The present disclosure describes a system for the delivery of therapeutic substances to the cavities of a patient. The system can include a wearable micropump that is fluidically coupled with a handpiece. The handpiece can be inserted, for example, into the middle ear via a surgical tympanotomy approach. The system can enable a controlled injection of a therapeutic substance directly into the patient's cavity.

A surgical cassette for an ophthalmic surgical system includes an irrigation system, an aspiration system, and a computer. The irrigation system is in fluid communication with a handpiece and carries fluid toward a surgical site. The aspiration system is in fluid communication with the handpiece via an aspiration conduit and carries fluid away from the surgical site. The computer instructs the aspiration system to vibrate fluid back and forth within the aspiration conduit to perform a priming procedure.

A surgical cassette for an ophthalmic surgical system includes an irrigation system and an aspiration system. The irrigation system is in fluid communication with a handpiece and carries fluid toward a surgical site. The aspiration system is in fluid communication with the handpiece and carries fluid away from the surgical site. The aspiration system includes an aspiration pump and tubing of an aspiration conduit. The aspiration pump generates a normal vacuum pressure within the aspiration conduit to carry fluid away from the surgical site during normal operation. The tubing has a larger cross-sectional area in response to normal vacuum pressure. The tubing collapses from the larger cross-sectional area to a smaller cross-sectional area in response to an occlusion; maintains the smaller cross-sectional area during a post-occlusion break surge to mitigate the post-occlusion break surge; and returns to the larger cross-sectional area after the post-occlusion break surge.

The present invention relates to an ultrasound contrast agent for use in treating a retina disorder by transiently disrupting the blood-retinal barrier (BRB) of a human, wherein the ultrasound contrast agent is administered just before and/or during the application, to the retina of the human, of an unfocused ultrasound (US) beam. The present invention further relates to a therapeutically active agent for use in treating a retina disorder in a human, wherein the therapeutically active agent is to be delivered in combination with an ultrasound contrast agent, which is administered before and/or during the application, to the retina of the human, of an unfocused ultrasound (US) beam in order to transiently disrupting the blood-retinal barrier (BRB) of the human, to allow the therapeutically active agent to cross the BRB and to target the retina. The present invention also relates to an eye ultrasound delivery device that may be used to treat a retina disorder.

A surgical cassette for an ophthalmic surgical system comprises an irrigation system and an aspiration system. The irrigation system is in fluid communication with a handpiece and carries fluid toward a surgical site. The aspiration system is in fluid communication with the handpiece via an aspiration conduit, and carries fluid away from the surgical site. The aspiration system comprises a chamber that expands to store fluid, and collapses to move the fluid to meet a volume demand in the aspiration conduit to mitigate a post-occlusion break surge.

Provided herein are needle assemblies for intravitreal injection of an implant into an eye of a patient through an unsheathed state and a sheathed state. Such needle assemblies are precise and accurate for proper treatment and prevent further damage to the eye.

An ocular implant for treating glaucoma is provided, which may include any number of features. More particularly, the present invention relates to implants that facilitate the transfer of fluid from within one area of the eye to another area of the eye. One feature of the implant is that it includes a proximal inlet portion and a distal inlet portion adapted to be inserted into the anterior chamber of the eye, and an intermediate portion adapted to be inserted into Schlemm's canal. Another feature of the implant is that it can be biased to assume a predetermined shape to aid in placement within the eye.

A synthetic eye model is provided which can include a number of features. In one embodiment, the synthetic eye can include a rigid or semi-rigid eye shell, a synthetic iris base positioned within the eye shell, an eye core positioned within the eye shell and encircling the synthetic iris base, the eye core including a channel integral to the eye core configured to replicate Schlemm's canal of a human eye, and a synthetic trabecular meshwork tissue coupled to the eye shell and extending across the channel. Methods of using the synthetic eye model are provided, including using the synthetic eye model as a surgical training tool.

A foot pedal device configured to provide force feedback to an operator during ophthalmic surgery is described. The foot pedal device includes a processor and a memory containing instructions which, when executed by the processor, cause the processor to transmit, in response to a movement of a moveable member, a control signal to a surgical console for initiating an action of an ophthalmic surgery tool coupled with the surgical console. The foot pedal device includes a force feedback mechanism configured to selectively apply a resistance force in opposition to the movement of the movable member. The memory contains instructions which, when executed by the processor, cause the processor to receive, from the surgical console, a trigger signal, and send a force feedback signal to the force feedback mechanism. The force feedback mechanism is configured to apply the resistance force to the movable member upon receiving the force feedback signal.

An apparatus, system and method of controlling the flow rate of an irrigation fluid. The apparatus, system and method include modifying a pressure gravitationally above the irrigation fluid in a fluid reservoir to increase the flow rate through a surgical pack by iteratively controlling infusion of gas to the fluid reservoir. The iteratively controlling comprises sensing an in-range response to said modifying, wherein the infusion of gas is enabled; and sensing an out-of-range response to said modifying. If, based on prior ones of said modifying: the out-of-range response poses no danger to a patient, the infusion of gas is enabled; the out-of-range response poses a substantial danger to the patient, the infusion of gas is disabled; or the out-of-range response poses no substantial danger to the patient, the iteratively controlling comprises applying a successive series of modifications to correct the out-of-range response.