An instrument for isolating candidate eyelashes to attach prostheses includes an instrument tip which has a tip aperture. A candidate eyelash is disposed in a distal slot of the tip aperture. The instrument tip is advanced relative to the candidate eyelash and the instrument tip applies a force to eyelashes that are adjacent to the candidate eyelash. The application of the force actuates the eyelashes that are adjacent to the candidate eyelash away from the candidate eyelash. The candidate eyelash is actuated into an open area of the tip aperture and a prosthesis is attached to the candidate eyelash.

Glaucoma shunts for draining fluid from an eye to surrounding tissue and being implantable within eye tissue, the shunts include a shunt body formed from microporous materials arranged to form a reservoir within the shunt body, and a conduit having a proximal end in fluid communication with the reservoir and an opposing distal end, the distal end being insertable into the eye to facilitate drainage of fluid into the conduit via the distal end, wherein the conduit and the reservoir together define a flow passage along which drainage of fluid flows through the conduit, to the reservoir, and into surrounding tissue via the microporous material, wherein the flow passage presents a variable flow resistance along the conduit that has a plurality of sequential flow resistances with first and second flow resistances defined therein such that the first flow resistance is different from the second flow resistance.

A glaucoma shunt for draining a fluid from an eye to a tissue surrounding the eye, the glaucoma shunt being implantable within tissue of the eye, the glaucoma shunt includes a shunt body that is formed from a microporous material that is arranged so as to form a reservoir within the shunt body; and a conduit in fluid communication with the reservoir, the conduit being insertable into the eye such that the fluid at a distal end of the conduit is allowed to flow through the conduit and accumulate within the reservoir, wherein the microporous material transitions from a hydrophobic state to a hydrophilic state as the fluid that is accumulated in the reservoir diffuses to the tissue surrounding the eye through the microporous material so as to provide a variable flow resistance as the microporous material transitions from the hydrophobic state to the hydrophilic state.

A cannula holder capable of securing a cannula to the holder at the time of piercing work, and easily removing the cannula from the holder using tweezers or the like. The cannula holder, to which a piercing needle for piercing an eyeball and a cannula are attached when attaching the cannula used in ophthalmic operations to the eyeball, includes claw portions that are formed on a front end of the cannula holder and which press sides of the cannula either at positions where said claw portions face each other or from multiple directions. A depression may be provided in a side of the front end of the cannula holder, allowing visibility of a part of a back end of the cannula from the depression.

The invention provides liquid formulation compositions and medicament delivery devices, and methods for preparing and using the same. For example, the liquid formulation composition is an emulsion including a solvent and liquid particles, which includes surfactants and are dispersed in the solvent. The volume average particle size of the liquid particles is less than about 100 μm; the surface tension of the liquid formulation composition is less than about 60 mN/m; and the absolute value of zeta potential is greater than about 15 mV. The containment vessel may be a sprayer or a dropping device. The invention also provides methods for preparation of the liquid formulation compositions and medicament delivery devices as well as methods for using the same in treatment of various diseases and condition, for example, otitis media, otitis externa, rhinitis, sinusitis, lower respiratory tract inflammation, xerostomia (dry mouth), xerophthalmia (dry eyes) and xeromycteria (dry nose).

This invention relates to a device and method for the vacuum-assisted delivery of drugs through an intact surface membrane of an organ.

A phacoemulsification system that includes a hand-graspable body and a phacoemulsification needle extending from a distal portion of the body is disclosed herein. The phacoemulsification system may also include an impeller pump carried by the hand-graspable body and configured to convey an aspiration fluid from a surgical site. The impeller pump may include an aspiration motor and a flexible impeller coupled to and rotatably driven by the aspiration motor. The flexible impeller may be arranged to aspirate fluid and emulsified lens tissue from the surgical site.

A system for controlling aspiration of a phacoemulsification probe inserted into an eye includes an anti-vacuum surge (AVS) module, one or more sensors, a vacuum relief valve, and a processor. The AVS module is coupled with an aspiration channel of the probe and is configured to mitigate vacuum surges in the channel by regulating flow via the channel. The one or more sensors are configured to measure fluid parameters in the channel. The vacuum relief valve, which is fluidly coupled with the channel, is configured to controllably relieve vacuum in the channel. The processor is configured to identify a change in at least one of the fluid parameters by reading at least one of the one or more sensors, and, responsively to an identified change in fluid parameters, operate the vacuum relief valve using pulse width modulation (PWM) to maintain a pressure in the channel within a predefined range.

An ocular implantation device comprises a housing having a longitudinal axis, a needle configured to receive an implant, and a plunger and a rod operatively coupled together. The plunger and the rod are disposed in the housing and are collectively, translationally moveable along the longitudinal axis of the housing. The rod is configured to be receivable within at least a portion of the needle to enable the rod to move the implant therethrough. An actuator is operatively engaged with the plunger such that movement of the actuator in a direction aligned with the longitudinal axis of the housing results in the translational movement of the plunger and the rod along the longitudinal axis of the housing in order to deliver the implant through the needle to a target site. An alternative embodiment of an ocular implantation device uses a retractable needle to deliver an implant.

A surgical system comprises a pressurized irrigation fluid source; an irrigation line fluidly coupled to the pressurized irrigation fluid source; a hand piece fluidly coupled to the irrigation line; an irrigation pressure sensor located at or along the pressurized irrigation fluid source or irrigation line; and a controller for controlling the pressurized irrigation fluid source. The controller controls the pressurized irrigation fluid source based on a reading from the irrigation pressure sensor and an estimated flow value modified by a compensation factor.