An article for use with an apparatus for heating aerosol generating agent to volatilize at least one component of the aerosol generating agent, the article including a support layer having a first surface, wherein at least a portion of the first surface is rough and an aerosol generating agent on the portion of the first surface that is rough.

Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.

The designs and methods disclosed herein are for a clot retrieval catheter that can have a proximal elongate body with a large bore lumen and a distal tip expandable to a diameter larger than the outer sheath through which it is delivered. The distal tip can have a flexible metallic support frame to provide radial scaffolding and the ability for further flexible expansion when ingesting a clot. The support frame can be designed so that the expanding movement is focused in a portion of the circumference though a plurality of deformable cells that can collapse to be almost flat and parallel to the longitudinal axis for deliverability, but expand to a very steep angle for good resistance to collapse under aspiration. The designs can be sufficiently flexible to navigate tortuous anatomy but recover to maintain the inner diameter of the lumen when displaced in a vessel.

A pharmaceutical product including a housing that defines a cavity, wherein the cavity stores a pharmaceutical material, and wherein the housing comprises a material configured to dissolve based on contact with a fluid, an ingestible device to encode information in a current signature, wherein the ingestible device is positioned within the housing, and a protective material that encompasses the ingestible device. The ingestible device may be attached to a flexible component, wherein the flexible component is configured to releasably secure the ingestible device within the housing.

Disclosed is a modular system for a drug delivery device with electronic, comprising a mechanical module that comprises a distal end and a proximal end, and a mechanism that is configured to set and/or to deliver a dose of the drug out of the distal end (D) of the mechanical module, an electronic module that comprises a detector unit, and an electronic unit that is operatively coupled to the detector unit,
wherein the electronic module is removably mechanically coupled or coupleable to the mechanical module in a proximal end region of the mechanical module.

A personal respiratory isolation system (PRIS) provides a personal, negative pressure environment for a patient or user that reduces contamination and spread of pathogens exhaled by the patient into the environment. The PRIS includes an enclosure to receive the patient's head (such as a hood and a drape) and a negative pressure source which draws ambient air into the interior of the enclosure and draws air within the enclosure's interior (including the exhalations of the patient, including any contaminants and/or pathogens) out of the enclosure via a fluid port into a container for biohazard processing or disposal. The PRIS may allow positive air pressure therapeutic treatments to be delivered to the patient within the negative pressure environment, and the PRIS may maintain a constant pressure within the interior of the enclosure. The PRIS may include a transparent, hinged face shield for ease of patient observation and/or access.

An intermittent urinary catheterisation assembly (1) for self-catheterisation comprises an intermittent urinary catheter (5) comprising a catheter tube. The catheter further comprises a conduit (4) extending longitudinally within the catheter tube and defining at least part of a flow path from a distal insertion end of the catheter to a proximal outlet end thereof, a measuring system for determining at least one fluid parameter in the flow path. The measuring system comprises at least one sensor element (35) configured to determine the at least one fluid parameter in the conduit and/or in a space in communication with the conduit and a signal processing device. In one aspect, the signal processing device comprises is detachable secured in relation to the connecting portion of the intermittent urinary catheter. In another aspect, the measuring system is securely connected to or integrated with the non-insertable portion of the catheter tube.

A capsule article (100) includes a polymeric body (110) extending along a longitudinal axis from a first end to a second end and defining a capsule cavity (105) containing powder, and a metal foil (120) and a sealant layer (130) covering an outer surface of the polymeric body. A method of forming a hermetic capsule includes the steps of wrapping a capsule, with a metal foil; and enclosing the capsule with a sealant layer to form a hermetic barrier enclosing the capsule.

To provide a guide wire including a core shaft having an elongated outer shape, and a coating film on an outer surface of the core shaft, the coating film containing a resin. The coating film includes a marker portion containing a pigment on an outer surface of the coating film and a resin portion not containing the pigment. On the outer surface of the coating film, the marker portion and the resin portion are alternately visible in a stretching direction. Of the coating film, a thickness of a portion where the marker portion is visible on the outer surface and a thickness of a portion where the resin portion is visible on the outer surface are substantially the same, or the thickness of the portion where the marker portion is visible is smaller than the thickness of the portion where the resin portion is visible.

A patient interface comprising a cushion having a nasal plenum chamber, an oral plenum chamber, and a passage formed between the nasal and oral plenum chambers. The passage is configured to allow airflow to pass between the nasal and oral plenum chambers. The cushion also includes a valve including valve body and an adjustment structure that is positioned between the nasal chamber and the oral chamber and is movable relative to the valve body. The adjustment structure is movable between an open position that is configured to allow airflow between the nasal plenum chamber and the oral plenum chamber, and a closed position configured to limit airflow between the nasal plenum chamber and the oral plenum chamber. The adjustment structure is configured to allow airflow through a nasal vent in the closed position and is configured to limit airflow through the nasal vent in the open position.