The principles and embodiments of the present invention relate to methods and systems for safely providing NO to a recipient for inhalation therapy. There are many potential safety issues that may arise from using a reactor cartridge that converts NO.sub.2 to NO, including exhaustion of consumable reactants of the cartridge reactor. Accordingly, various embodiments of the present invention provide systems and methods of determining the remaining useful life of a NO.sub.2-to-NO reactor cartridge and/or a breakthrough of NO.sub.2, and providing an indication of the remaining useful life and/or breakthrough.

A patient interface device includes a frame having a central portion with a patient facing side, an opposite outward facing side, a first plurality of magnetic elements secured on or in the patient facing side, and a first aperture defined therethrough. The first aperture having a first portion extending from the outward facing side toward the patient facing side which is structured to be coupled to a delivery conduit and a patient side portion defined by a wall which extends outward from the patient facing side forming a hub. The device further includes a cushion having a patient contacting side which is structured to sealingly engage about an orifice or orifices of a patient, an opposite frame contacting side including a second aperture defined therein which is sized and configured to engage about the hub, and a second plurality of magnetic elements for magnetically coupling the cushion to the frame.

A medicament delivery device is presented having a housing that is arranged to accommodate a medicament container; a drive unit operably arranged to act on the medicament container upon activation; an activation mechanism operably arranged to be operated by a user; an activation preventing mechanism operably arranged to prevent said activation mechanism to be activated; an identification module arranged to be operated by a user, which identification module is designed as an attachable unit to the medicament delivery device; mechanical keying elements arranged on said device and on said identification module designed to interact with each other when attaching said identification module; first electrical keying elements comprised in said identification module, wherein said electrical keying elements are capable of obtaining identification information, such that the identification information obtained is compared to stored data and authenticated by the identification module, and wherein the authentication causes a deactivation of the activation preventing mechanism to allow operation of the activation mechanism.

The present disclosure relates to an aerosol delivery device that includes a reservoir housing that defines a mouthpiece channel. The aerosol delivery device includes a sealing member configured to be received within the reservoir housing to define a reservoir chamber configured to retain an aerosol precursor composition therein. The aerosol delivery device also includes a substrate member that is configured to be received within the reservoir housing and to be directly engaged with a vaporizing assembly for forming an aerosol. The reservoir housing, sealing member, substrate member, and/or vaporizing assembly can be used for forming aerosols with precise and reproducible compositions.

A pump for treating a patient is disclosed that includes a spring-biased plunger biased toward actuation against a tube; a cam shaft configured to actuate the spring-based plunger; a lever actuatable between a closed position and an open position; a shaft coupled to the lever, the shaft having a central axis centrally along the length of the shaft, the shaft coupled to the lever to rotate around the central axis in accordance with actuation of the lever; and a lift cam pivotally coupled to the shaft, wherein the lift cam pivots around a lift cam axis, the lift cam axis of the lift cam is parallel to the central axis of the shaft, and the lift cam engages with the spring-based plunger to lift the spring-biased plunger off of the cam shaft as the shaft rotates in accordance with actuating the lever to the open position.

The present disclosure provides an aerosol precursor consumable, and an aerosol delivery device that comprises a control unit that defines a receiving chamber, and a removable and replaceable aerosol precursor consumable, at least a portion of the consumable configured to be received into the receiving chamber. The aerosol precursor consumable comprises a housing defining an outer wall, an aerosol precursor composition reservoir located in the housing and configured to contain an aerosol precursor composition, an atomizer located in the housing, and at least one aroma diffuser. The atomizer is configured to vaporize the aerosol precursor composition to generate an aerosol for oral delivery to a user, and the at least one aroma diffuser is configured to diffuse an aroma composition for olfactory delivery to the user.

An electronic module is configured for attachment to a proximal end of a drug delivery device in a predefined fastening configuration. The drug delivery device comprises an elongated housing extending in a longitudinal direction and comprising a distal end and the proximal end. The electronic module comprises a mechanical coding comprising a mechanical coding feature to engage with a mechanical counter coding feature of a mechanical counter coding provided at the proximal end of the drug delivery device, wherein one of the mechanical coding feature and the mechanical counter coding feature comprises a protrusion extending in the longitudinal direction and wherein the other one of the mechanical coding feature and the mechanical counter coding feature comprises a recess, wherein, in some configurations, the mechanical coding and the mechanical counter coding are operable to prevent a fastening of the electronic module to the drug delivery device.

A refill for an inhaler, the refill including a cylinder with an axis and containing a pressurised inhalable composition. An outlet valve at one end has a hollow valve stem extending axially from the cylinder. A cap is fitted onto the cylinder at the outlet end and extends axially beyond the valve stem. The cap has an internal passage extending through the cap to allow access to the valve stem. The internal passage provides a guide wall to guide the inhaler onto the stem during the refill process.

A foam inhalation device (874) for dispensing a foam to be inhaled by a user. The inhalation device (874) comprises a foam-generating component for generating the foam, an outlet (882) for dispensing the foam to the user, and a fluid flow path which fluidly communicates the foam-generating component with the outlet (882). The foam is generatable by the foam-generating component and flows to the outlet (882) via the fluid flow path to be inhaled by the user.

In an embodiment, a connector or connector assembly for attaching a nasal cannula with a gas delivery hose includes a sensor port for a sensor probe positioned near an end of a nasal cannula, which can allow the sensor probe to be placed closer to the patient's nostrils than previous connector parts allowed. The connector can be configured to advantageously allow the nasal cannula to rotate relative to the gas delivery hose, thereby allowing a patient or healthcare provider to untangle or otherwise straighten the hose or the cannula. The connector assembly can be configured to automatically align locking protrusions on a first component with locking recesses on a second component, where insertion of the second component within the first component causes the second component to rotate relative to the first component, thereby aligning the locking protrusions with associated locking recesses.