This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a live biothcrapeutic.

A rigid hollow tubular adapter releasably attached at a longitudinal nozzle end to a flexible tube during equine nasogastric intubation comprising an annular sleeve having a stationary tubular member and a slidable tubular member. The slidable tubular member is delimited at its ends by the stationary tubular member and a detent member disposed between an equine reflux drainage hole and a longitudinal mouthpiece end. Operator's puffs of airflow through a mouthpiece urges the slidable member to slide toward the detent member closing the equine drainage hole to enable passage of medication into the equine stomach. Equine reflux urges the slidable tubular member to slide toward the stationary tubular member opening the reflux drainage hole to divert equine backflow downwardly through the equine backflow drainage hole preventing passage of equine reflux into the operator's mouth.

The present disclosure provides with a device (100) for temporary residence at an ileocecal valve of a subject, the device carrying a load of an active pharmaceutical ingredient (API) and having an expanded configuration. When the device is positioned at the ileocecal valve and in the expanded configuration, the device is configured to be retained at the ileocecal valve of the subject, and for releasing at least partially the active pharmaceutical ingredient while allowing chyme flow. The device is further configured to transfer from the expanded configuration into an emptying configuration in which the device is configured to pass through the ileocecal valve. This enables dispensing locally therapeutic substances at an ileocecal valve (ICV) region of a human body.

Disclosed are various embodiments for improved surgical devices and methods of using the same in connection with bariatric and gastroesophageal surgery. The present disclosure includes a lighted bougie device that can include an elongate member and a light source. The light source can be configured to emit near-infrared light. The light source can also be positioned about the bougie such that light emitted from the light source illuminates along a portion of the bougie.

An anesthetized catheter that includes the ability to administer substances and remove substances via the catheter orifice as well as pericatheter with the option of using wireless technology, while also having an indication system.

Various aspects of the present disclosure are directed toward medical devices, systems, and methods. The medical devices may include a portion having a radially expansive force greater than a radially expansive force other portions of the device. In addition, the medical device may include one or more constraining mechanisms for deployment of the medical devices.

An implantable device and methods for preparing and implanting said device into a subject for use in treating a medical condition when implanted therein is disclosed. The device comprises at least one coaxial fibre of a hydrophilic polymer and a hydrophobic polymer, wherein at least one of said polymers is loaded with an agent that is active towards treating the medical condition.

Origami robots, and associated systems, methods of treatment, and methods of manufacture are provided. A system includes an origami robot encapsulated for ingestion by a patient, such as in a biocompatible material that is dissolvable or meltable within the gastrointestinal tract. A method of treatment includes delivering an origami robot in a folded position into a gastrointestinal tract of a patient, causing the origami robot to unfold within the gastrointestinal tract, and directing the origami robot to a site requiring treatment in the gastrointestinal tract.

In various aspects, the present disclosure pertains to methods of treating or preventing bleeding at a tissue site comprising applying a chitosan powder composition to the tissue site, In various aspects, the present disclosure pertains to chitosan powder compositions for application to a tissue site, where the powder compositions comprise a chitosan salt, a crosslinked chitosan, a derivatized chitosan, or a combination thereof. In various aspects, the disclosure pertains to catheter assemblies, which are preloaded with a chitosan powder composition and which are configured to deliver the chitosan powder composition a tissue site.

Provided are a catheter device and a catheter package which are capable of preventing a bend from being formed in a catheter body.

The catheter body includes a wire state discrimination portion which discriminates a protruding state and a non-protruding state, in which the wire state discrimination portion includes a stopper which allows a transition from the protruding state to the non-protruding state, and blocks a transition from the non-protruding state to the protruding state.