A patient interface includes: a plenum chamber; a seal-forming structure; a positioning and stabilising structure; a plenum chamber insert configured to be positioned and retained within the plenum chamber; and a vent structure; wherein the plenum chamber insert has a plenum chamber insert port; wherein the plenum chamber insert has an exterior surface configured to be positioned adjacent to an interior surface of the plenum chamber; wherein when the plenum chamber insert is positioned and retained within the plenum chamber, a radial channel is formed by the interior surface of the plenum chamber and the exterior surface of the plenum chamber insert such that gas is able to pass between a patient-proximal side of the plenum chamber insert and a patient-distal side of the plenum chamber insert via the radial channel during use.

A cannula for providing respiratory therapy to a patient includes a first nasal prong having a proximal end attached to a cannula body and a distal end for insertion into a nare of the patient. The first nasal prong defines a lumen for a flow of breathing gas from a source of breathing gas to the nare of the patient, and the first nasal prong has a variable geometry such that a cross-sectional area of the lumen at the distal end of the first nasal prong varies with a flow rate of the breathing gas. Varying the cross-sectional area of the first nasal prong lumen with the flow rate of the breathing gas enables the first nasal prong to maintain a high velocity flow to the nare for effective flushing of the patient's airway.

An apparatus for humidification of air to be delivered to a patient's airways may include a reservoir, and a humidifier chamber. The humidifier chamber may include a humidifier wick and a heating element for heating the humidifier chamber. The humidifier wick may comprise a fibrous sheet material. The humidifier chamber and wick may be vertically oriented in use such that a first end of the wick is above the second end of the wick. A deioniser may be provided to deionise the liquid prior to the humidifier wick. The apparatus may pasteurise liquid to be delivered to the humidification wick.

A dry powder inhaler including replaceable cartridges containing a dry powder for local or systemic delivery through the pulmonary tract and lungs is disclosed. The inhalers are used with inhalable dry powders, including medicament formulations comprising active agents for local or systemic delivery and for the treatment of diseases such as, pulmonary hypertension, cardiovascular disease, anaphylaxis, diabetes, obesity, cancer, and other diseases, or symptoms associated with these and other diseases, such as nausea, vomiting, pain and inflammation.

A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising: a substance supply unit for supplying a dose of substance to be delivered to the nasal cavity of the subject, the substance supply unit including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the substance supply unit; and a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the substance supply unit and through which the subject in use exhales such as to entrain substance from the container chamber and deliver the same through the nosepiece, and at least one temperature modifier for reducing a temperature of the exhaled air flow such as to reduce the absolute humidity thereof.

A respiratory therapy system can have a flow generator adapted to provide gases to a patient. A gas passageway can be located in-line with the flow generator. The gas passageway can have a first portion adapted to receive a first gas and a second portion adapted to receive a second gas. The gas passageway can have a static mixer downstream of the first and second portions.

An arrangement for an inhaler comprises at least one electric evaporator for evaporating liquid supplied from the evaporator, and for adding the evaporated liquid to an air flow flowing through the inhaler to form an aerosol, and a flow rate measuring arrangement for measuring the volume and/or mass flow of the air flow flowing through the inhaler. The flow rate measuring arrangement comprises a heating device, a downstream temperature sensor arranged downstream of the heating device for measuring an air outlet temperature and an electronic control device, wherein the electronic control device is adapted to determine the volume and/or mass flow of the air flow flowing through the inhaler on the basis of a temperature difference between the air outlet temperature and an air inlet temperature of the air flow upstream of the heating device.

Disclosed are dry powder inhalers for delivering medicament to a user from a blister pack, the blister pack having a plurality of spaced-apart blister pockets containing doses of the medicament. The inhalers comprise: a housing for accommodating unused and used portions of the blister pack together with a dispensing mechanism for selectively opening the blister pockets; and a manifold component through which air can be drawn in use of the inhaler. The manifold component comprises: a primary air inlet opening for receiving first external air; an air outlet opening for providing the external air from the primary air inlet opening into an opened blister pocket, the primary air inlet opening being fluidly connected to the air outlet opening by a primary air delivery conduit formed in the manifold component; a medicament inlet opening for receiving air-entrained medicament from the opened blister pocket, the air outlet opening and the medicament inlet opening being arranged side-by-side to enable simultaneous communication with the opened blister pocket; and a medicament outlet opening for delivery of the air-entrained medicament from the opened blister pocket to the user, the medicament inlet opening being fluidly connected to the medicament outlet opening by a medicament delivery conduit formed in the manifold component. The disclosed inhalers embodiments provide a variety of improvements to the design of the manifold component.

An apparatus is provided to change the absolute humidity of a flow of air for delivery to an entrance of the airways of a patient, the change being compared to the absolute humidity of ambient air. The apparatus has a reservoir configured to hold a volume of liquid. A heating element creates vapour from the liquid. A chamber is provided to mix the flow of air with the vapour. The apparatus has a body having a first wall structure with a chamber inlet port. A closure element having an air inlet port for pneumatically connecting to a source of the flow of air is secured to the body to provide a sealed gas flow path between the air inlet port and the chamber inlet port, and a liquid trap in the gas flow path.

Disclosed herein are aspects of portable vaporizers to deliver aliquots of heated air to material in a furnace. The furnace is multipurposed reducing heat loss, air leakage and delays in availability of air aliquots at the proper temperature for use. By dividing the furnace with an air permeable divider and placing material in the chamber a controller selectively providing electrical power to a heating element configured to heat air furnace. Upon application of suction to the fluid passage heated air passes through a divider which shapes the head of the heated plume before the aliquot of air reaches the material. A controller in signal communications with at least one temperature sensor controls the power flow to a heater to control the temperature produced by heating element(s).