detected signal.

A method and a platelet concentrate preservation device for platelet concentrate storage. A method includes at least partially saturating platelet concentrate xenon, and storing the platelet concentrate at less than 15 C in a generally horizontal position. A device can be used to store blood, blood products, or combinations thereof that may or may not be under pressure. The device includes a chamber having a cavity. The chamber includes first and second chamber parts that form the cavity when releasably connected together. The cavity is designed to receive at least one bag that contains the blood, blood products, or combinations thereof. The device also includes a high-strength casing and includes a chamber cavity. The high-strength casing includes first and second casing parts that form the chamber cavity when releasably connected together. The chamber cavity is designed to receive the chamber.

A system for safely delivering an efficient amount of oxygen to essential organs, during cardiopulmonary resuscitation (CPR) is described; a respective method and an endotracheal device for delivering a semi-spontaneous positive-pressure ventilation are further described; the system comprises; at least one limb compression device, a positive-pressure ventilation system, an endotracheal tube, a cardiac stimulation device, an intra-tracheal pressure sensor, a synchronizer; the method comprises; compressing at least one limb device and occluding a blood flow into the limb, delivering a mixture of gases, providing an endotracheal tube, conferring a deployed configuration, conferring a withheld configuration, performing a cardiac stimulation device, determining a pressure, synchronizing a timing; the endotracheal device comprises; an elongated tube, a sealing cuff assuming a deployed configuration and withheld

A system, method, and device for preserving blood and its components is described. The system and method generally include a device having a body defining a chamber, the chamber being configured to receive at least one bag containing blood or its components, the at least one bag being permeable to gas, for example, xenon. A cover is hermetically sealable to the body. An inlet is in fluid communication with the chamber. A pressure indicator is configured to indicate pressure in the chamber, the pressure indicator including a conduit containing a liquid. A portion of the conduit is transparent such that the liquid is visible. A source of pressurized gas, such as xenon, is provided to provide the pressurized gas to the chamber.

Devices and methods for delivering oxygen and other therapeutic gases to a target, such as a tissue, a tissue-engineered construct, and a wound, in a controlled and sustained manner are disclosed

A device for delivering a predetermined volume of a substance within at least one body cavity of a subject includes a predefined volume for containing the predetermined volume of the at least one substance. The device also includes a delivery end for placement in proximity to the body cavity where the delivery end includes at least one orifice of diameter D. The device further includes a valve mechanically connectable to the container, the valve having at least two configurations: (i) an active configuration in which the valve enables delivery of predetermined volume V.sub.sub [ml] of the substance and, (ii) an inactive configuration, in which the valve prevents delivery of the predetermined volume V.sub.sub [ml] of the substance from the container to the body cavity. The device also includes a fluid tight chamber configured to contain a predetermined volume V.sub.gas [ml] of pressurized gas at a predetermined pressure, P.sub.gas [barg].