A method of analyzing fluid collected from a wound site, the method comprising the steps of: (a) providing a pump unit comprising: one or more pumps, one or more fluid collectors, and one or more drainage structures each in communication with an exit site of the wound site to draw the fluid through the one or more drainage structures into the pump unit and create a negative pressure at the exit site to remove and transport the fluid from the exit site and into the one or more fluid collectors, wherein the pump unit is configured to create a negative pressure, wherein the fluid removal from the exit site is provided at a controlled and measured rate; b) collecting the fluid within the one or more fluid collectors; c) removing the one or more fluid collectors; e) capping the one or more fluid collectors with a cap; and d) analyzing the collected fluid of step “b” once the fluid connectors are removed in step “c”.

Provided herein are compositions, methods, uses, and articles of manufacture for iodine treatment on mucosal membranes, and treatment of respiratory pathogens in this way—e.g., by inhalation and combined with the evaporation of steam. In certain embodiments, iodine treatment encompasses administration of compounds that release molecular iodine and/or physiologically active iodine-containing compounds.

A wound monitoring and/or therapy system can include a substantially stretchable substrate supporting a plurality of electronic components, including sensors, and a plurality of electronic connections that connect at least some of the electronic components. The electronic components can also include a circuit board supporting at least one controller configured to control at least some of the sensors, the circuit board configured to operate without failure when the substrate is flexed as a result of strain. A calibration track can be positioned on the substrate and connected to a monitoring circuit configured to measure a change in resistance of the calibration track indicative of resistance change of at least some of the plurality of electronic connections. The system can include a controller with a circuit board supporting a plurality of electrical components and an antenna configured to communicate with the substrate, the antenna at least partially enclosing the circuit board.

Systems and methods for delivering a drug or other therapy over an extended period of time (e.g., several hours, days, weeks, months, years, and so forth) are disclosed herein, as are systems and methods for monitoring various parameters associated with the treatment of a patient. Systems and methods are also disclosed herein that generally involve CED devices with various features for reducing or preventing backflow.

A multi-layer wound dressing comprises a carrier film comprising a transparent material or a semi-transparent material, and an adhesive layer comprising a silicone-based material and in contact with the carrier film and exhibiting a tackiness formulated and configured to decrease over a duration of time. Related multi-layer wound dressings are also disclosed.

Dialysis systems comprising actuators that cooperate to perform dialysis functions and sensors that cooperate to monitor dialysis functions are disclosed. According to one aspect, such a hemodialysis system comprises a user interface model layer, a therapy layer, below the user interface model layer, and a machine layer below the therapy layer. The user interface model layer is configured to manage the state of a graphical user interface and receive inputs from a graphical user interface. The therapy layer is configured to run state machines that generate therapy commands based at least in part on the inputs from the graphical user interface. The machine layer is configured to provide commands for the actuators based on the therapy commands.

A wound treatment system includes a housing. A processor is located in the housing. A pressure monitoring system is coupled to the processor. A power delivery system is located in the housing and coupled to the processor. An oxygen concentrator is located in the housing and coupled to the power delivery system. The oxygen concentrator includes a plurality of oxygen outlets. The processor is configured to receive pressure information from the pressure monitoring system that is indicative of a pressure in a restricted airflow enclosure provided by a dressing and located adjacent a wound site; and use the pressure information to control the power provided from the power delivery system to the oxygen concentrator in order to control an oxygen flow created by the oxygen concentrator and provided through one of the plurality of oxygen outlets to the restricted airflow enclosure.

The disclosed systems and methods provide a printed electronics breath indicator that may be directly printed or molded onto a manufactured breathing device, or separately attached to an existing breathing device. The printed electronics breath indicator may include an electroluminescent indicator, a sensor, and a processor. The processor may be configured to receive sensor data from the sensor, the sensor data including detected carbon dioxide (CO2) or oxygen (O2) levels. The processor may be further configured to determine a current breathing state of the patient based on the received sensor data. The processor may be further configured to cause the electroluminescent indicator to generate a visual representation according to the determined current breathing state of the patient. The visual representation may comprise a variable visual representation that displays one or more visual parameters that are proportional to the detected CO2 or O2 levels.

Some aspects of the present disclosure relate to a drive mechanism for a drug delivery device. The drive mechanism includes: a piston rod to operably engage with a piston of a cartridge to displace the piston in a distal direction during a dose dispensing action, at least one actuation member mechanically coupled with the piston rod to induce a distally directed displacement of the piston rod when actuated by a user, a control to ascertain at least one predefined condition of use, and at least one interlock member coupled with the control to mechanically obstruct displacement of the piston rod if the condition of use is not fulfilled.

A portable hemodialysis system is provided including a dialyzer, a closed loop blood flow path which transports blood from a patient through the dialyzer and back to the patient, and a closed loop dialysate flow path which transports dialysate through the dialyzer. Preferably, the hemodialysis system comprises a sorbent filter in the dialysate flow path. Furthermore, the hemodialysis system comprises a dialysate quality sensor disposed directly in the dialysate flow path. The dialysate quality sensor is configured to change color based on a pH level, ammonia level, or ammonium level of the dialysate.