The present invention provides a cerebrospinal fluid shunt system that monitors the intracranial pressures over a portion of a monitoring cycle to calculate short intervals of drainage for every monitoring cycle necessary to produce the desired pressure correction. The system operates to significantly reduce the time during which draining occurs allowing tissue surrounding the catheter to rebound from the catheter holes returning to its normal position for a sufficient amount of time to recover its normal shape.

The present disclosure generally relates to systems and methods of use for draining cerebrospinal fluid (CSF) from a brain or a spinal canal in a subject, for example, to treat hydrocephalus or other conditions. In some embodiments, the disclosure relates to a device comprising a flow controller positioned within a conduit that allows CSF to flow through the conduit from a first end to a second end. This may allow the CSF to drain, for example, from an intradural space (such as a thecal sac) into, for example, a paraspinal space, paraspinal vein or other venous space, or peritoneal cavity. A variety of methods may be used to hold or anchor the device in place, for example, an expansion apparatus. In some embodiments, the device can be implanted percutaneously at a location along or within a subject's spinal column, thus reducing the need for surgery, general anesthesia, and hospitalizations.

Apparatus and associated methods relate to smart shunt systems. In an illustrative example, a cerebrospinal fluid (CSF) shunt system includes an interface module and conduit(s) configured to provide selective fluid communication between a brain ventricle(s) and at least one reservoir. The interface module may be operably coupled to one or more control module(s). The control module(s) may, for example, be operably coupled to one or more actuator(s) and/or sensor(s) (e.g., in the interface module(s), external to the interface module(s)). The control module(s) may, for example, selectively operate one or more of the actuator(s) as a function of input received from one or more of the sensors based on one or more predetermined control profile(s). Various embodiments may advantageously dynamically (e.g., automatically) control physiological attributes (e.g., CSF attributes).

A treatment device of a cerebrovascular disorder capable of reliably controlling an oxygen concentration of a brain tissue so as not to be excessively high while efficiently supplying oxygen to the brain is provided. The treatment device of a cerebrovascular disorder includes: a main body including an injection unit that is to be inserted into a living body and injects a fluid; oxygen concentration measurement units disposed at two or more locations in the living body; and a flow rate adjustment unit that adjusts a flow rate of the fluid to be injected by the injection unit, in which the flow rate adjustment unit adjusts the flow rate of the fluid to be injected by the injection unit according to oxygen concentrations at two or more locations in the living body measured by the oxygen concentration measurement units.

Systems, catheters, and methods for accessing and treating along the central nervous system are disclosed. An example method may manage inflammation of the patient to treat a condition of the patient by processing values related to one or more physiological parameters of a patent, identifying when an inflammation condition of the patient has reached a treatment condition based on the processed values, and automatically providing an indication that the inflammation condition has reached the treatment condition. An example indication may include actuation of a treatment protocol. The example method may be performed with an inflammation management system.

Provided are body fluid management systems for patient care that include, in operable combination, a control system assembly comprising a fluid flow detection and control subassembly, a user data interface, a patient interface assembly comprising a wearable pressure sensor subassembly having a pressure sensor in the path of said body fluid for attaching directly to a patient proximate to an anatomical marker and an orientation sensor to monitor and/or control the pressure and/or flowrate of a body fluid such as cerebrospinal fluid, blood, or urine.

The disclosed systems and methods are configurable central nervous system (CNS) delivery solutions for therapeutics, such as genetic medicines. The systems and methods first infuse a therapeutic bolus within intrathecal space and subsequently infuse a flush fluid to move the therapeutic bolus rostrally toward a target area and achieve a desired spread in the spine and/or brain. The second location can be at a location caudal to the delivery location of the therapeutic bolus.

The disclosed systems and methods are configurable central nervous system (CNS) delivery solutions for therapeutics, such as genetic medicines. The systems and methods first infuse a therapeutic bolus within intrathecal space and subsequently infuse a flush fluid to move the therapeutic bolus rostrally toward a target area and achieve a desired spread in the spine and/or brain. The second location can be at a location caudal to the delivery location of the therapeutic bolus.

A system and related method are provided for draining cerebrospinal fluid from a bodily cavity of a patient, such as a ventricle in the brain in one application. The system includes a reservoir which may be a collapsible container configured for fluidic connection to a shunt located in the bodily cavity. The collapsible container may be an elastically deformable bladder in one embodiment. A pump is fluidly connected to the collapsible container and draws cerebrospinal fluid therefrom. A programmable controller directs the pump to repeatedly activate and deactivate at a predetermined time interval. A plurality of sensors may be provided which are communicably coupled to the controller for monitoring pump motor current draw, tension in the resilient body of the container, pressure, and orientation of the patient. The controller is configurable to deactivate the pump when abnormal operating conditions are detected by the sensors.

An implantable intracranial pulse pressure modulator for treating hydrocephalus in patients of all ages is disclosed as well as a system and method for use of the same. In one embodiment of the implantable intracranial pulse pressure modulator, two one-way valves are interposed in parallel, opposing orientations between a vestibule and a chamber. One of the one-way valves, in response to systole, provides fluid communication from the vestibule to the chamber such that a small aliquot of cerebrospinal fluid (CSF) is displaced from a cerebral ventricle into a ventricular catheter, thereby reducing intraventricular systolic pressure. The other one-way valve, in response to diastole, provides fluid communication from the chamber to the vestibule such that the same volume of CSF is reintroduced into a cerebral ventricle, thereby increasing intraventricular diastolic pressure. Together, both processes work synergistically to reduce intraventricular pulse pressure in order to treat hydrocephalus.