A vacuum sponge system, comprising: a sponge having an outer surface, a proximal end and a distal end, spaced from the proximal end in an axial direction of the sponge; a drainage tube disposed partially in the sponge, and is in fluid communication with the sponge; the drainage tube is connectable with a vacuum pump such that a pressure is applicable to the outer surface of the sponge; and a delivery member having an outer surface and extending in an axial direction of the sponge and adapted to establish a fluid communication between a region from the distal end of the sponge and region from the proximal end of the sponge. The pressure provided by the pump via the drainage tube is applied to a vicinity of the outer surface of the delivery member and the outer surface of the sponge. The delivery member is disposed partially radially outside of the sponge.

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade within the wall to release the drug to produce a therapeutic effect. The preparation can be coupled to a delivery mechanism having one or more balloons or other expandable devices which are expandable responsive to a condition in the small intestine or other GI lumen to advance the preparation out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.

Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents (TA) within the GI tract and in particular to an antrum wall (AW). Particular embodiments provide a swallowable device (SD) such as a capsule for delivering drugs or other TA into the AW. The SD may contain a pressure sensitive component or assembly which triggers release and insertion of a therapeutic agent preparation (TAP) comprising at least one TA into the AW in response to external pressure, such as pressure applied to the swallowable capsule or other SD by antrum contractions. Particular embodiments of the SD may be shaped so that they self-align within an antrum to properly orient before injection of the TAP into the AW. Embodiments of the invention are particularly useful for orally delivering drugs or other TAs which are degraded within the GI tract and require parenteral injection.

In various aspects, the present disclosure pertains to methods of treating or preventing bleeding at a tissue site comprising applying a chitosan powder composition to the tissue site. In various aspects, the present disclosure pertains to chitosan powder compositions for application to a tissue site, where the powder compositions comprise a chitosan salt, a crosslinked chitosan, a derivatized chitosan, or a combination thereof. In various aspects, the disclosure pertains to catheter assemblies, which are preloaded with a chitosan powder composition and which are configured to deliver the chitosan powder composition a tissue site.

Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

A delivery device may include a capsule housing, at least one tissue penetrating member in a sealed compartment in the capsule housing, wherein the at least one tissue penetrating member is configured to release a payload, and an actuator in the capsule housing and at least partially outside the sealed compartment, wherein the actuator is configured to advance the at least one tissue penetrating member out of the sealed compartment.

A drug delivery device having a central axis, the drug delivery device comprising: a first body part; a first attachment part attached to the first body part and having a first distal end; a second attachment part having a second distal end; and an actuator mechanism configured to move the first distal end towards the second distal end.

A double-balloon catheter device for gastrointestinal anastomosis. The double-balloon catheter device for gastrointestinal anastomosis includes a liquid injection assembly, a double-balloon assembly, and a supporting device (15) connecting the liquid injection assembly and the double-balloon assembly. The liquid injection assembly includes a first balloon liquid injection connection port (2), a guide wire connection port (3), and a second balloon liquid injection connection port (4). The double-balloon assembly includes a double-balloon catheter device (5), and includes a first balloon (6) and a second balloon (7) that can expand-and that are respectively disposed on the two ends of the double-balloon catheter device (5). The double-balloon catheter device (5) is provided with a first balloon liquid injection channel (51), a guide wire channel (52), and a second balloon liquid injection channel (53).

A catheter (1) has a distal side and a proximal side and includes a tip part (10) and a main body part (20) disposed proximal to the tip part (10), the main body part (20) includes a first layer (21) and a second layer (22), the first layer (21) contains 60% by mass or more of an ethylene-tetrafluoroethylene copolymer, the second layer (22) is disposed inside of the first layer (21) in a radial direction of the catheter (1) and contains 60% by mass or more of a polyamide resin, and a cantilever bending load of the tip part (10) is smaller than a cantilever bending load of the main body part (20).