The present invention provides an automatic drug delivery device. The automatic drug delivery device includes an enclosure and a first piston disposed in the enclosure. The first piston partitions the enclosure to a first drug delivery chamber and a first expansion chamber. A first through hole and a second through hole are formed in the wall of the enclosure, the first through-hole communicates with the first drug delivery chamber, and the second through-hole communicates with the first expansion chamber. A first targeted dissolution membrane covers the first through hole and the second through hole, and dissolves at a first targeted region. A drug is filled in the first drug delivery chamber, and an expandable material is included in the first expansion chamber. The expandable material in the first expansion chamber can expand after absorbing liquid.

a dilatable balloon catheter, comprising: a guide wire inserted and disposed in the inside of the catheter, an operation portion is fixedly connected to one end of the catheter, a balloon is disposed at the outer side of the catheter remote from the operation portion, the lumen of the catheter and the inner cavity of the balloon are connected by a communication structure provided on the catheter, the guide wire includes a first guide wire and a second guide wire which are separated from each other, the rear end of the first guide wire is connected to insertion-extraction structure in the rear end of the operation portion, the second guide wire is fixed to the inside of the catheter by a fixing process. The guide wire of the dilatable balloon catheter and the liquid injection lumen can share the same lumen, greatly reducing the diameter of the catheter in the present invention, so that the dilatable balloon catheter can be inserted into a narrow duct or lumen that needs to be expanded in human body through an device channel of an endoscope, and realize visualization operation.

A suction catheter holder is provided. The holder can include a housing that defines an interior open-space compartment for receiving at least a portion of a suction catheter. The housing can have an elongate structure defined by a longitudinal and lateral axis. The housing can include a base panel having a substantially flat exterior surface, and a plurality of sidewalls, each extending upward from the base to a roof panel having an interior surface that faces, at least in part, an interior surface of the base panel. The housing can include a front sidewall panel extending laterally along the front edges of the base and roof panels, between a pair of longitudinal sidewalls. The front sidewall panel can include an insertion through-hole for receiving the suction catheter and a securing through-hole for retaining the suction catheter in place.

A delivery device may comprise a sheath configured to be inserted into a body lumen of a patient. The sheath may have a proximal end, a distal end, a first channel extending within the sheath from the proximal end to the distal end, and a second channel extending within the sheath from the proximal end to the distal end. A collective cross-sectional area of the first channel and the second channel may be more than 50% of a total cross sectional area of the sheath. The device may also be comprised of a handle at the proximal end of the sheath, wherein the handle is configured to provide fluid communication between a first port and the first channel and a second port and the second channel.

A device includes an inflatable balloon, a reservoir disposed within the inflatable balloon, a needle compartment attached to the balloon and to the reservoir, an injection needle disposed within the needle compartment, and an inflation mechanism. The reservoir contains a therapeutic preparation. The inflation mechanism is structured to inflate the balloon, and upon inflation, the injection needle is structured to enter the reservoir. A method includes making an autoinjector available to a subject with instructions to ingest the autoinjector. The autoinjector is structured to inject a therapeutic preparation into a wall of a gastrointestinal tract of the subject responsive to ingestion of the autoinjector. The autoinjector includes an injection needle disposed in a needle compartment attached to a reservoir. The injection needle is initially separated from the reservoir, and is structured to enter the reservoir for delivery of the fluid therapeutic preparation through the needle into the wall.

The disclosure provides for a device and method for dilation. The dilation device may include a catheter body having a proximal portion and a distal portion, a dilation expandable body in fluid communication with a first opening on the distal portion of the catheter body, and an occlusion anchor expandable body in fluid communication with a second opening on the distal portion of the catheter body. The method for dilating a stricture site may include inserting the dilation device into a stricture site of a patient, expanding the occlusion anchor expandable body at the stricture site, and expanding the dilation expandable body at the stricture site.

The present disclosure provides with a device for temporary residence at an ileocecal valve of a subject, the device having a trapping configuration, wherein in the trapping configuration, the device is configured to be retained at the ileocecal valve of the subject when the device is positioned at the ileocecal valve; comprises a trapping assembly configured for blocking a cooperating ingestible object while allowing chyme flow, when the device is positioned at the ileocecal valve; and the device being further configured to transfer from the trapping configuration into an emptying configuration in which the device is configured to pass through the ileocecal valve. The present disclosure further provides with oral dosage forms cooperating with the device for local dispensing of a therapeutic agent at the ileocecal valve region.

The disclosure provides for a device and method for dilation. The dilation device may include a catheter body having a proximal portion and a distal portion, a dilation expandable body in fluid communication with a first opening on the distal portion of the catheter body, and an occlusion anchor expandable body in fluid communication with a second opening on the distal portion of the catheter body. The method for dilating a stricture site may include inserting the dilation device into a stricture site of a patient, expanding the occlusion anchor expandable body at the stricture site, and expanding the dilation expandable body at the stricture site.

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents (TA) within the GI tract and in particular to an antrum wall (AW). Particular embodiments provide a swallowable device (SD) such as a capsule for delivering drugs or other TA into the AW. The SD may contain a pressure sensitive component or assembly which triggers release and insertion of a therapeutic agent preparation (TAP) comprising at least one TA into the AW in response to external pressure, such as pressure applied to the swallowable capsule or other SD by antrum contractions. Particular embodiments of the SD may be shaped so that they self-align within an antrum to properly orient before injection of the TAP into the AW. Embodiments of the invention are particularly useful for orally delivering drugs or other TAs which are degraded within the GI tract and require parenteral injection.