INGESTIBLE DEVICE WITH PHARMACEUTICAL PRODUCT

Abstract

A pharmaceutical product including a housing that defines a cavity, wherein the cavity stores a pharmaceutical material, and wherein the housing comprises a material configured to dissolve based on contact with a fluid, an ingestible device to encode information in a current signature, wherein the ingestible device is positioned within the housing, and a protective material that encompasses the ingestible device. The ingestible device may be attached to a flexible component, wherein the flexible component is configured to releasably secure the ingestible device within the housing.

Claims

1.-20. (canceled)

21. A pharmaceutical product, comprising: a capsule having an upper end and a lower end, wherein the upper and lower ends are brought together to form a housing that defines a cavity and wherein the cavity is filled with a drug, the capsule configured to disintegrate when in contact with a surrounding fluid; and an ingestible device associated with the capsule to encode information in a current signature, wherein the ingestible device is placed within the housing, wherein the ingestible device comprises electronic components that are surrounded by a protective layer, the protective layer comprising a geometry configured to be embedded into a distal end of either the upper end or the lower end of the capsule, and wherein the protective layer is configured to begin to disintegrate after the capsule has begun to disintegrate and has exposed the content of the capsule to the surrounding fluids.

22. The product of claim 21, wherein the ingestible device further comprises dissolvable components that are surrounded by the protective layer.

23. The product of claim 21, wherein the protective layer is configured to prevent at least one of the capsule or the drug from interacting with the electronic components of the ingestible device.

24. The product of claim 21, wherein the protective layer is configured to delay exposure of the electronic components to the surrounding fluid.

25. The product of claim 24, wherein the delayed exposure delays activation of the ingestible device.

26. The product of claim 21, wherein the protective layer is embedded into the distal end of either the upper end or the lower end of the capsule using the force of friction.

27. The product of claim 21, wherein the ingestible device comprises a partial power source comprising first and second electrodes.

28. The product of claim 27, wherein the partial power source is configured to power the electronic components after the first and second electrodes are exposed to a conductive fluid.

29. The product of claim 21, wherein the protective layer is laminated around the electronic components.

30. The product of claim 21, wherein the protective layer is held into the distal end of either the upper end or the lower end of the capsule using a mechanical attachment.

31. The product of claim 21, wherein the ingestible device is configured to encode the information in the current signature after it is powered on.

32. The product of claim 21, wherein the ingestible device is configured to be powered on after it comes in contact with a conductive fluid.

Description

DESCRIPTION OF THE DRAWINGS

[0032] FIG. 1 shows a capsule with a laminated device inside the capsule.

[0033] FIG. 2A shows a capsule with a table inside the capsule and the tablet includes a covered device.

[0034] FIG. 2B shows a capsule with a table inside the capsule and the tablet includes a device.

[0035] FIG. 3 shows a capsule with a covered device inside one portion of the capsule.

[0036] FIG. 4A shows an example of a device that can be used in the capsule of FIG. 3.

[0037] FIG. 4B shows another example of a device that can be used in a capsule end for FIG. 3 with a specific designed capsule end to mechanically hold the device in place.

[0038] FIG. 5 shows a device with a cover secured onto a tablet and the tablet placed inside a capsule.

[0039] FIG. 6 shows the process of laminating or covering the device.

[0040] FIG. 7 shows a closer view of the assembly pieces of FIG. 6.

[0041] FIG. 8 shows a process of inserting a device within a capsule end in accordance with one aspect of the present invention.

[0042] FIG. 9 shows an advanced stage of the process of FIG. 8.

[0043] FIG. 10 shows a perspective view of a transfer tray.

[0044] FIG. 11 shows an initial stage of the process of inserting a device within a capsule end in accordance with one aspect of the present invention.

[0045] FIG. 12 shows the device of FIG. 11 within the transfer tray of FIG. 10.

[0046] FIG. 13 shows an advanced stage of the process of FIG. 11 in accordance with one aspect of the present invention.

[0047] FIG. 14 shows an advanced stage of the process of FIG. 13 in accordance with one aspect of the present invention.

DETAILED DESCRIPTION

[0048] The present invention discloses multiple approaches to protecting a device from the harmful effects of a capsule and the content of the capsule when the device is placed within the capsule. The present invention also discloses multiple approaches to securing the device within the capsule that contains the product. The scope of the present invention is not limited by the type of product within the capsule. For example, the product can be a capsule, a time-release oral dosage, a powder, a gel, a sub-lingual tablet or any oral dosage product. In accordance with one aspect of the present invention, the capsule has the device positioned inside or secured to the interior. In an alternative arrangement, the device is secured to the exterior of the capsule or as part of the capsule wall.

[0049] In accordance with the teachings of the present, in some embodiments, the device is placed within the capsule. In accordance with other aspects of the present invention, the device is secured with the capsule. Various methods of securing the device to the capsule are disclosed. For example, the device may be secured to the capsule using ingestible glues, pressure sensitive adhesives, thermal adhesives, mechanically attached, secured to a band that is later placed around the product.

[0050] In addition to the methods used to secure the device to the product, there are various methods of coating or laminating the device, surrounding the device, or separating and isolating the device from the drug or product within the capsule to prevent a reaction between the device and the drug or product. For example, certain products contain acids that can damage the device, such as tartaric acid. Additionally, there are times when the device, upon activation may interact with the product or drug when the device is activated too quickly. Thus, as discussed in detail below, there are various lamination and packaging options that may be used in association with the device to prevent such problems.

[0051] Referring now to FIG. 1, an ingestible device 20 is shown with a layer 20a surrounding electronics 20b. The layer 20a is soluble and a disintegrating layer of material around the electronics 20b. The layer 20a delays the exposure of the electronics 20b to surrounding fluids. The device 20 is placed inside the capsule 22, which also contains a pharmaceutical product or drug. The capsule 22 has a bottom end 22a and a top end 22b. The capsule 22 is made of a dissolvable material, such as gelatin. Upon ingestion, the capsule 22 walls turn into a gel-like material, due to contact with fluids. The layer 20a prevents contact between the gel-like material of the capsule 22 and the electronics 20b until the gel-like material has dissolved and no longer interferes with the operation of the device 20. During the time the capsule 22 is dissolving, the layer 20a is also slowly disintegrating away to allow the electronics 20b to come into contact with the fluids and become activated. One example of the type of electronic components that are part of the device 20 is disclosed in U.S. patent application Ser. No. 12/564,017 filed on Sep. 21, 2009, which issued on Jul. 12, 2011 as U.S. Pat. No. 7,978,064 and is titled COMMUNICATION SYSTEM WITH PARTIAL POWER SOURCE, the entire disclosure of which is incorporated herein by reference. The capsule 22, in all instances described herein is intended to carry a drug and includes a drug product in addition to the device.

[0052] Referring now to FIGS. 2A and 2B, in accordance with another aspect of the present invention, the capsule 22 is shown with a device 24 inside the capsule. The device 24 includes a disintegrating film or material 24a and components and electronics 24b. In accordance with one embodiment, the device 24 has a laminated coating as shown in FIG. 2A. In accordance with another embodiment, the device 24 has is surrounded by the material 24a as shown in FIG. 28, As the capsule 22 is ingested, the capsule ends 22a and 22b disintegrate or dissolve. The content of the capsule 22 comes into contact with the surrounding fluids. The material 24a reacts with the fluids to prevent the gel-like material of the capsule 22 from coming into contact with the electronics 24b as discussed with respect to FIG. 2.

[0053] Referring now to FIG. 3, the capsule 22 is shown with a device 26 positioned within the capsule end 22b in accordance with another aspect of the present invention. The device 26 is held in position inside the capsule end 22b using friction or by a mechanical means as will be discussed with respect to FIGS. 4A and 4B, respectively. In accordance with various aspects of the present invention, the device 26 may be covered in a manner similar to the device 20 or the device 24 of FIG. 1 and FIGS. 2A and 2B, respectively. For example, the device 26 may include a layer or lamination material or the device 26 may include a disintegration material. As noted, the device 26 is held in position using friction or mechanical attachment.

[0054] Referring now to FIG. 4A, in accordance with one aspect of the present invention, the device 26 includes tabs or legs 28 and electronics 26b. The legs 28 are flexible and as the device 26 is pushed into the capsule end 22b, the friction between the legs 28 and the wall of the capsule end 22b hold the device 26 in place. As the capsule 22 dissolves, the walls of the capsule end 22b change shape or collapse causing the friction between the legs 28 and walls of the capsule end 22b to reduce and thereby allow the device 26 to be released from the capsule end 22b.

[0055] Referring now to FIG. 4B, in accordance with another aspect of the present invention, the device 26a includes tabs or legs 30 and electronics 26b. The legs 30 are used to secure the device 26a into a capsule end 22c. The capsule end 22b of FIG. 3 is replaced with the capsule end 22c. The capsule end 22c includes a matching number of slots or indentations 32 to the legs 30 of the device 26a, In an alternative aspect of the present invention, the number of legs 30 may differ from the number of slots 32. As the device 26a is pressed inside the capsule end 22c, the tabs 30 engage the slots 32 and lock the device 26a into place mechanically. As the capsule end 22c dissolves, the walls of the capsule end 22c change shape or collapse causing the device 26a to be released from the capsule end 22c.

[0056] Referring now to FIG. 5, the capsule 22 is shown with device 34 in accordance with another aspect of the present invention. The device 34 includes a material 34a to which is secured electronics 34b, similar to the electronics 24b, and a layer or covering 34c.

[0057] Referring now to FIG. 6 and FIG. 7, a process for creating a device with a covering or lamination is shown in accordance with one aspect of the present invention. Devices 40 are shown on a sheet 41 that is placed between a top lamination sheet 42a and a bottom lamination sheet 42b. The sheets 42a and 42b may be made of a variety of materials or films, such as polymer films that include polyethylene oxide, hydroxyprpyl cellulose, and triethyl citrate. Other films that can be used include any solulable polymer, plasticizer. The film provides a moisture barrier and dissolves under the proper conditions to delay activation of the device. The film layer is designed to provide sufficient delay in exposure of the device to the surrounding fluids relative to the disintegration and dispersion of the capsule material and the content of the capsule. The film layer may includes the soluble materials, barrier materials (such as lipids, polyvinyl alcohol), processing aids (such as plasticizers, adhesion promoters), and stabilizers. Furthermore, the film layer may be manufactured via lamination, application of a coating solution or slurry followed by a cure. In accordance with other aspects of the present invention, the film or layer may be similar to FIG. 2 and formed using dry compression, such as a tablet press.

[0058] There are a variety of active agents or pharmaceutical products that can be placed inside of a capsule. For example, there are FDA approved drugs, drugs that are disclosed chemically in a patent application or in an issued patent, there are drugs are disclosed in the Orange Book as part of the approved drug products, and generics. In accordance with the teachings of the present inventions, any one or combination of such drugs may be placed within the capsule along with the device. Each of those drugs will have a specific and unique impact on the operation of the device as well as the disintegration of the film used because of the unique chemical composition. As such, the type of material uses as the film layer will vary to be compatible to the chemical composition of the products used. Thus, the scope of the present invention is not limited by the type of content of the capsule and the film or coating layer around the electronic components of the device.

[0059] In accordance with another aspect and benefit of the present invention, the film or coating will also prevent the interaction components of the device with the drug inside the capsule and as such the device will not alter or impact the effectiveness of the drug.

[0060] As shown in FIG. 7, one example of the device 40 includes a skirt 40a with a plurality of holes 44 and electronics 40b. As the sheets 42a and 42b are subject to heating or pressure, then the sheets 42a and 42b are secured to each other through the holes 44 and the device 40 is securely held between the sheets 42a and 42b. As shown in FIG. 7, the device 40 is laminated between the sheets 42a and 42b. In accordance with another aspect of the present invention, the sheets 42a and 42b may have the portions for each device 40 punched, cut-out, or removed first and then positioned above and below the device 40. The portions are cut to be oversized. Thus, as the portions of the sheets 42a and 42b are exposed to heat or pressure, then the oversized portions at the edges are secured to each other forming a pocket that surrounds the device 40 as well as secured to in place through the holes 44 as noted above. In accordance with another aspect of the present invention, the holes 44 may be eliminated when the device is placed between the oversized portions and secured within a pocket that surrounds the device 40.

[0061] Referring now to FIG. 8 and FIG. 9, in accordance with one aspect of the present invention, a laminated device sheet 50 is positioned above a die 52 with a hole 52a in the die 52. Even though only one hole 52a is shown, it will be understood by those skilled in art that the die may include multiple holes and the example discussed with respect one, may be repeated for many. The hole 52a of the die 52 is positioned above a capsule holder 54 that contains a capsule end 56. As the sheet 50 is positioned above the hole 52a, a punch 58 is used to cut the device 50a out of the sheet 50 and insert the device 50a into the capsule end 56. As noted above in accordance with various aspects of the present invention, the device 50a can have a variety of shapes and those shapes can be created by the punch 58.

[0062] Referring now to FIGS. 10-14, in accordance with one aspect of the present invention, the device 40 of FIG. 6 may be punched out and placed inside a hole 62a of a transfer tray 62. The tray 62 is shown in FIG. 10 with a plurality of holes. As shown in FIG. 11, the tray 62 is positioned below a sheet of devices, such as the sheet 50 of FIG. 8. A punch blade 64 cuts a device 66 from the sheet of devices and inserts the device 66 into the hole 62a. The device 66 is held in place in the hole 62 with friction as shown in FIG. 12. The tray 62 is then advanced to the next step of the process and a punch press 70 pushes the device 66 into a capsule end 72 held within a capsule holder 74 as shown in FIGS. 13 and 14.

[0063] As noted above various disintegration materials may be used to surround the electronic components. For example, a disintegrant may be sodium starch glycolate or a water soluble excipient such as hydroxypropyl cellulose. It will also be apparent that the various layers disclosed can be eliminated or combined depending on the material employed and the properties thereof.

[0064] As described herein, a system of the present invention is used with a conducting fluid to indicate the event marked by contact between the conducting fluid and the system. For example, the system of the present disclosure may be used with a pharmaceutical product and the event that is indicated is when the product is taken or ingested. The term “ingested” or “ingest” or “ingesting” is understood to mean any introduction of the system internal to the in-vivo. For example, ingesting includes simply placing the system in the mouth all the way to the descending colon. Thus, the term ingesting refers to any instant in time when the system is introduced to an environment that contains a conducting fluid. Another example would be a situation when a non-conducting fluid is mixed with a conducting fluid. In such a situation the system would be present in the non-conduction fluid and when the two fluids are mixed, the system comes into contact with the conducting fluid and the system is activated. Yet another example would be the situation when the presence of certain conducting fluids needed to be detected. In such instances, the presence of the system, which would be activated, within the conducting fluid could be detected and, hence, the presence of the respective fluid would be detected.

[0065] It is noted that, as used herein and in the appended claims, the singular forms “a”, “an”, and “the” include plural referents unless the context clearly dictates otherwise. It is further noted that the claims may be drafted to exclude any optional element. As such, this statement is intended to serve as antecedent basis for use of such exclusive terminology as “solely,” “only” and the like in connection with the recitation of claim elements, or use of a “negative” limitation.

[0066] As will be apparent to those of skill in the art upon reading this disclosure, each of the individual embodiments described and illustrated herein has discrete components and features which may be readily separated from or combined with the features of any of the other several embodiments without departing from the scope or spirit of the present invention. Any recited method can be carried out in the order of events recited or in any other order which is logically possible.

[0067] Although the foregoing invention has been described in some detail by way of illustration and example for purposes of clarity of understanding, it is readily apparent to those of ordinary skill in the art in light of the teachings of this invention that certain changes and modifications may be made thereto without departing from the spirit or scope of the appended claims.

[0068] Accordingly, the preceding merely illustrates the principles of the invention. It will be appreciated that those skilled in the art will be able to devise various arrangements which, although not explicitly described or shown herein, embody the principles of the invention and are included within its spirit and scope. Furthermore, all examples and conditional language recited herein are principally intended to aid the reader in understanding the principles of the invention and the concepts contributed by the inventors to furthering the art, and are to be construed as being without limitation to such specifically recited examples and conditions. Moreover, all statements herein reciting principles, aspects, and embodiments of the invention as well as specific examples thereof, are intended to encompass both structural and functional equivalents thereof. Additionally, it is intended that such equivalents include both currently known equivalents and equivalents developed in the future, i.e., any elements developed that perform the same function, regardless of structure. The scope of the present invention, therefore, is not intended to be limited to the exemplary embodiments shown and described herein. Rather, the scope and spirit of present invention is embodied by the appended claims.