Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer may include pre-programmed instructions and a computer interface, for interaction with a user of the system, for example, in order to track contained volumes of eluant and/or eluate, and/or to track time from completion of an elution performed by the system, and/or to calculate one or more system and/or injection parameters for quality control, and/or to perform purges of the system, and/or to facilitate diagnostic imaging.

Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo. Also disclosed are pharmaceutical compositions comprising a Cbl-b inhibitor and a cancer vaccine, as well as methods for treating cancer using a Cbl-b inhibitor and a cancer vaccine; and pharmaceutical compositions comprising a Cbl-b inhibitor and an oncolytic virus, as well as methods for treating cancer using a Cbl-b inhibitor and an oncolytic virus.

A guided robotic system is disclosed. The guided robotic system includes a magnetic resonance imaging apparatus for real-time imaging of a subject, a computer system for analyzing images in real-time, and a robotic system for guiding a robotic arm based on real-time analysis of the images. A method of using a guided robotic system is also disclosed. The method includes acquiring live magnetic resonance images of a subject, analyzing the live magnetic resonance images to continuously identify a target portion of the subject, guiding a robotic arm towards an identified target portion of the subject based on the live magnetic resonance images, and performing a procedure at the target portion of the subject. The non-limiting procedures using the guided robotic system may include, for example, biopsy, stent insertion.

A computer-based method of optimizing a radiotherapy treatment plan for a patient is proposed, wherein a complete treatment comprising both external beam therapy and brachytherapy is optimized in one procedure using an optimization problem comprising an objective function designed to optimize the total dose distribution as a combination of a first dose distribution to be provided by a first radiation set and a second dose distribution to be provided by a second radiation set. One of the radiation sets is external beam radiotherapy and the other is brachytherapy. The optimization is based on a total desired dose for the whole treatment, images of the patient before the treatment starts and an estimated image of the patient after the first radiation set has been delivered.

A computer-based method of optimizing a radiotherapy treatment plan for a patient is proposed, wherein a treatment plan to be provided by one radiation set is optimized taking into account a previously delivered dose delivered by a different radiation set. One of the radiation sets is external beam radiotherapy and the other is brachytherapy.

An electromagnetic field quality assurance system employing an electromagnetic field generator (10) for emitting an electromagnetic field (12), and one or more quality assurance electromagnetic sensors (11, 21, 31, 41, 50) for sensing the emission of the electromagnetic field (12). The system further employs a quality assurance controller (74) for assessing a tracking quality of the electromagnetic field (12) derived from a monitoring of a sensed position of each quality assurance electromagnetic sensor (11, 21, 31, 41, 50) within a field-of-view of the electromagnetic field (12). The electromagnetic field generator (10), an ultrasound probe (20), an ultrasound stepper (30) and/or a patient table (40) may be equipped with the quality assurance electromagnetic sensor(s) (11, 21, 31, 41, 50).

A system for selecting a calibration includes a data structure (138) including non-transitory computer readable storage media having a plurality of calibration entries stored therein and indexed to position and/or orientation criteria for a field generator. The field generator is configured for placement in an environment for sensor tracking. A calibration selection module (140) is configured to determine a position and/or orientation of the field generator and, based on the position and/or orientation, determine, using the data structure, corresponding calibration information stored in the data structure. The calibration information is optimized based upon the position and/or orientation of the field generator.

Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo. Also disclosed are pharmaceutical compositions comprising a Cbl-b inhibitor and a cancer vaccine, as well as methods for treating cancer using a Cbl-b inhibitor and a cancer vaccine; and pharmaceutical compositions comprising a Cbl-b inhibitor and an oncolytic virus, as well as methods for treating cancer using a Cbl-b inhibitor and an oncolytic virus.

An end effector for a surgical fastening device is provided. The end effector includes a body defining a longitudinal axis, one or more fasteners, an anvil, and a pusher. Each fastener has an unformed configuration and a formed configuration. Each fastener includes first and second arms that extend in opposite directions. The first arm has first and second elbow segments. The first elbow segment is configured to bend as the fastener is formed. The second elbow segment is configured to remain unbent as the fastener is formed. The pusher is configured to advance the fastener distally through the body and into engagement with the anvil to form the fastener against the anvil.

A device and method for radioembolization in the treatment of cancer cells in the body. In preferred embodiments, a radiomicrosphere is formed from a resin where an alpha emitting isotope is used for tumoricidal purposes. As the alpha emitter decays, daughters of the alpha decay are captured by the resin. In accordance with the preferred embodiments, the resin is polyfunctional where the resin has at least three different types of functional groups for cation binding. In preferred embodiments, the three functional groups bonded to the resin include a carboxylic acid group, a diphosphonic acid group, and a sulfonic acid group. In further embodiments, the device comprises at least two isotopes; wherein a first isotope is for therapeutic purposes and a second isotope is for dosimetric purposes. The second isotope is a positron emitter for PET based dosimetry. In preferred embodiments, a post-treatment radiation absorbed dose is determined using the present invention, allowing both treatment and treatment efficacy to be provided to a cancer patient.