A method and system for treating a subject with a disorder which provides within the subject at least one photoactivatable drug for treatment of the subject, applies initiation energy from at least one source to generate inside the subject a preferential x-ray flux for generation of Cherenkov radiation (CR) light capable of activating at least one photoactivatable drug, and from the CR light, activating inside the subject the at least one photoactivatable drug to thereby treat the disorder.

Methods and systems for treating a biological fluid with light are disclosed. The methods and systems include determining the light dose being delivered to a biological fluid and adjusting the duration of a treatment or the intensity of light emitted in the event of a detected light source outage.

The invention relates to an UV radiation device, comprising an LED comprising a nitridic material which is arranged to emit first UV radiation in a wavelength range of 200 nm-300 nm and a luminescent material doped with at least one of the following activators selected out of the group Eu.sup.2+, Ce.sup.3+, Pr.sup.3+, Nd.sup.3+, Gd.sup.3+, Tm.sup.3+, Sb.sup.3+, Tl.sup.+, Pb.sup.2+ and Bi.sup.3+, wherein the luminescent material is configured to convert at least a part of the primary UV radiation into secondary UV radiation, the primary UV radiation and the secondary UV radiation having a different spectral distribution.

The present disclosure relates to emissive polymeric matrices and methods of using them. The emissive polymeric matrices comprise a monomer such as, for example, 2-hydroxyehtyl methacrylate (HEMA) and at least one chromophore.

An ophthalmic stimulator for temporarily constricting a pupil of art eye comprises a mobile irradiation control system, to generate an irradiation control signal; an irradiation source, coupled to the irradiation control system, to generate an irradiation; and an irradiation delivery system, coupled to the mobile irradiation control system, to receive the irradiation from the irradiation source, and to deliver a patterned irradiation to an iris of the eye; wherein the mobile irradiation control system controls at least one of the irradiation source and the irradiation delivery system with the irradiation control signal so that the patterned irradiation causes a temporary constriction of the pupil of the eye, without causing a permanent constriction of the pupil.

A skin care device according to an embodiment of the present disclosure includes an outer case having a first opening, an inner case configured to be fastened to the outer case and having a second opening corresponding to the first opening, and a light output module configured to be accommodated between the outer case and the inner case, in which the light output module includes a module body configured to form a predetermined area based on a shape of the outer case or the inner case, a module cover formed along a part of an outer part of the module body, and, between the module body and the module cover, a plurality of light sources disposed in an array form along the outer part of the module body, and in which each of the plurality of light sources is disposed to face the module body.

A near-infrared (NIR) light therapy device having at least one NIR light source and a waveguide having i) a NIR light input surface and ii) a NIR light emitting surface. The waveguide includes a lens feature forming the NIR light input surface. The lens feature is configured to at least substantially collimate treatment NIR light from the at least one NIR light source and convey substantially collimated light in a first direction through the waveguide. The waveguide also includes a plurality of extractive surfaces on a surface of the waveguide that is configured to reflect the substantially collimated light through the light emitting surface to a subject. The plurality of extractive surfaces is also configured to create a substantially uniform NIR light output across the light emitting surface.

Systems, methods and computer-readable media are disclosed for providing therapeutic auditory stimulation. Consistent with disclosed embodiments, a system for providing therapeutic auditory stimulation may comprise a diagnostic unit that computes an EEG spectral density of a patient and a heart rate spectral density of a patient and provides values for one or more EEG frequency bands and one or more heart rate frequency bands. The system may also comprise a therapy unit that generates, based on the provided values, one or more stimulation waveforms corresponding to one or more of the EEG frequency bands and provides the stimulation waveforms for therapeutic auditory stimulation. The stimulation waveforms may comprise audible carrier frequencies modulated by signals with frequencies that vary exponentially with time. The EEG frequency bands may comprise the delta, theta, alpha, beta 1, beta 2, and gamma EEG frequency hands.

In certain embodiments, a neural probe comprises a substrate comprising elongated shanks for penetrating neural tissue, each comprising a proximal end and a distal end; at least one optical source integral to the neural probe for illuminating the neural tissue; and microelectrodes located proximate the distal end of the elongated shanks for monitoring neuronal activity. In certain embodiments, a method of monitoring neuronal activity comprises implanting the neural probe into a test subject such that the elongated shanks protrude into neural tissue of the test subject; illuminating the neural tissue with the at least one optical source; and measuring neuronal activity in response to illuminating the neural tissue. In certain embodiments, a device comprises a semiconductor chip; at least one optical source integral to the semiconductor chip; and sensor elements integral to the semiconductor chip for collecting data responsive to light emitted from the at least one optical source.

The present invention relates inter alia to a new class of heteroleptic metal complexes comprising condensed aromatic heterocyclic rings, their preparation and use.