A device for therapeutic neuromodulation in a nasal region can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

A system and method for inductive heating applications includes positioning one or more inductive heating elements in a location, delivering electromagnetic radiation, by a radiation source, to heat at least a portion of the one or more inductive heating elements, and detecting, by a detector, the heat generated by the one or more inductive heating elements. The system and method also include controlling, by a processing unit, a condition based on the detected heat.

Disclosed are methods of increasing blood circulation at a target site of a subject comprising exposing a target site of the subject to an alternating electric field for a period of time, the alternating electric field having a frequency and field strength, and exposing the target site of the subject to a vasodilator, wherein the vasodilator increases blood circulation at the target site of the subject. Disclosed are methods of maintaining or decreasing temperature at a target site of a subject comprising exposing a target site of the subject to an alternating electric field for a period of time, the alternating electric field having a frequency and field strength, and exposing the target site of the subject to a vasodilator, wherein the vasodilator increases circulation at the target site of the subject, wherein increased circulation maintains or decreases temperature at the target site.

Disclosed are methods of delivering a therapeutic to a target site of a subject comprising administering a lipid capsule to a target site of a subject, wherein the lipid capsule comprises a therapeutic agent; and applying an alternating electric field, at a frequency for a period of time, to the target site of the subject, wherein the alternating electric field releases the therapeutic from lipid capsule at the target site of the subject. Disclosed are methods of increasing target site specific release of a therapeutic agent in a subject comprising administering a lipid capsule to a target site of a subject, wherein the lipid capsule comprises a therapeutic agent; and applying an alternating electric field, at a frequency for a period of time, to the target site of the subject, wherein the alternating electric field releases the therapeutic agent from the lipid capsule at the target site of the subject, thereby increasing the target site specific release of the therapeutic agent. Disclosed are methods of treating comprise administering a lipid capsule to a target site of a subject in need thereof, wherein the lipid capsule comprises a therapeutic agent; and applying an alternating electric field, at a frequency for a period of time, to the target site of the subject in need thereof, wherein the alternating electric field releases the therapeutic agent from the lipid capsule at the target site of the subject in need thereof. Disclosed are methods of killing a cell comprising administering a lipid capsule to a target site, wherein the lipid capsule comprises a therapeutic agent; and applying an alternating electric field for a period of time, to the target site, wherein the alternating electric field releases the therapeutic agent from the lipid capsule at the target site, wherein the target site comprises a cell, wherein the therapeutic kills the cell.

Methods of treating cancer are provided. In some instances, the method comprises applying alternating electric fields to the abdomen of the subject at a frequency of 100 to 500 kHz, administering a checkpoint inhibitor to the subject, and administering systemic cancer therapy to the subject. In some instances, the cancer is pancreatic ductal adenocarcinoma.

The device comprises an outer conductor (7) and an inner conductor (9) arranged approximately coaxial with each other. The outer conductor surrounds the inner conductor. The outer conductor (7) and the inner conductor (9) are arranged and configured to generate an electromagnetic field with lines of force extending from a front surface (9A) of the inner conductor (9) to a front surface (7C) of the outer conductor (7). The device further comprises an energy delivery window (13) arranged in front of the outer conductor and the inner conductor.

A method for determining a change of temperature of an object. The method may include heating an object and measuring scattering parameters (S-parameters) of scattered microwave electric fields from the object. A distorted Born iterative method may be used to determine a change of a dielectric property of the object based on the measured S-parameters. A change of temperature of the object may be determined based on the change of the dielectric property of the object.

The device includes an outer conductor and an inner conductor arranged approximately coaxial with each other. The outer conductor surrounds the inner conductor. The outer conductor and the inner conductor are arranged and configured to generate an electromagnetic field with lines of force extending from a front surface of the inner conductor to a front surface of the outer conductor. The device further includes an energy delivery window arranged in front of the outer conductor and the inner conductor.

Methods, apparatuses, systems, and implementations for inductive heating of a foreign metallic implant are disclosed. A foreign metallic implant may be heated via AMF pulses to ensure that the surface of the foreign metallic implant heats in a uniform manner. As the surface temperature of the foreign metallic implant rises, acoustic signatures may be detected by acoustic sensors that may indicate that tissue may be heating to an undesirable level approaching a boiling point. Once these acoustic signatures are detected, the AMF pulses may be shut off for a time period to allow the surface temperature of the implant to cool before applying additional AMF pulses. In this manner, the surface temperature of a foreign metallic implant may be uniformly heated to a temperature adequate to treat bacterial biofilm buildup on the surface of the foreign metallic implant without damaging surrounding tissue. The AMF pulse treatment can be combined with an antibacterial/antimicrobial treatment regimen to reduce the time and/or antibacterial dosage amount needed to remove the biofilm from the metallic implant.

Provided is a device for microwave hyperthermia that may attach a flexible patch on the skin of a user based on a cross-section of a body tissue of the user, for example, a joint and muscle of a leg and an arm and may emit microwaves towards a plurality of points of the body tissue through the patch. The microwaves emitted toward the body tissue may have the same phase and maximum power. Accordingly, a maximum heat generation point may be generated in an area adjacent to the plurality of points. The device for microwave hyperthermia may move the maximum heat generation point by sequentially changing a phase and a direction of each of the microwaves. The device for microwave hyperthermia may uniformly distribute and maintain heat for treating pain and/or infection over the entire cross-section or a partial area. The device for microwave hyperthermia may be portable.