An aerosol generator for an aerosol dispenser is presented where, the aerosol generator has a housing having an inlet part comprising a liquid inlet configured to guide a liquid jet (L) into the housing and an air inlet configured to guide an air flow into the housing. The housing further having an outlet part having an aerosol outlet configured to guide an aerosol (C) of liquid mixed with air out of the housing. The air inlet is configured such that at least part of the air flow entering the housing through the air inlet is obstructed at a distance from the liquid jet (L) entering the housing through the liquid inlet, thereby creating a source of turbulence in the housing to interact with droplets of the liquid jet (L) to prevent coalescence of the droplets.

A filter device includes a distal housing comprising a distal inner port and a distal outer port; a proximal housing comprising a proximal inner port and a proximal outer port, the proximal housing being sealingly affixed to the distal housing to form an inspiratory pathway between the distal inner port and the proximal inner port and to form an expiratory pathway between the distal outer port and the proximal outer port that is fluidly sealed from the inspiratory pathway, the inspiratory pathway being laterally adjacent the expiratory pathway; and a first filter in the inspiratory pathway or in the expiratory pathway to filter gases flowing through the inspiratory pathway or the expiratory pathway.

A thermally modulating inhalable medicament delivery device may deliver an inhalable medicament as an aerosol, vapor, or partial aerosol and partial vapor mixture. The inhalable medicament may be delivered to a target in a subject. Described herein are devices, systems, and methods for delivering an inhalable medicament to a subject.

A method for infusing a liquid into a patient's vasculature in accordance with an infusion protocol is disclosed. For this method, an infusion catheter having a multi-lumen infusion unit that is mounted adjacent the catheter's distal end is positioned in an artery within a predetermined distance from an intended target tissue surface. An inflation balloon is then deployed to at least partially occlude the artery and a force is exerted on the liquid to establish a flow rate for the liquid in the catheter. Specifically, the force is exerted to infuse the liquid from the catheter through the infusion unit and into the vasculature with a homogeneous distribution of the liquid to cover the intended surface of the target tissue. The flow rate can be established in accordance with an infusion protocol that is characterized by time and liquid volume parameters based on viscosity and pressure values in the liquid.

An instrument with a first conduit for emitting a first fluid from a first opening of the first conduit in an axial direction into a reacceleration zone and with a second conduit for channeling of a second fluid in the reacceleration zone in axial direction is provided such that active ingredient components, e.g. cells, of the second fluid are reaccelerated in axial direction as a result of the flow in the reacceleration zone by means of the first fluid that enters the reacceleration zone. A coaxial configuration of the first and the second conduit is preferred, because in doing so, around the first opening a shell jet of second fluid can be created that flows downstream in axial direction around the central working jet. In addition, a head for an inventive instrument and an application system with an inventive instrument is provided.

A thermally modulating inhalable medicament delivery device may deliver an inhalable medicament as an aerosol, vapor, or partial aerosol and partial vapor mixture. The inhalable medicament may be delivered to a target in a subject. Described herein are devices, systems, and methods for delivering an inhalable medicament to a subject.

The present disclosure pertains to a system and method for facilitating pressure support therapy, mechanical inexsufflation therapy, and suctioning therapy for a subject. The system and method described herein offer a novel combination of mechanical inexsufflation with suctioning from a vacuum system. The invasive nature of current closed suctioning systems poses many potential risks, such as tissue trauma, less optimum secretion clearance at the peripheral airway, and lung decruitment. The system and method described herein provide a non-invasive method of suctioning with a suctioning volume measurement and a monitoring alarm to ensure a baseline lung volume and a positive end expiratory pressure (PEEP) level are maintained. This non-invasive method of suctioning is provided together with mechanical inexsufflation and pressure support therapy.

Containment units, dry powder inhalers, delivery systems, and methods for the same are disclosed. Exemplary devices are configured to have inlets and outlets which are formed with the containment walls of a containment unit. Air jets formed by the configuration of inlet(s) and outlet(s) inside the containment unit create significant turbulence and deaggregate the powder. Delivery system components downstream of the containment unit may integrate the exiting aerosol plume with a low flow nasal cannula air stream for delivery to a subject.

Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.

An atomizer includes a central region, a marginal region, a liquid storage tank assembly defining a first hole, a base assembly including a base body including an accommodating room and inlet holes, and an atomization core assembly. The atomization core assembly includes an atomizing member including an atomizing room and a diverting member including a diverting room including a swirling flow region having a second hole and a straight flow region including first airflow holes and first diverting plates. Air flows into the accommodating room from the inlet holes, one part of the air flows through the second hole, the atomizing room, and the first hole in a swirling state, and forms a swirling flow in the central region; the other part of the air flows through the first airflow holes, the atomizing room, the first hole in a straight state, and forms a straight flow in the marginal region.