A tissue interface module has an applicator chamber on a proximal side of the tissue interface module and a tissue acquisition chamber on a distal side of the tissue interface module. The applicator chamber may include: an opening adapted to receive the applicator; an attachment mechanism positioned in the applicator chamber and adapted to attach the tissue interface module to the applicator; a sealing member positioned at a proximal side of the applicator chamber; and a vacuum interface positioned at a proximal side of the applicator chamber and adapted to receive a vacuum inlet positioned on a distal end of the applicator. The invention also includes corresponding methods.

A tissue interface module has an applicator chamber on a proximal side of the tissue interface module and a tissue acquisition chamber on a distal side of the tissue interface module. The applicator chamber may include: an opening adapted to receive the applicator; an attachment mechanism positioned in the applicator chamber and adapted to attach the tissue interface module to the applicator; a sealing member positioned at a proximal side of the applicator chamber; and a vacuum interface positioned at a proximal side of the applicator chamber and adapted to receive a vacuum inlet positioned on a distal end of the applicator. The invention also includes corresponding methods.

A process for heat treating biological tissue includes providing a plurality of energy emitters formed into an array. Treatment energy in the form of microwave energy is generated from the plurality of emitters and applied to target tissue. The treatment energy has energy and application parameters selected so as to raise the target tissue temperature sufficiently to create a therapeutic effect while maintaining an average temperature of the target tissue over several minutes at or below a predetermined temperature so as not to destroy or permanently damage the target tissue.

A process for heat treating biological tissue includes providing a plurality of energy emitters formed into an array. Treatment energy in the form of light beams is generated from the plurality of emitters and applied to target tissue. The treatment energy has energy and application parameters selected so as to raise the target tissue temperature sufficiently to create a therapeutic effect while maintaining an average temperature of the target tissue over several minutes at or below a predetermined temperature so as not to destroy or permanently damage the target tissue.

An energy delivery system includes an RF synthesizer circuit configured to generate an RF electric signal and a preamplification stage operably coupled to the RF synthesizer circuit. The preamplification stage has at least one attenuator. A board controller is operably coupled to the attenuator of the preamplification stage that is configured to modify a gain setting of the attenuator. An output connection is configured to provide a low-power signal or a high-power signal based on at least the RF electric signal and the gain setting. The low-power signal or high-power signal is provided to an RF applicator configured to couple an alternating RF electric field to animal tissue.

An energy delivery system includes an RF synthesizer circuit configured to generate an RF electric signal and a preamplification stage operably coupled to the RF synthesizer circuit. The preamplification stage has at least one attenuator. A board controller is operably coupled to the attenuator of the preamplification stage that is configured to modify a gain setting of the attenuator. An output connection is configured to provide a low-power signal or a high-power signal based on at least the RF electric signal and the gain setting. The low-power signal or high-power signal is provided to an RF applicator configured to couple an alternating RF electric field to animal tissue.

An electrosurgical waveform having both radiofrequency (RF) energy and microwave energy components that is arranged to perform efficient haemostasis in biological tissue. The waveform comprises a first portion primarily of RF electromagnetic energy, and a second portion primarily of microwave electromagnetic energy that follows the first portion. The second portion further comprises a plurality of RF pulses, wherein the first portion transitions to the second portion when either a duration of the first portion meets or exceeds a predetermined duration threshold, or an impedance determined during the first portion meets or exceeds a predetermined threshold. The waveform is arranged to deliver energy rapidly so that haemostasis can occur in a short time frame in a situation where the maximum available power is limited, or to avoid undesirable thermal damage to the biological tissue.

An electrosurgical waveform having both radiofrequency (RF) energy and microwave energy components that is arranged to perform efficient haemostasis in biological tissue. The waveform comprises a first portion primarily of RF electromagnetic energy, and a second portion primarily of microwave electromagnetic energy that follows the first portion. The second portion further comprises a plurality of RF pulses, wherein the first portion transitions to the second portion when either a duration of the first portion meets or exceeds a predetermined duration threshold, or an impedance determined during the first portion meets or exceeds a predetermined threshold. The waveform is arranged to deliver energy rapidly so that haemostasis can occur in a short time frame in a situation where the maximum available power is limited, or to avoid undesirable thermal damage to the biological tissue.

A process for heat treating biological tissue includes providing a plurality of energy emitters formed into an array. Treatment energy is generated from the plurality of emitters and applied to target tissue. The treatment energy has energy and application parameters selected so as to raise the target tissue temperature sufficiently to create a therapeutic effect while maintaining an average temperature of the target tissue over several minutes at or below a predetermined temperature so as not to destroy or permanently damage the target tissue.

An apparatus comprises a flexible substrate, a phased array antenna system disposed on the substrate, and a wearable applicator. The flexible substrate is configured to conform to a shape corresponding to a portion of a human body. The phased array antenna system comprises a plurality of antenna elements configured to resonate in response to an input signal and to generate a collective output electromagnetic pattern to propagate wirelessly to a target region in a human body. The wearable applicator is configured to align the collective output electromagnetic pattern with the target region.