Techniques are disclosed for reducing the accumulation of gases in an implantable infusion device. In one example, an implantable infusion device (IID) includes a housing, an expandable and contractible reservoir, and a standoff member. The expandable and contractible reservoir is configured to store a therapeutic agent and is arranged within the housing. A first end of the reservoir is configured to collapse toward a second end of the reservoir as the reservoir contracts. The standoff member is interposed between the first end and the second end of the reservoir and is configured to hold at least a portion of the first end offset from the second end when the reservoir is in a contracted state.

A medicament delivery device (10) comprising a syringe (12) having a barrel with an open end, and an axially moveable stopper (18) received in the barrel separating a first chamber axially forwards of the stopper from a second chamber axially rearwards of the stopper. The medicament delivery device further including an expandable drive housing (24) arranged to receive a propellant from a propellant source (36) for providing a vapour pressure, the expandable drive housing having a narrow channel in fluid communication with the second chamber. The expandable drive housing is expandable upon receiving propellant from the propellant source and, upon expansion, causes forward axial movement of the syringe. Propellant introduced into the expandable housing may pass through the narrow channel into the second chamber and cause forward axial movement of the stopper in the barrel to expel medicament contained in the first chamber through the open end, where axial movement of the stopper in the barrel commences after axial movement of the syringe.

A medicament delivery device for delivering a liquid medicament, the medicament delivery device comprising: a rigid casing containing a deformable medicament container, the deformable medicament container arranged to contain the liquid medicament; a pressurized gas cartridge connected to the rigid casing via a gas valve; wherein the gas valve is releasable to allow gas flow into the rigid casing to cause an increase in gas pressure in the rigid casing so as to compress the deformable medicament container to displace the liquid medicament.

A pneumatic needle-free injection device restores pressured air in a pressure room to deliver high pressure air instantaneously, so as to inject the dose subcutaneously, intradermally and intramuscularly, accelerating absorption process of skins. The device can be further linked to a high-pressured air container for portable usage.

The present invention generally relates to hemodialysis and similar dialysis systems, including a variety of systems and methods that would make hemodialysis more efficient, easier, and/or more affordable. One aspect of the invention is generally directed to new fluid circuits for fluid flow. In one set of embodiments, a hemodialysis system may include a blood flow path and a dialysate flow path, where the dialysate flow path includes one or more of a balancing circuit, a mixing circuit, and/or a directing circuit. Preparation of dialysate by the preparation circuit, in some instances, may be decoupled from patient dialysis. In some cases, the circuits are defined, at least partially, within one or more cassettes, optionally interconnected with conduits, pumps, or the like. In one embodiment, the fluid circuit and/or the various fluid flow paths may be at least partially isolated, spatially and/or thermally, from electrical components of the hemodialysis system. In some cases, a gas supply may be provided in fluid communication with the dialysate flow path and/or the dialyzer that, when activated, is able to urge dialysate to pass through the dialyzer and urge blood in the blood flow path back to the patient. Such a system may be useful, for example, in certain emergency situations (e.g., a power failure) where it is desirable to return as much blood to the patient as possible. The hemodialysis system may also include, in another aspect of the invention, one or more fluid handling devices, such as pumps, valves, mixers, or the like, which can be actuated using a control fluid, such as air. In some cases, the control fluid may be delivered to the fluid handling devices using an external pump or other device, which may be detachable in certain instances. In one embodiment, one or more of the fluid handling devices may be generally rigid (e.g., having a spheroid shape), optionally with a diaphragm contained within the device, dividing it into first and second compartments.

The invention is configured so that pressurized gas from a pressurized gas supply source passes through a pressurized gas channel provided in a main body of a powder spraying device and is sprayed out. A powder container containing powder such as medical agents is provided on the main body. The powder within the powder container is supplied to the pressurized gas channel and is sprayed together with the pressurized gas. An eccentric rotor with a center of gravity deviated from a center of rotation is provided in the main body. When spraying the powder together with the pressurized gas, vibrations are applied to the main body and the powder container by a rotation of the eccentric rotor. The powder can be thereby mixed more evenly with the pressurized gas.

An object of the present invention is to provide a cardiopulmonary resuscitation system in which a cardiopulmonary resuscitation device is made compact and which is capable of performing blowing of breathable gas into a patient at more appropriate timing. A cardiopulmonary resuscitation system (1) according to the present invention is equipped with a cardiopulmonary resuscitation device (100), an artificial respirator (200), and a signal transmission unit (300) which transmits an external signal to an external signal input unit (140) from an external signal output unit (240), and has a local mode in which a first gas blowing unit (110) and a chest compression unit (120) are operable and a second gas blowing unit (210) is stopped, and a remote mode in which the chest compression unit and the second gas blowing unit are operable and the first gas blowing unit is stopped, and in the remote mode, the cardiopulmonary resuscitation device and the artificial respirator are capable of transmitting an external signal by the signal transmission unit, and a second control unit (230) controls the chest compression unit.

Injector devices and methods for using them to deliver medicament into a patient's body, e.g., sub-retinally within an eye, are provided. The injector includes a cartridge including a piston slidably disposed within an interior for delivering medicament within the interior through an outlet, and a driver including a plunger coupled to the piston, a source of pressurized fluid, and an actuator member for opening a flow path at least partially between the source and the plunger to advance the plunger and piston to deliver medicament from the interior. One or more sensors are operatively coupled to the plunger to measure displacement of the plunger, a processor is coupled to the sensor(s) for analyzing sensor signals to measure volume of medicament delivered from the interior, and an output device, e.g., one or more LEDs or speakers, provide outputs related to the volume of medicament delivered.

A process and a nebulizer for dispensing a consecutively dose of medicament in the form of a mist, comprising: an energy source (ES), an air-conditioning volume, an air outlet fluidity connected to the air-containing volume, an air actuator adapted to release a flow of compressed air through the air outlet at such time as a predetermined ES pressure has been reached in the volume and at least two valve means in communication with the air actuator. The compressed air is released at a predetermined pressure of about 20 to about 100 psig. The valve means controls the actuation of the air actuator such that when a medication is nebulized, a mist distribution of a medication is formed having droplets size in the range of approximately 1 to approximately 7 which inhaled by a user at a set of predetermined intervals.

A device for transplanting body fat includes a chamber in the form of a hollow cylinder divided by a plunger guidable on an inner casing surface of the chamber into a proximal portion and a distal portion which is fluidically decoupled from said proximal portion. A piston connected to the plunger has an end which has a fluidic connection extending through the plunger to the chamber, and the plunger is configured as a filter in the region of the fluidic connection, and the distal end of the piston comprises a first closable media connection and means for guiding fluids and/or fatty tissue are connectable to the chamber, wherein fluid and/or fatty tissue can be sucked into the proximal portion of the chamber and/or in through the plunger by supplying the first media connection in the open state with a negative pressure.