An aerosol generating system for generating a respirable dry powder aerosol from a liquid solution or liquid suspension, having: a liquid aerosol generating nozzle having a nozzle input end designed to receive the liquid solution or liquid suspension, and having a nozzle heliox supply designed to receive nozzle heliox, the liquid aerosol generating nozzle further having a nozzle output end for outputting a liquid aerosol suspended in the nozzle heliox; and a cylindrical evaporation chamber having a cylindrical evaporation chamber input end that is connected to the nozzle output end and connected to a dilution heliox supply for receiving both the liquid aerosol suspended in the nozzle heliox and for receiving the dilution heliox, and the cylindrical evaporation chamber having a cylindrical evaporation chamber output end outputting a first intermediate dry powder aerosol at a first intermediate dry powder aerosol volume flow of a specific concentration.

Provided is a blister pack for a dry powder inhaler configured to deliver a first powder medicament and a second powder medicament different from the first powder medicament. The first and second powder medicaments are contained within blister pockets defined in a strip. A series of blister pockets is defined in the strip, which series extends linearly along the length of the strip. The first and second powder medicaments are contained in blister pockets of the series. Alternatively or additionally, each of the blister pockets is elongated such as to have a largest dimension parallel with the length of the strip. These measures, either individually or in combination, enable minimizing of the width of the strip in spite of the strip accommodating both the first and second powder medicaments.

An inhaler article (150) includes a body extending along a longitudinal axis from a mouthpiece end (154) to a distal end (156), a capsule cavity (155) defined within the body and a capsule disposed within the capsule cavity. The capsule cavity is bounded downstream by a filter element and bounded upstream and distally by a deformable element (158) the deformable element deforms to expose an open distal end and allow the inhaler article to receive swirling or rotational inhalation airflow during consumption.

A solid particulate formulation comprising soluble ferric pyrophosphate and a sachet comprising the solid particulate formulation of soluble ferric pyrophosphate for adding to a dialysis solution are provided. Improved methods of administering soluble ferric pyrophosphate comprising the solid particulate formulations and kits comprising the solid particulate formulation and a dialysis concentrate formulation are also disclosed.

A dry powder inhaler for a capsule containing dry powder, the inhaler comprising a housing having a capsule receptacle, two actuator buttons arranged on opposing sides of the housing and two perforation needles, each needle being fixedly connected to an actuator button and movable relative to the housing towards each other from a normal position to a perforation position along an actuation direction to perforate a capsule arranged in the capsule receptacle, wherein a first end of each actuator button is connected to the housing at a lower portion of the housing and in that a second free end of each actuator button is movable into the perforation position such that the perforation needle is moved along a circular line.

An inhaler article (110) comprises a body (112) extending along a longitudinal axis (A) from a mouthpiece end (113) to a distal end (114), a capsule cavity (116) defined within the body, and a distal end element (118) disposed at the distal end and extending to the capsule cavity. The distal end element comprises an element distal end (120), an element inner end (122), a solid core portion (124), and at least two grooves (126). The solid core portion extends from the element distal end to the element inner end. The at least two grooves are helical grooves that rotate about solid core portion along the longitudinal axis from the element distal end to the element inner end. The at least two helical grooves extend along an outer surface (128) of the distal end element.

An inhaler article (110) comprises a body (112) extending along a longitudinal axis (A) from a mouthpiece end (113) to a distal end (114), a capsule cavity (116) defined within the body, and a distal end element (118) disposed at the distal end and extending to the capsule cavity. The distal end element comprises an element distal end (120), an element inner end (122), a solid core portion (124), and at least two grooves (126). The solid core portion extends from the element distal end to the element inner end. The at least two grooves are helical grooves that rotate about solid core portion along the longitudinal axis from the element distal end to the element inner end. The at least two helical grooves extend along an outer surface (128) of the distal end element.

An inhaler article (150) includes a body (151) extending along a longitudinal axis of the inhaler article from a mouthpiece end (154) to a distal end (156), a capsule cavity (155) and a capsule (160) retained within the capsule cavity. The capsule cavity is defined within the body and bounded downstream by a filter element (157) and bounded upstream by a tubular element (153) defining a central passage (152) in fluid communication with the capsule cavity. The central passage forms an air inlet aperture extending along the longitudinal axis of the inhaler article from the distal end of the body towards the capsule cavity, wherein the tubular element has a central passage inner diameter in a range from about 50% to about 90% of an inner diameter of the capsule cavity. The inhaler article is configured to receive a swirling inhalation airflow into the central passage.

An inhaler article (150) includes a body (151) extending along a longitudinal axis of the inhaler article from a mouthpiece end (154) to a distal end (156), a capsule cavity (155) and a capsule (160) retained within the capsule cavity. The capsule cavity is defined within the body and bounded downstream by a filter element (157) and bounded upstream by a tubular element (153) defining a central passage (152) in fluid communication with the capsule cavity. The central passage forms an air inlet aperture extending along the longitudinal axis of the inhaler article from the distal end of the body towards the capsule cavity, wherein the tubular element has a central passage inner diameter in a range from about 50% to about 90% of an inner diameter of the capsule cavity. The inhaler article is configured to receive a swirling inhalation airflow into the central passage.

An inhaler article includes a body extending along a longitudinal axis from a mouthpiece end to a distal end, a capsule cavity defined within the body and a tubular element extending from the distal end towards the capsule cavity. The tubular element defines a central passage extending from the distal end towards the capsule cavity. The tubular element includes at least one air inlet allowing air to enter into the central passage. The at least one air inlet extends in a direction that is tangential to the central passage.